Results 71 to 80 of about 516,407 (164)

Screening for Viruses in Indigenous Greek Black Pigs

Microorganisms
The successful advancement of xenotransplantation has led to the development of highly sensitive detection systems for the screening of potentially zoonotic viruses in donor pigs and preventing their transmission to the recipient.
Hina Jhelum, Vasileios Papatsiros, Georgios Papakonstantinou, Ludwig Krabben, Benedikt Kaufer, Joachim Denner   +5 more
doaj   +1 more source

An effective vaginal gel to deliver CRISPR/Cas9 system encapsulated in poly (β-amino ester) nanoparticles for vaginal gene therapy

EBioMedicine, 2020
Background: Gene therapy has held promises for treating specific genetic diseases. However, the key to clinical application depends on effective gene delivery.
Gang Niu, Zhuang Jin, Chong Zhang, Dan He, Xueqin Gao, Chenming Zou, Wei Zhang, Jiahui Ding, Bhudev C. Das, Konstantin Severinov, Inga Isabel Hitzeroth, Priya Ranjan Debata, Xin Ma, Xun Tian, Qinglei Gao, Jun Wu, Zeshan You, Rui Tian, Zifeng Cui, Weiwen Fan, Weiling Xie, Zhaoyue Huang, Chen Cao, Wei Xu, Hongxian Xie, Hongyan Xu, Xiongzhi Tang, Yan Wang, Zhiying Yu, Hui Han, Songwei Tan, Shuqin Chen, Zheng Hu   +32 more
doaj   +1 more source

Xenotransplantation Literature Update: January–June 2026

Xenotransplantation, Volume 33, Issue 4, July/August 2026.
ABSTRACT In the first half of 2026, xenotransplantation advanced through refinement rather than dramatic new clinical milestones. Clinical studies described graft physiology, immune infiltration, complement activation, coagulation incompatibility, and early function in living recipients, decedent models, and clinical islet xenotransplantation ...
Kasra Shirini, Joseph M. Ladowski, Niket Harsh, Raphael P. H. Meier   +3 more
wiley   +1 more source

Distribution Of Porcine Endogenous Retrovirus (PERV) Variants In Domestic And Feral Pigs [PDF]

, 2018
Xenotransplantation is considered an alternative to allotransplantation to relieve the current shortage of human organs. Due to their similar size and physiology, the organs of pigs are of particular interest for this purpose. Endogenous retroviruses are
Acharya, Rashmi
core   +1 more source

Retroviral Insertion Polymorphism (RIP) of Porcine Endogenous Retroviruses (PERVs) in Pig Genomes

Animals
Endogenous retroviruses (ERVs) are one of the superfamilies of long terminal repeat retrotransposons (LTRs) in mice and humans. Approximately 8% of the pig genome is composed of sequences derived from LTRs. While the majority of ERVs in pigs have decayed, a small number of full-length copies can still mobilize within the genome. This study investigated
Zhanyu Du, Cai Chen, Yao Zheng, Xiaoyan Wang, Chengyi Song   +4 more
openaire   +3 more sources

Bioartificial Livers Developed From Gene‐Edited Pig Hepatocyte Organoids Improve Amino Acid and Lipid Profiles in the Plasma of Patients With Liver Failure

MedComm, Volume 7, Issue 6, June 2026.
A bioartificial liver (BAL) integrating GGTA1‐knockout porcine hepatocytes and R‐spondin1‐overexpressing endothelial organoids was tested using plasma from patients with acute‐on‐chronic liver failure (ACLF). The BAL system actively modulates amino acid and lipid metabolism, enhances detoxification, partially restores overall metabolic balance, and ...
Yuting He, Yang Deng, Xinglong Zhu, Mengyu Gao, Qin Liu, Wanliu Peng, Yanyan Zhou, Lang Bai, Ji Bao   +8 more
wiley   +1 more source

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, Volume 3, Issue 2, Page 87-101, June 2026.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

Concise classification of the genomic porcine endogenous retroviral γ1 load to defined lineages [PDF]

, 2008
We investigated the infection history of porcine endogenous retroviruses (PERV) γ1 by analyzing published env and LTR sequences. PERV sequences from various breeds, porcine cell lines and infected human primary cells were included in the study.
Klymiuk, Nikolai, Wolf, Eckhard, Aigner, Bernhard   +2 more
core   +1 more source

An Evolutionarily Young Polar Bear (Ursus maritimus) Endogenous Retrovirus Identified from Next Generation Sequence Data

Viruses, 2015
Transcriptome analysis of polar bear (Ursus maritimus) tissues identified sequences with similarity to Porcine Endogenous Retroviruses (PERV). Based on these sequences, four proviral copies and 15 solo long terminal repeats (LTRs) of a newly described ...
Kyriakos Tsangaras, Jens Mayer, David E. Alquezar-Planas, Alex D. Greenwood   +3 more
doaj   +1 more source

Early Experimental Report of the First 8‐Gene‐Edited Pig‐to‐Rhesus Macaque Cardiac Xenotransplantation in China

Xenotransplantation, Volume 33, Issue 3, May/June 2026.
ABSTRACT Objectives This study aimed to investigate the functional recovery of an 8‐gene‐edited pig heart after orthotopic xenotransplantation, the characteristics of the recipient's immune responses, and the efficacy of postoperative complication management to provide comprehensive experimental evidence for the clinical translation of xenogeneic ...
Xianzhi Wang, Xijie Wu, Ziqiang Dai, Licheng Yan, Jie Yan, Dongsheng He, Shangxuan Li, Zhipeng Ren, Gen Zhang, Guanzheng Cui, Xin Li, Xianhua Li, Yulong Guan, Guangyu Pan, Ik Jin Yun, Wensheng Zhou, Dengke Pan, Dianyuan Li   +17 more
wiley   +1 more source