Results 71 to 80 of about 1,247 (177)
Xenoperfusion—The Transformative Role of Machine Perfusion in Xenotransplantation
Xenotransplantation, Volume 33, Issue 3, May/June 2026.ABSTRACT Recent advances in xenotransplantation have gained substantial public and clinical attention as genetically modified porcine organs are now being transplanted into living human recipients. While only case reports have been published to date, the first clinical trials for kidney xenotransplantation are now ongoing.
Florian Huwyler +3 more
wiley +1 more source
Absence of IL-10 production by human PBMCs co-cultivated with human cells expressing or secreting retroviral immunosuppressive domains. [PDF]
PLoS ONE, 2018 Immunosuppression by retroviruses including the human immunodeficiency virus-1 (HIV-1) is well known, however the mechanisms how retroviruses induce this immunosuppression is not fully investigated.
Daniel Ivanusic +3 more
doaj +1 more source
Characterisation of a human cell-adapted porcine endogenous retrovirus PERV-A/C. [PDF]
, 2010 Background: Porcine endogenous retroviruses (PERVs) pose a potential risk for xenotransplantation using pig cells, tissues or organs. A special threat comes from viruses generated by recombination between human-tropic PERV-A and ecotropic PERV-C ...
Denner, Joachim +6 more
core +1 more source
Presence of Porcine Endogenous Retrovirus C in Domestic Pigs [PDF]
, 2023 The goal of this study is to create new mutations in the Asymmetric Leaves1 (AS1) gene of Arabidopsis using CRISPR vectors to induce mutations. The intention is to analyze these mutations in order to better understand the structure and function of the ...
Welton, Avery
core +2 more sources
Retroviral Insertion Polymorphism (RIP) of Porcine Endogenous Retroviruses (PERVs) in Pig Genomes
AnimalsEndogenous retroviruses (ERVs) are one of the superfamilies of long terminal repeat retrotransposons (LTRs) in mice and humans. Approximately 8% of the pig genome is composed of sequences derived from LTRs. While the majority of ERVs in pigs have decayed, a small number of full-length copies can still mobilize within the genome. This study investigated
Zhanyu Du +4 more
openaire +3 more sources
Vaccination against the Koala Retrovirus (KoRV): Problems and Strategies [PDF]
, 2021 The koala retrovirus (KoRV) is spreading in the koala population from the north to the south of Australia and is also in the process of endogenization into the koala genome.
Denner, Joachim
core +1 more source
Xenotransplantation Literature Update: July–December 2025
Xenotransplantation, Volume 33, Issue 2, March/April 2026.ABSTRACT The second half of 2025 marked a significant transition for xenotransplantation, shifting further from experimental feasibility to early clinical translation. Prolonged physiologic support from genetically engineered porcine kidneys and livers in human recipients provided unprecedented insight into organ compatibility, rejection dynamics, and ...
Kasra Shirini +3 more
wiley +1 more source
Xenotransplantation: Reduction of the risk of transmission of porcine endogenous retroviruses (PERV) [PDF]
, 2014 Die Xenotransplantation mit porzinen Zellen, Gewebe oder Organe könnte die immer größer werdende Lücke zwischen Nachfrage und Angebot der menschlichen Spenderorgane reduzieren. Dies kann jedoch durch die Anwesenheit von porzinen endogenen Retroviren (PERVs) erschwert werden.
openaire +2 more sources
Вавиловский журнал генетики и селекции, 2017 Modern transplantology is in need of transplants. To solve this problem, the use of animal organs and tissues for grafting to humans (xenografts) has been proposed. However, the progress in this direction is hampered by the risk of zoogenous infection of
R. B. Aitnazarov +5 more
doaj +1 more source
Organ Transplantation: Current Status, Challenges, and Future Prospects
MedComm, Volume 7, Issue 1, January 2026.Organ transplantation success relies on precise modulation of the alloimmune response across distinct temporal phases of rejection. Hyperacute rejection results from preformed antibodies activating complement and causing thrombosis, while acute rejection involves T cell‐ and antibody‐mediated mechanisms that drive endothelial activation and ...
Xinqiang Li, Ruidong Ding, Jinzhen Cai
wiley +1 more source