Results 81 to 90 of about 516,407 (164)
The Japanese Macaque as a Diabetes Recipient Animal Model for Porcine Islet Xenotransplantation
MedComm, Volume 7, Issue 4, April 2026.Porcine islet xenotransplantation is effective for severe diabetes; however, preclinical studies are essential. In this study, we evaluated the suitability of the Japanese macaque as a recipient model for islet xenotransplantation, including identifying the preferred method to induce diabetes.
Naoaki Sakata +4 more
wiley +1 more source
Porcine Endogenous Retroviruses Inhibit Human Immune Cell Function: Risk for Xenotransplantation? [PDF]
, 2000 Transgenic pigs are currently the most favored potential source of organs for xenotransplantation. Like all mammalian species they all harbor endogenous retroviruses in their genome. These porcine endogenous retroviruses (PERVs) are produced from several
Tacke, Stefan J. +2 more
core +1 more source
Inhibition of porcine endogenous retroviruses by RNA interference: increasing the safety of xenotransplantation [PDF]
, 2004 Transplantation of porcine xenografts into human recipients is a realistic option to overcome the growing worldwide shortage of suitable allogeneic organs.
Karlas, Alexander +2 more
core +1 more source
Xenotransplantation Literature Update: July–December 2025
Xenotransplantation, Volume 33, Issue 2, March/April 2026.ABSTRACT The second half of 2025 marked a significant transition for xenotransplantation, shifting further from experimental feasibility to early clinical translation. Prolonged physiologic support from genetically engineered porcine kidneys and livers in human recipients provided unprecedented insight into organ compatibility, rejection dynamics, and ...
Kasra Shirini +3 more
wiley +1 more source
The detection and role of human endogenous retroviruses in multiple sclerosis and other neurological diseases [PDF]
, 2009 A thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Master of PhilosophyHuman endogenous retroviruses (HERVs) are estimated to form approximately 5% of the human genome.
Smith, Richard G.
core +3 more sources
Organ Transplantation: Current Status, Challenges, and Future Prospects
MedComm, Volume 7, Issue 1, January 2026.Organ transplantation success relies on precise modulation of the alloimmune response across distinct temporal phases of rejection. Hyperacute rejection results from preformed antibodies activating complement and causing thrombosis, while acute rejection involves T cell‐ and antibody‐mediated mechanisms that drive endothelial activation and ...
Xinqiang Li, Ruidong Ding, Jinzhen Cai
wiley +1 more source
, 2022 Additional file 1. Figure S1: Sequence of a part of the envelope protein of the PERV isolated from GöMP number 8 in comparison with sequences of a PERV-A (Accession-Number AJ293656.1), a PERV-C (Accession-Number KY352351), and PERV-F [11].
Halecker, Sabrina +9 more
openaire +1 more source
, 2001 Different classes of porcine endogenous retroviruses (PERVs), which have the potential to infect humans during xenotransplantation, have been isolated from the pig genome.
Mang, R. +4 more
core +1 more source
, 2007 0\. Titelblatt und Inhaltsverzeichnis 1\. Einleitung 1 2\. Material 20 3\. Methoden 27 4\. Ergebnisse 53 5\. Diskussion 98 6\. Zusammenfassung 125 7\. Literaturverzeichnis I 8\.
Dieckhoff, Britta Alexandra
core +1 more source
Distribution of porcine endogenous retroviruses (PERVs) DNA in organs of a domestic pig.
Annals of transplantation, 2005 Domestic pig may serve as the most appropriate organ source for human xenotransplantation in the future. However, there is a serious threat of xenogeneic pathogens transmission, especially porcine endogenous retroviruses (PERVs) which are present in genomes of all pigs. The aim of this study was to monitor the prevalence and distribution of PERV DNA in
Daniel, Sypniewski +6 more
openaire +1 more source