Detection of non-reference porcine endogenous retrovirus loci in the Vietnamese native pig genome
Scientific Reports, 2022 The Vietnamese native pig (VnP)—a porcine breed with a small body—has proven suitable as a biomedical animal model. Here, we demonstrate that, compared to other breeds, VnPs have fewer copies of porcine endogenous retroviruses (PERVs), which pose a risk ...
Shinya Ishihara +7 more
doaj +1 more source
The restriction of zoonotic PERV transmission by human APOBEC3G. [PDF]
PLoS ONE, 2007 The human APOBEC3G protein is an innate anti-viral factor that can dominantly inhibit the replication of some endogenous and exogenous retroviruses. The prospects of purposefully harnessing such an anti-viral defense are under investigation.
Stefán R Jónsson +5 more
doaj +1 more source
Recombination analysis of human-tropic porcine endogenous retroviruses
Journal of General Virology, 2003 Prevention of cross-species infection of porcine endogenous retroviruses (PERV) is crucial for xenotransplantation. The potential risk of infection is caused by replication-competent PERV as well as by hybrid viruses derived from recombination events of distinct PERV genomes.
Nikolai, Klymiuk +3 more
openaire +2 more sources
Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing
Animal Research and One Health, EarlyView.Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley +1 more source
Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5 proteins including human TRIM5 [PDF]
, 2009 The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5{
Takeuchi, Y. +5 more
core
Cell Transplantation, 2004 The discovery of porcine endogenous retroviruses (PERV) has raised concerns regarding the safety of porcine xenotransplantation. However, transmission of PERV had not been observed in humans exposed to porcine tissue.
Brice W. Mckane +5 more
doaj +1 more source
Genotyping of Porcine Endogenous Retroviruses from a Family of Miniature Swine [PDF]
Journal of Virology, 2004 ABSTRACT The identification of animals in an inbred miniature swine herd that consistently fail to produce replication- competent humantropic porcine endogenous retrovirus (PERV) has prompted studies on the biology of PERV in transmitter and nontransmitter animals.
Gary, Quinn +6 more
openaire +2 more sources
Cell entry and exit of porcine endogenous retrovirus A: receptors and release inhibitor [PDF]
, 2010 Following the discovery that porcine endogenous retrovirus (PERV) can infect human cells, the potential risk of a zoonotic infection by PERV has been a major obstacle in the xenotransplantation field.
Mattiuzzo, G.
core
Porcine Endogenous Retroviruses Inhibit Human Immune Cell Function: Risk for Xenotransplantation? [PDF]
, 2000 Transgenic pigs are currently the most favored potential source of organs for xenotransplantation. Like all mammalian species they all harbor endogenous retroviruses in their genome. These porcine endogenous retroviruses (PERVs) are produced from several
Tacke, Stefan J. +2 more
core +1 more source
Genetically engineered pigs for xenotransplantation: Hopes and challenges
Frontiers in Cell and Developmental Biology, 2023 The shortage of donor resources has greatly limited the application of clinical xenotransplantation. As such, genetically engineered pigs are expected to be an ideal organ source for xenotransplantation.
Jiahui Xi +5 more
doaj +1 more source