Results 31 to 40 of about 517,815 (166)

Efficient and Safe Editing of Porcine Endogenous Retrovirus Genomes by Multiple-Site Base-Editing Editor

Cells, 2022
Gene-modified miniature pigs serve as alternative tissue and organ donors for xenotransplantation to alleviate the shortage of human allogenic organs.
Shuwen Zheng, Haiwen Zhong, Xiaoqing Zhou, Min Chen, Wansheng Li, Yin Zi, Yue Chi, Jinling Wang, Wei Zheng, Qingjian Zou, Liangxue Lai, Chengcheng Tang   +11 more
doaj   +1 more source

Virological and Parasitological Characterization of Mini-LEWE Minipigs Using Improved Screening Methods and an Overview of Data on Various Minipig Breeds

Microorganisms, 2021
Minipigs play an important role in biomedical research and have also been used as donor animals in xenotransplantation. To serve as a donor in xenotransplantation, the animals must be free of potential zoonotic viruses, bacteria and parasites.
Sabrina Halecker, Julia Metzger, Christina Strube, Ludwig Krabben, Benedikt Kaufer, Joachim Denner   +5 more
doaj   +1 more source

Microchimerism, PERV and Xenotransplantation

Viruses, 2023
Microchimerism is the presence of cells in an individual that have originated from a genetically distinct individual. The most common form of microchimerism is fetomaternal microchimerism, i.e., cells from a fetus pass through the placenta and establish ...
Joachim Denner
doaj   +1 more source

Virus Safety of Xenotransplantation

Viruses, 2022
The practice of xenotransplantation using pig islet cells or organs is under development to alleviate the shortage of human donor islet cells or organs for the treatment of diabetes or organ failure.
Joachim Denner
doaj   +1 more source

Virological Characterization of Pigs with Erythema Multiforme

Microorganisms, 2022
Erythema multiforme in pigs is an acute, self-limiting disease characterized by red skin areas and often associated with anorexia, fever and respiratory problems. The cause of the disease remains unknown.
Sabrina Halecker, Vasileios Papatsiros, Dimitra Psalla, Ludwig Krabben, Benedikt Kaufer, Joachim Denner   +5 more
doaj   +1 more source

Evidence for Microchimerism in Baboon Recipients of Pig Hearts

Viruses, 2023
Xenotransplantation, like allotransplantation, is usually associated with microchimerism, i.e., the presence of cells from the donor in the recipient.
Hina Jhelum, Martin Bender, Bruno Reichart, Maren Mokelke, Julia Radan, Elisabeth Neumann, Ludwig Krabben, Jan-Michael Abicht, Benedikt Kaufer, Matthias Längin, Joachim Denner   +10 more
doaj   +1 more source

Role of DNA methylation in expression and transmission of porcine endogenous retroviruses. [PDF]

J Virol, 2013
ABSTRACT Porcine endogenous retroviruses (PERV) represent a major safety concern in pig-to-human xenotransplantation. To date, no PERV infection of a xenograft recipient has been recorded; however, PERVs are transmissible to human cells in vitro .
Matousková M, Vesely P, Daniel P, Mattiuzzo G, Hector RD, Scobie L, Takeuchi Y, Hejnar J.   +7 more
europepmc   +5 more sources

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Determinants of High Titer in Recombinant Porcine Endogenous Retroviruses [PDF]

Journal of Virology, 2004
ABSTRACT Porcine endogenous retroviruses (PERVs) pose a potential stumbling block for therapeutic xenotransplantation, with the greatest threat coming from viruses generated by recombination between members of the PERV subgroup A (PERV-A) and PERV-C families (PERV-A/C recombinants).
Ian, Harrison, Yasuhiro, Takeuchi, Birke, Bartosch, Jonathan P, Stoye   +3 more
openaire   +2 more sources

A paradigm for virus-host coevolution: sequential counter-adaptations between endogenous and exogenous retroviruses [PDF]

, 2007
Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections of the host germline transmitted 1vertically from generation to generation. It is hypothesized that some ERVs are used by the host as 1restriction factors to block the infection
Pereira, Filipe, LEYMASTER K, Pereira, P., Golder, Matthew, James C Demartini, Leymaster, Kreg, Mura, M., Mura, Manuela, Golder, M., Biek, R., Pereira Filipe, Golder, Matthew C., Arnaud, Frederick, Bernardo Chessa, Yu Li, CAPORALE M, Zhang, Y-P., Matthew Golder, Thomas E Spencer, Caporale Marco, Palmarini, Massimo, Alberti Alberto, Yu, Li, Arnaud Frederick, Biek Roman, Frederick Arnaud, Alberti, A., Arnaud, F., Spencer Thomas E, Ya-Ping Zhang, SPENCER T. E, Caporale, M., Li Yu, Palmarini, M., Varela, M., Kreg Leymaster, PEREIRA F, DeMartini, J.C., Zhang, Ya-ping, Mariana Varela, Spencer, T.E., ZHANG Y. P, Chessa, B., Chessa Bernardo, Mura Manuela, Alberto Alberti, Roman Biek, Varela Mariana, Leymaster Kreg, Spencer, Thomas,, ARNAUD F, BIEK R, Varela, Mariana, YU L, Golder Matthew, PALMARINI M., Chessa, Bernardo, Palmarini Massimo, Spencer, Thomas E., Manuela Mura, Biek, Roman, Spencer, Thomas E, DeMartini, James C., Leymaster, K., Filipe Pereira, Marco Caporale, Massimo Palmarini, Demartini, James, Demartini, James C, GOLDER M, DeMartini James C, Malim, Michael H, Yu, L., VARELA M, Caporale, Marco, Zhang Ya-ping, MURA M, DEMARTINI J. C, Alberti, Alberto   +78 more
core   +1 more source