Results 51 to 60 of about 3,386 (182)

Characterization of germline porcine endogenous retroviruses from Large White pig

Journal of General Virology, 2004
Porcine endogenous retroviruses (PERV) are of concern when the microbiological safety aspects of xenotransplantation are considered. Four unique isolates of PERV B have been identified previously from a lambda library constructed from genomic DNA from a Large White pig.
Scobie, Linda, Taylor, Samantha, Logan, Nicola A., Meikle, Sharon, Onions, David, Patience, Clive, Quinn, Gary   +6 more
openaire   +3 more sources

Co-Cultivation Assays for Detecting Infectious Human-Tropic Porcine Endogenous Retroviruses (PERVs). [PDF]

Int J Mol Sci
Porcine endogenous retroviruses (PERVs) are integrated into the genome of all pigs. As they can be released as infectious virus particles capable of infecting human cells in vitro, they pose a potential risk for xenotransplantation involving pig cells or
Denner J.
europepmc   +2 more sources

Virus safety of xenotransplantation and porcine endogenous retroviruses (PERVs) [PDF]

, 2014
Introduction: The shortage of organs for patients is an issue that needs addressing. Xenotransplantation using pig cells or organs is the most favored option. However, pigs contain porcine endogenous retroviruses (PERV) in their genome which infect human cells. Like all retroviruses PERVs have immunosuppressive properties and may induce tumors.
Anders, Maximilian
openaire   +4 more sources

Porcine endogenous retroviruses get the chop [PDF]

Nature Reviews Genetics, 2015
Denise Waldron
openaire   +2 more sources

Elimination of porcine endogenous retroviruses from pig cells [PDF]

Xenotransplantation, 2015
J. Denner
openaire   +3 more sources

Structure of the Core Postfusion Porcine Endogenous Retrovirus Fusion Protein

mBio, 2022
Retroviral elements from endogenous retroviruses have functions in mammalian physiology. The best-known examples are the envelope proteins that function in placenta development and immune suppression.
Trevor T. Dean, Vitor Hugo B. Serrão, Jeffrey E. Lee   +2 more
doaj   +1 more source

Efficient and Safe Editing of Porcine Endogenous Retrovirus Genomes by Multiple-Site Base-Editing Editor

Cells, 2022
Gene-modified miniature pigs serve as alternative tissue and organ donors for xenotransplantation to alleviate the shortage of human allogenic organs.
Shuwen Zheng, Haiwen Zhong, Xiaoqing Zhou, Min Chen, Wansheng Li, Yin Zi, Yue Chi, Jinling Wang, Wei Zheng, Qingjian Zou, Liangxue Lai, Chengcheng Tang   +11 more
doaj   +1 more source

Virological and Parasitological Characterization of Mini-LEWE Minipigs Using Improved Screening Methods and an Overview of Data on Various Minipig Breeds

Microorganisms, 2021
Minipigs play an important role in biomedical research and have also been used as donor animals in xenotransplantation. To serve as a donor in xenotransplantation, the animals must be free of potential zoonotic viruses, bacteria and parasites.
Sabrina Halecker, Julia Metzger, Christina Strube, Ludwig Krabben, Benedikt Kaufer, Joachim Denner   +5 more
doaj   +1 more source

Virus Safety of Xenotransplantation

Viruses, 2022
The practice of xenotransplantation using pig islet cells or organs is under development to alleviate the shortage of human donor islet cells or organs for the treatment of diabetes or organ failure.
Joachim Denner
doaj   +1 more source

Microchimerism, PERV and Xenotransplantation

Viruses, 2023
Microchimerism is the presence of cells in an individual that have originated from a genetically distinct individual. The most common form of microchimerism is fetomaternal microchimerism, i.e., cells from a fetus pass through the placenta and establish ...
Joachim Denner
doaj   +1 more source