Results 61 to 70 of about 516,407 (164)
Intervirology, 2005 <i>Objective:</i> Porcine endogenous retroviruses (PERVs) pose a risk for xenotransplantations using pig materials as they are present in the genome of all pigs and are able to infect human cells in vitro. Until recently, transmission of PERVs in vivo was only described in severe combined immunodeficient (SCID) and nude mice inoculated with
Markus, Irgang +7 more
openaire +2 more sources
Absence of IL-10 production by human PBMCs co-cultivated with human cells expressing or secreting retroviral immunosuppressive domains. [PDF]
PLoS ONE, 2018 Immunosuppression by retroviruses including the human immunodeficiency virus-1 (HIV-1) is well known, however the mechanisms how retroviruses induce this immunosuppression is not fully investigated.
Daniel Ivanusic +3 more
doaj +1 more source
Cell entry and exit of porcine endogenous retrovirus A: receptors and release inhibitor [PDF]
, 2010 Following the discovery that porcine endogenous retrovirus (PERV) can infect human cells, the potential risk of a zoonotic infection by PERV has been a major obstacle in the xenotransplantation field.
Mattiuzzo, G.
core
Characterizing and mapping porcine endogenous retroviruses in Westran pigs
, 2002 Since porcine endogenous retroviruses (PERVs) can infect cultured human cells, they are a potential hazard to xenotransplantation. For this reason, endogenous retroviruses from the Westran (Westmead Hospital transplantation) inbred line of pigs were ...
Lee, J. +7 more
core +1 more source
Characterising and Mapping Porcine Endogenous Retroviruses (PERVs) [PDF]
, 2001 The initial focus of this PhD project was on comparative gene mapping. Comparative gene mapping is facilitated by consensus PCR primers which amplify homologous gene fragments in many species.
Lee, Jun Heon
core
Xenotransplantation, Volume 33, Issue 5, September/October 2026.ABSTRACT Lung transplantation is the only long‐lasting life‐saving treatment for patients with end‐stage pulmonary disease, but the ever‐growing shortage of suitable donor organs leads to high mortality rates of the afflicted patients. Xenotransplantation, the transplantation of organs across species, has emerged as a promising alternative. This review
Nathalie Roters +6 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5476-5491, July 2026.ABSTRACT Background Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease marked by the destruction of pancreatic β‐cells, resulting in lifelong dependence on exogenous insulin. Despite advances in insulin delivery and glucose monitoring technologies, patients remain at risk for acute and long‐term complications, underscoring the need for ...
Tzu‐Min Lin +5 more
wiley +1 more source
Genome-wide inactivation of porcine endogenous retroviruses (PERVs)
, 2017 The shortage of organs for transplantation is a major barrier to the treatment of organ failure. While porcine organs are considered promising, their use has been checked by concerns about transmission of porcine endogenous retroviruses (PERVs) to humans.
Niu, D. +13 more
core +1 more source
Вавиловский журнал генетики и селекции, 2017 Modern transplantology is in need of transplants. To solve this problem, the use of animal organs and tissues for grafting to humans (xenografts) has been proposed. However, the progress in this direction is hampered by the risk of zoogenous infection of
R. B. Aitnazarov +5 more
doaj +1 more source
Ethical Considerations in Islet Xenotransplantation
Xenotransplantation, Volume 33, Issue 4, July/August 2026.ABSTRACT For the management of type 1 diabetes, islet xenotransplantation has emerged as a potential alternative to lifelong insulin therapy or islet allotransplantation. However, this progress raises significant ethical questions that warrant further exploration.
Daniel J. Hurst +6 more
wiley +1 more source