Results 31 to 40 of about 5,388 (193)

Removal of Porcine Endogenous Retroviruses in Decellularized Liver Bioscaffolds. [PDF]

Xenotransplantation
ABSTRACT Tissue engineering using decellularized liver scaffolds presents a promising approach in regenerative medicine, offering a potential alternative to donor organ transplantation. The use of human livers as a bioscaffold is restricted by their limited availability and quality.
van Hengel EVA, Drabek D, Roest HP, Willemse J, Reniers LJ, Stallmann H, de Jonge J, Grosveld FG, van der Laan LJW, Verstegen MMA.   +9 more
europepmc   +2 more sources

Infection barriers to successful xenotransplantation focusing on porcine endogenous retroviruses. [PDF]

Clin Microbiol Rev, 2012
SUMMARY Xenotransplantation may be a solution to overcome the shortage of organs for the treatment of patients with organ failure, but it may be associated with the transmission of porcine microorganisms and the development of xenozoonoses. Whereas most microorganisms may be eliminated by pathogen-free breeding of the donor animals, porcine ...
Denner J, Tönjes RR.
europepmc   +5 more sources

Virological Characterization of Pigs with Erythema Multiforme

Microorganisms, 2022
Erythema multiforme in pigs is an acute, self-limiting disease characterized by red skin areas and often associated with anorexia, fever and respiratory problems. The cause of the disease remains unknown.
Sabrina Halecker, Vasileios Papatsiros, Dimitra Psalla, Ludwig Krabben, Benedikt Kaufer, Joachim Denner   +5 more
doaj   +1 more source

Evidence for Microchimerism in Baboon Recipients of Pig Hearts

Viruses, 2023
Xenotransplantation, like allotransplantation, is usually associated with microchimerism, i.e., the presence of cells from the donor in the recipient.
Hina Jhelum, Martin Bender, Bruno Reichart, Maren Mokelke, Julia Radan, Elisabeth Neumann, Ludwig Krabben, Jan-Michael Abicht, Benedikt Kaufer, Matthias Längin, Joachim Denner   +10 more
doaj   +1 more source

Porcine Corneal Tissue and Xenozoonotic Risks: A Review of the Current Evidence. [PDF]

Xenotransplantation
ABSTRACT Corneal opacities affect millions worldwide, with corneal transplantation as the primary treatment. However, donor shortages remain a challenge, leaving thousands waiting for transplants. Xenotransplantation using porcine corneas has emerged as a promising alternative due to anatomical and physiological similarities with human corneas ...
Moreira R, Nascimento H, Martins TMDM, Barbieri G, Pires P, Carvalho LN, Rosa LR, Almeida A, Pessuti CL, Ferrer H, Gomes JÁP, Goulart E, Raia S, Belfort R.   +13 more
europepmc   +2 more sources

Liver Xenotransplantation: Ethical and Societal Implications. [PDF]

Xenotransplantation
ABSTRACT The shortage of transplantable livers and high waitlist mortality rates have accelerated the clinical translation of liver xenotransplantation. Recent milestones, including extracorporeal perfusion models and gene‐edited pig‐to‐human transplants in both decedents and living patients, indicate that clinical trials may be imminent.
Hurst DJ, Bobier CA, Padilla LA, Merlocco A, Meier RPH.   +4 more
europepmc   +2 more sources

The First Clinical Renal Xenotransplantation Study (EXPAND): Evaluating Safety, Function, and Zoonotic Risks. [PDF]

Health Care Sci
Health Care Science, Volume 4, Issue 6, Page 377-380, December 2025.
Nashan B.
europepmc   +2 more sources

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Characterization of porcine endogenous retrovirus expression in neonatal and adult pig pancreatic islets [PDF]

, 2017
BACKGROUND: Pig islets represent an alternative to the current modes of treatment for patients with diabetes. However, the concerns over pathogen transmission including that of PERV limit their immediate, widespread usage in humans.
Akiyoshi, Bittmann, Claire Crossan, Clemenceau, Clemenceau, Cooper, Denner, Denner, Denner, Dieckhoff, Fishman, Gazda, Guo, Irgang, Kimsa, Korbutt, Linda Scobie, Matsumoto, Mazurek, Moon, Morozov, Mourad, Mueller, Nizar I. Mourad, Patience, Pierre Gianello, Pizzato, Schuurman, Scobie, Spizzo, Sypniewski, Tacke, Tucker, Victoria Cruikshank, Wynyard, Wynyard, Zhang   +36 more
core   +1 more source

Highly Variable Genomic Landscape of Endogenous Retroviruses in the C57BL/6J Inbred Strain, Depending on Individual Mouse, Gender, Organ Type, and Organ Location. [PDF]

, 2017
Transposable repetitive elements, named the "TREome," represent ~40% of the mouse genome. We postulate that the germ line genome undergoes temporal and spatial diversification into somatic genomes in conjunction with the TREome activity.
Cho, Kiho, Greenhalgh, David, Lee, Kang-Hoon, Lim, Debora   +3 more
core   +2 more sources