Results 31 to 40 of about 3,386 (182)

Role of DNA methylation in expression and transmission of porcine endogenous retroviruses. [PDF]

J Virol, 2013
ABSTRACT Porcine endogenous retroviruses (PERV) represent a major safety concern in pig-to-human xenotransplantation. To date, no PERV infection of a xenograft recipient has been recorded; however, PERVs are transmissible to human cells in vitro .
Matousková M, Vesely P, Daniel P, Mattiuzzo G, Hector RD, Scobie L, Takeuchi Y, Hejnar J.   +7 more
europepmc   +6 more sources

Ancient origin and complex evolution of porcine endogenous retroviruses

Biosafety and Health, 2020
Porcine endogenous retroviruses (PERVs) are proviruses that have medical value in xenotransplantation. However, the evolutionary process leading to the generation of modern PERVs is not well understood.
Yicong Chen, Mingyue Chen, Jie Cui
exaly   +4 more sources

Xenotransplantation and Porcine Endogenous Retroviruses

Indian Journal of Kidney Diseases
Joachim Denner
doaj   +3 more sources

Characterizing and Mapping Porcine Endogenous Retroviruses in Westran Pigs [PDF]

Journal of Virology, 2002
ABSTRACTSince porcine endogenous retroviruses (PERVs) can infect cultured human cells, they are a potential hazard to xenotransplantation. For this reason, endogenous retroviruses from the Westran (Westmead Hospital transplantation) inbred line of pigs were analyzed by using consensus primers for the type A and type B viruses to amplify 1.8-kb envelope
Lee, J., Webb, G., Allen, R., Moran, C.
openaire   +4 more sources

Complex evolution of porcine endogenous retroviruses [PDF]

, 2019
Abstract Background: Porcine endogenous retroviruses (PERVs) are proviruses that can replicate in human cells. However, the evolutionary process leading to the generation of modern PERVs is not well understood.Results: We mined 14 pig genomes and other available 304 mammalian genomes in silico, which led to the documentation of 185 full-length ...
Yicong Chen, Mingyue Chen, Xiaoyan Duan, Jie Cui   +3 more
openaire   +2 more sources

Differential resistance to cell entry by porcine endogenous retrovirus subgroup A in rodent species [PDF]

Retrovirology, 2007
Background The risk of zoonotic infection by porcine endogenous retroviruses (PERV) has been highlighted in the context of pig-to-human xenotransplantation. The use of receptors for cell entry often determines the host range of retroviruses.
Takeuchi Yasuhiro, Matouskova Magda, Mattiuzzo Giada   +2 more
doaj   +2 more sources

Identification of a novel type C porcine endogenous retrovirus: evidence that copy number of endogenous retroviruses increases during host inbreeding.

Journal of General Virology, 2001
Different classes of porcine endogenous retroviruses (PERVs), which have the potential to infect humans during xenotransplantation, have been isolated from the pig genome.
R. Mang, J. Maas, Xianghong Chen, Jaap Goudsmit, A. C. Kuyl   +4 more
semanticscholar   +2 more sources

The porcine virome and xenotransplantation [PDF]

Virology Journal, 2017
The composition of the porcine virome includes viruses that infect pig cells, ancient virus-derived elements including endogenous retroviruses inserted in the pig chromosomes, and bacteriophages that infect a broad array of bacteria that inhabit pigs ...
Joachim Denner
doaj   +2 more sources

Lack of antibody response in pigs immunized with the transmembrane envelope protein of porcine endogenous retroviruses.

Journal of General Virology, 2014
Recently we immunised different mammalian species (goats, mice, rats, rabbits, guinea pigs, hamsters) with the recombinant ectodomain of the transmembrane envelope (TM) protein p15E of the porcine endogenous retrovirus (PERV).
Martina Keller, B. Petersen, H. Niemann, J. Denner   +3 more
semanticscholar   +2 more sources

Evolutionary Spread and Recombination of Porcine Endogenous Retroviruses in the Suiformes [PDF]

Journal of Virology, 2005
ABSTRACT Different Suiformes with increasing phylogenetic distance to the common pig ( Sus scrofa ) were assayed for the presence of porcine endogenous retroviruses (PERV) in general ( pol gene), while the distribution of long terminal repeat (LTR) types ...
Niebert, Marcus, Tonjes, Ralf R.
openaire   +6 more sources