Results 91 to 100 of about 516,407 (164)

Role of DNA methylation in expression and transmission of porcine endogenous retroviruses

, 2013
Porcine endogenous retroviruses (PERV) represent a major safety concern in pig-to-human xenotransplantation. To date, no PERV infection of a xenograft recipient has been recorded; however, PERVs are transmissible to human cells in vitro.
Scobie, Linda, Mattiuzzo, Giada, Hector, Ralph D., Takeuchi, Yasuhiro, Vesely, Pavel, Hejnar, Jirˇí, Matouskova, Magda, Daniel, Petr, Scobie, Linda; id_orcid   +8 more
core   +1 more source

Lack of antibody response in pigs immunized with the transmembrane envelope protein of porcine endogenous retroviruses

, 2014
Recently we immunised different mammalian species (goats, mice, rats, rabbits, guinea pigs, hamsters) with the recombinant ectodomain of the transmembrane envelope (TM) protein p15E of the porcine endogenous retrovirus (PERV).
Keller, Martina, Petersen, Björn, Niemann, Heiner, Denner, Joachim   +3 more
core   +1 more source

Characterization of germline porcine endogenous retroviruses from Large White pig

, 2004
Porcine endogenous retroviruses (PERV) are of concern when the microbiological safety aspects of xenotransplantation are considered. Four unique isolates of PERV B have been identified previously from a lambda library constructed from genomic DNA from a ...
Logan, NA, Logan, Nicola A., Onions, David, Taylor, S, Patience, C, Quinn, G, Scobie, Linda; id_orcid, Scobie, L, Meikle, Sharon, Taylor, Samantha, Patience, Clive, Onions, D, Meikle, S, Quinn, Gary   +13 more
core   +1 more source

Restriction of Porcine Endogenous Retrovirus by Porcine APOBEC3 Cytidine Deaminases

, 2011
Xenotransplantation of porcine cells, tissues, and organs shows promise to surmount the shortage of human donor materials. Among the barriers to pig-to-human xenotransplantation are porcine endogenous retroviruses (PERV) since functional representatives ...
Nicole Fischer, Heidi Kuiper, Andreas Spötter, Eva Dörrschuck, Ronny Möller, Ralf R. Tönjes, Ignacio G. Bravo, Carsten Münk, Kay-Martin Hanschmann, Klaus Cichutek   +9 more
core   +1 more source

Insertional Variations of Two Porcine Endogenous Retroviruses (PERVs) in Korean Native Pigs and Asian Wild Boars

Asian-Australasian Journal of Animal Sciences, 2007
Porcine Endogenous Retroviruses (PERVs) are a major concern in relation to xenotransplantation. Previous research indicated that PERVs are present at about 50 copies in the pig genome and their chromosomal insertion sites are different among pig breeds.
Jung, K.C., Yu, S.L., Kim, Thi Chantha, Jeon, J.T., Rogel Gaillard, Claire, Park, C.S., Jin, D.I., Moran, Christopher, Lee, J.H.   +8 more
openaire   +2 more sources

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

The role of human SAMHD1 in restricting porcine endogenous retroviruses (PERVs) and the innate immune response to PERV infection in human primary immune cells

, 2020
Die Freisetzung von Porcinen Endogenen Retroviren (PERVs) aus Schweinezellen ist ein potenzieller Risikofaktor während der Xenotransplantation. PERV ist in der Lage, in humanen Zelllinien zu replizieren. Mögliche Abwehrmechanismen gegen die PERV-Replikation sind zelluläre Restriktionsfaktoren.
openaire   +3 more sources

The significance of porcine replication defect endogenous retroviruses in xenotransplantation

, 2014
The shortage of human tissues and organs for allotransplantation can be overcome by xenotransplantation. As a source of organs, the miniature pig is convenient.
Daniel, Petr
core  

Investigation of interactions between porcine endogenous retroviruses (PERV) and susceptible host cells

Die Xenotransplantation (XTx) vom Schwein auf den Menschen hat das Potenzial, den Mangel an menschlichen Allotransplantaten zu beheben. Trotz der erheblichen Fortschritte der letzten Jahre kann das zoonotische Risiko durch die potenzielle Übertragung porziner endogener Retroviren (PERVs) nicht ausgeschlossen werden. Im Gegensatz zu den meisten porzinen
openaire   +2 more sources

No transmission of porcine endogenous retroviruses (PERVs) in a long-term pig to rat xenotransplantation model and no infection of immunosuppressed rats.

Annals of transplantation, 2008
Xenotransplantation from pig to humans may be associated with the risk of transmission of porcine endogenous retroviruses (PERVs) that are present in the genome of all pigs and that infect human cells in vitro. However, it remains unclear whether PERVs infect transplant recipients in vivo and, if so, whether they are pathogenic.
Joachim, Denner, Volker, Specke, Alexander, Karlas, Irina, Chodnevskaja, Thomas, Meyer, Vasiliy, Moskalenko, Reinhard, Kurth, Karin, Ulrichs   +7 more
openaire   +1 more source