Detection of non-reference porcine endogenous retrovirus loci in the Vietnamese native pig genome
Scientific Reports, 2022 The Vietnamese native pig (VnP)—a porcine breed with a small body—has proven suitable as a biomedical animal model. Here, we demonstrate that, compared to other breeds, VnPs have fewer copies of porcine endogenous retroviruses (PERVs), which pose a risk ...
Shinya Ishihara +7 more
doaj +1 more source
Genetically engineered pigs for xenotransplantation: Hopes and challenges
Frontiers in Cell and Developmental Biology, 2023 The shortage of donor resources has greatly limited the application of clinical xenotransplantation. As such, genetically engineered pigs are expected to be an ideal organ source for xenotransplantation.
Jiahui Xi +5 more
doaj +1 more source
Safety of Xenotransplantation: Development of screening methods and testing for porcine viruses [PDF]
, 2018 Xenotransplantation using pig cells, tissues or organs might be a promising solution to overcome the shortage for organs suitable for allotransplantation. Because of several reasons, the pig is currently the favoured donor species.
Janich geb. Plotzki, Elena
core +1 more source
Porcine Endogenous Retrovirus Induces CXCL10 in Human Monocytes and Monocyte-Derived Primary Cells
Intervirology, 2022 Introduction: Pigs are suitable donor species for xenotransplantation and biological materials from these animals are used for this purpose for many years.
Hussein Al-Shehabi, Norbert Bannert
doaj +1 more source
Xenotransplantation: past, present, and future [PDF]
, 2017 PURPOSE OF REVIEW: To review the progress in the field of xenotransplantation with special attention to most recent encouraging findings which will eventually bring xenotransplantation to the clinic in the near future.
Cooper, David K.C. +2 more
core +1 more source
The role of genetically engineered pigs in xenotransplantation research [PDF]
, 2015 There is a critical shortage in the number of deceased human organs that become available for the purposes of clinical transplantation. This problem might be resolved by the transplantation of organs from pigs genetically engineered to protect them from ...
Ayares, David +4 more
core +1 more source
Possible Transmission of Zoonoses in Xenotransplantation: Porcine Endogenous Retroviruses (PERVs) from an Immunological Point of View [PDF]
Acta Veterinaria Scandinavica, 2004 Possible transmission of zoonoses in xenotransplantation : porcine endogenous retroviruses (PERVs) from an immunological point of ...
Blomberg Jonas +4 more
openaire +3 more sources
European Journal of Medical Research, 2012 Background Our institute has developed a novel bio-artificial liver (BAL) support system, based on a multi-layer radial-flow bioreactor carrying porcine hepatocytes and mesenchymal stem cells.
Han Bing +9 more
doaj +1 more source
The Japanese Macaque as a Diabetes Recipient Animal Model for Porcine Islet Xenotransplantation [PDF]
MedComm (2020)Porcine islet xenotransplantation is effective for severe diabetes; however, preclinical studies are essential. In this study, we evaluated the suitability of the Japanese macaque as a recipient model for islet xenotransplantation, including identifying the preferred method to induce diabetes.
Sakata N +4 more
europepmc +2 more sources
An approach to the control of disease transmission in pig-to-human xenotransplantation. [PDF]
, 2000 : Although several major immunologic hurdles need to be overcome, the pig is currently considered the most likely source animal of cells, tissues and organs for transplantation into humans.
A. D. M. E. Osterhaus +57 more
core +4 more sources