Results 91 to 100 of about 1,247 (177)

Considering the Risks and Costs of Solid Organ Xenotransplantation

Advanced Biology, Volume 9, Issue 4, April 2025.
This perspective discusses the rationale, risks, and costs of whole‐organ xenotransplantation. It considers alternative strategies to obviate the demand for transplants and optimize allotransplantation systems and practices that do not impose xenotransplantation's harms and risks, and whether they are the most ethical and effective means to increase ...
Catharine E. Krebs, Janine McCarthy, Kristie Sullivan, James Craner, Brendan Parent, Ann Lam   +5 more
wiley   +1 more source

Recreating the Endocrine Niche: Advances in Bioengineering the Pancreas

Artificial Organs, Volume 49, Issue 4, Page 541-555, April 2025.
During the isolation process, islets are disconnected from their extracellular matrix and vasculature, leading to significant islet loss and poor graft function. This review covers various strategies developed to produce the building blocks for generating a vascularized, immune‐protected insulin‐secreting construct, emphasizing the importance of the ...
Laura Mar Fonseca, Nicerine Krause, Fanny Lebreton, Ekaterine Berishvili   +3 more
wiley   +1 more source

Immunometabolism of Liver Xenotransplantation and Prospective Solutions

Advanced Science, Volume 12, Issue 9, March 6, 2025.
After xenotransplantation, pig livers will replace those of human patients to maintain the stability of metabolism and immune system. The incompatibility of immunometabolism between humans and pigs induces rejection, inflammation, coagulation dysfunction, and liver failure. The profile of immunometabolism pre‐transplantation and post‐transplantation is
Shoulong Deng, Yi Zhang, Shasha Shen, Chongyang Li, Chuan Qin   +4 more
wiley   +1 more source

International Xenotransplantation Association (IXA) Position Paper on the History, Current Status, and Regulation of Xenotransplantation

Xenotransplantation, Volume 32, Issue 2, March/April 2025.
ABSTRACT Recent landmark clinical translation of xenotransplantation depended upon multiple innovations by the xenotransplant community, including the introduction of a variety of source pig genetic modifications, technical innovations, and novel immunosuppressive strategies, as well as the development of ethical and regulatory frameworks to support ...
Wayne J. Hawthorne, Richard N. Pierson III, Leo Buhler, Peter J. Cowan, Jay Fishman, Rita Bottino, Raphael P. H. Meier, Paolo Brenner, Eckhard Wolf, Emanuele Cozzi, Muhammad M. Mohiuddin   +10 more
wiley   +1 more source

Insertional Variations of Two Porcine Endogenous Retroviruses (PERVs) in Korean Native Pigs and Asian Wild Boars

Asian-Australasian Journal of Animal Sciences, 2007
Porcine Endogenous Retroviruses (PERVs) are a major concern in relation to xenotransplantation. Previous research indicated that PERVs are present at about 50 copies in the pig genome and their chromosomal insertion sites are different among pig breeds.
Jung, K.C., Yu, S.L., Kim, Thi Chantha, Jeon, J.T., Rogel Gaillard, Claire, Park, C.S., Jin, D.I., Moran, Christopher, Lee, J.H.   +8 more
openaire   +2 more sources

The Relationship between Embryonic Development and the Efficiency of Target Mutations in Porcine Endogenous Retroviruses (PERVs) Pol Genes in Porcine Embryos [PDF]

, 2020
Porcine endogenous retrovirus (PERV) is a provirus found in the pig genome that may act as an infectious pathogen in humans who receive pig organ xenotransplantation.
Fahrudin, Mokhamad, Hirano, Takayuki, Hirata, Maki, Le, Quynh Anh, Namula, Zhao, Nguyen, Nhien Thi, Otoi, Takeshige, Tanihara, Fuminori, Wittayarat, Manita   +8 more
core  

Additional file 1 of Rare isolation of human-tropic recombinant porcine endogenous retroviruses PERV-A/C from Göttingen minipigs

, 2022
Additional file 1. Figure S1: Sequence of a part of the envelope protein of the PERV isolated from GöMP number 8 in comparison with sequences of a PERV-A (Accession-Number AJ293656.1), a PERV-C (Accession-Number KY352351), and PERV-F [11].
Halecker, Sabrina, Krabben, Ludwig, Kristiansen, Yannick, Krüger, Luise, Möller, Lars, Becher, Dietmar, Laue, Michael, Kaufer, Benedikt, Reimer, Christian, Denner, Joachim   +9 more
openaire   +1 more source

Type W Human Endogenous Retrovirus (HERV-W) Integrations and Their Mobilization by L1 Machinery: Contribution to the Human Transcriptome and Impact on the Host Physiopathology [PDF]

, 2017
Human Endogenous Retroviruses (HERVs) are ancient infection relics constituting ~8% of our DNA. While HERVs' genomic characterization is still ongoing, impressive amounts of data have been obtained regarding their general expression across tissues. Among
Grandi, Nicole, Tramontano, Enzo
core   +1 more source

Preliminary PCR-based screening indicates a higher incidence of Porcine Endogenous Retrovirus subtype C (PERV-C) in feral versus domestic swine [PDF]

, 2019
Xenotransplantation is considered a potential alternative to allotransplantation to relieve the current shortage of human organs. Due to their similar size and physiology, the organs of pigs are of particular interest for this purpose.
Acharya, Rashmi, Gillock, Eric T., Keener, Robert, Wallis, Zoey K.   +3 more
core   +1 more source

Virological aspects of non-human primates or swine-to human xenotransplantation [PDF]

, 2018
There are a number of human diseases, which can lead to organ failure. The consequence is often the need for a transplant. The number of performed operations is very low due to the shortage of organs for transplantation.
Hryhorowicz, Magdalena, Lipiński, Daniel, Mazurkiewicz, Natalia, Nowak, Agnieszka, Słomski, Ryszard, Zeyland, Joanna   +5 more
core   +2 more sources