Results 61 to 70 of about 1,247 (177)

Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?

Retrovirology, 2018
Porcine endogenous retroviruses (PERVs) are present in the genome of all pigs, they infect certain human cells and therefore pose a special risk for xenotransplantation using pig cells, tissues and organs.
Joachim Denner
doaj   +1 more source

Key determinants of target DNA recognition by retroviral intasomes [PDF]

, 2015
BACKGROUND: Retroviral integration favors weakly conserved palindrome sequences at the sites of viral DNA joining and generates a short (4–6 bp) duplication of host DNA flanking the provirus.
Ballandras-Colas, A, Cherepanov, P, Engelman, AN, Maertens, GN, Serrao, E   +4 more
core   +2 more sources

Porcine Endogenous Retroviruses PERV-A and PERV-B Infect neither Mouse Cells in vitro nor SCID Mice in vivo

Intervirology, 2005
<i>Objective:</i> Porcine endogenous retroviruses (PERVs) pose a risk for xenotransplantations using pig materials as they are present in the genome of all pigs and are able to infect human cells in vitro. Until recently, transmission of PERVs in vivo was only described in severe combined immunodeficient (SCID) and nude mice inoculated with
Markus, Irgang, Alexander, Karlas, Christine, Laue, Volker, Specke, Stefan J, Tacke, Reinhard, Kurth, Jurgen, Schrezenmeir, Joachim, Denner   +7 more
openaire   +2 more sources

The Relationship between Embryonic Development and the Efficiency of Target Mutations in Porcine Endogenous Retroviruses (PERVs) Pol Genes in Porcine Embryos [PDF]

Animals, 2019
Porcine endogenous retrovirus (PERV) is a provirus found in the pig genome that may act as an infectious pathogen in humans who receive pig organ xenotransplantation. Inactivation of the PERV pol gene in porcine cells reportedly affects cell growth.
Hirata, Maki, Wittayarat, Manita, Hirano, Takayuki, Nguyen, Nhien Thi, Le, Quynh Anh, Namula, Zhao, Fahrudin, Mokhamad, Tanihara, Fuminori, Otoi, Takeshige   +8 more
openaire   +3 more sources

Potential for clinical pancreatic islet xenotransplantation [PDF]

, 2014
Diabetes mellitus is increasing worldwide. Type 1 diabetes can be treated successfully by islet allotransplantation, the results of which are steadily improving.
Bottino, R, Cooper, DKC, Hara, H, Nagaraju, S, Satyananda, V, Trucco, M, Wijkstrom, M   +6 more
core   +1 more source

Expression of porcine endogenous retroviruses (PERVs) in melanomas of Munich miniature swine (MMS) Troll

Veterinary Microbiology, 2007
Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pig breeds. Since some of them are able to infect human cells, they might represent a risk for xenotransplantation using pig cells or organs. However, the expression and biological role of PERVs in healthy pigs as well as in porcine tumours is largely unknown.
Angela Hafner-Marx, Britta Dieckhoff, Jenny Puhlmann, Joachim Denner, Kristina Büscher, Mathias Büttner, Nadja Herbach, Norbert Bannert, Reinhard Kurth, Rüdiger Wanke   +9 more
core   +4 more sources

An association between type A porcine endogenous retrovirus copy number and hematological parameters and gender in miniature pigs

Вавиловский журнал генетики и селекции, 2017
Pig is the most promising species for transplantation of organs and cells into humans, although implementation of xenotransplantation in clinical practice has been hindered by the risk of infecting the recipient with zoonotic infectious diseases. Porcine
R. B. Aitnazarov, S. V. Nikitin, G. V. Kontsevaya, M. I. Voevoda, N. S. Yudin   +4 more
doaj   +1 more source

Gene Therapy and Gene Editing in Type 1 Diabetes: CRISPR‐Based β‐Cell Replacement and Treg Immune Modulation Approaches

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease marked by the destruction of pancreatic β‐cells, resulting in lifelong dependence on exogenous insulin. Despite advances in insulin delivery and glucose monitoring technologies, patients remain at risk for acute and long‐term complications, underscoring the need for ...
Tzu‐Min Lin, Hui‐Fang Chang, Tzu‐Ching Lin, Cheng‐Han Lin, Yu‐Ling Sun, Chih‐Sheng Lin   +5 more
wiley   +1 more source

Computational Evaluation of the Strict Master and Random Template Models of Endogenous Retrovirus Evolution. [PDF]

PLoS ONE, 2016
Transposable elements (TEs) are DNA sequences that are able to replicate and move within and between host genomes. Their mechanism of replication is also shared with endogenous retroviruses (ERVs), which are also a type of TE that represent an ancient ...
Fabrícia F Nascimento, Allen G Rodrigo
doaj   +1 more source

The role of human SAMHD1 in restricting porcine endogenous retroviruses (PERVs) and the innate immune response to PERV infection in human primary immune cells [PDF]

, 2020
The release of porcine endogenous retrovirus (PERV) particles from pig cells is a potential risk factor during xenotransplantation by way of productively infecting the human transplant recipient.
Al-shehabi, Hussein Ali Nasser
core   +1 more source