Results 41 to 50 of about 516,407 (164)
Analysis of PERV-C superinfection resistance using HA-tagged viruses
Retrovirology, 2023 Background Using pigs as organ donors has advanced xenotransplantation to the point that it is almost ready for clinical use. However, there is still a zoonotic risk associated with xenotransplantation, and the potential transmission of porcine ...
Merle Flecks +4 more
doaj +1 more source
Viruses, 2019 Xenotransplantation using pig tissues and organs is under development in order to alleviate the increasing shortage of human transplants. Since xenotransplantation may be associated with the transmission of porcine microorganisms to the human recipient ...
Luise Krüger +6 more
doaj +1 more source
Infection Barriers to Successful Xenotransplantation Focusing on Porcine Endogenous Retroviruses [PDF]
, 2012 Xenotransplantation may be a solution to overcome the shortage of organs for the treatment of patients with organ failure, but it may be associated with the transmission of porcine microorganisms and the development of xenozoonoses.
Tönjes, Ralf R., Denner, Joachim
core +1 more source
Microchimerism, PERV and Xenotransplantation
Viruses, 2023 Microchimerism is the presence of cells in an individual that have originated from a genetically distinct individual. The most common form of microchimerism is fetomaternal microchimerism, i.e., cells from a fetus pass through the placenta and establish ...
Joachim Denner
doaj +1 more source
Virus Safety of Xenotransplantation
Viruses, 2022 The practice of xenotransplantation using pig islet cells or organs is under development to alleviate the shortage of human donor islet cells or organs for the treatment of diabetes or organ failure.
Joachim Denner
doaj +1 more source
Knockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs [PDF]
, 2008 Background: Xenotransplantation using porcine cells, tissues or organs may be associated with the transmission of porcine endogenous retroviruses (PERVs).
Dieckhoff, Britta +9 more
core +1 more source
Detection of non-reference porcine endogenous retrovirus loci in the Vietnamese native pig genome
Scientific Reports, 2022 The Vietnamese native pig (VnP)—a porcine breed with a small body—has proven suitable as a biomedical animal model. Here, we demonstrate that, compared to other breeds, VnPs have fewer copies of porcine endogenous retroviruses (PERVs), which pose a risk ...
Shinya Ishihara +7 more
doaj +1 more source
Genetically engineered pigs for xenotransplantation: Hopes and challenges
Frontiers in Cell and Developmental Biology, 2023 The shortage of donor resources has greatly limited the application of clinical xenotransplantation. As such, genetically engineered pigs are expected to be an ideal organ source for xenotransplantation.
Jiahui Xi +5 more
doaj +1 more source
Annals of Transplantation, 2012 Despite the fact that the risk of Porcine Endogenous Retroviruses (PERV) infection and propagation in human recipients is extremely low, such an event cannot be completely ruled out, especially in immunosuppressed patients. Therefore, the aim of this study was to analyze the expression of PERVs in vitro in the presence of immunosuppression agents ...
Daniel, Sypniewski +7 more
openaire +3 more sources
Cytotoxic Effects during Knock Out of Multiple Porcine Endogenous Retrovirus (PERV) Sequences in the Pig Genome by Zinc Finger Nucleases (ZFN). [PDF]
PLoS ONE, 2015 Xenotransplantation has been proposed as a solution to the shortage of suitable human donors for transplantation and pigs are currently favoured as donor animals.
Marwan Semaan +2 more
doaj +1 more source