An approach to the control of disease transmission in pig-to-human xenotransplantation. [PDF]
, 2000 : Although several major immunologic hurdles need to be overcome, the pig is currently considered the most likely source animal of cells, tissues and organs for transplantation into humans.
A. D. M. E. Osterhaus +57 more
core +7 more sources
Assessment of porcine endogenous retrovirus transmission across an alginate barrier used for the encapsulation of porcine islets [PDF]
, 2018 BACKGROUND: Subcutaneous implantation of a macroencapsulated patch containing human allogenic islets has been successfully used to alleviate type 1 diabetes mellitus (T1DM) in a human recipient without the need for immunosuppression.
Crossan, Claire +4 more
core +1 more source
The porcine virome and xenotransplantation
Virology Journal, 2017 The composition of the porcine virome includes viruses that infect pig cells, ancient virus-derived elements including endogenous retroviruses inserted in the pig chromosomes, and bacteriophages that infect a broad array of bacteria that inhabit pigs ...
Joachim Denner
doaj +1 more source
When should precaution prevail? : interests in (public) health, the risk of harm and xenotransplantation. [PDF]
, 2010 Xenotransplantation is an example of a developing biotechnology which highlights three differing interests in the health of the public; a specific interest in enhancing the health of individuals who require a particular procedure or treatment, a wider ...
Fovargue, Sara, Ost, Suzanne
core +1 more source
Cytotoxic Effects during Knock Out of Multiple Porcine Endogenous Retrovirus (PERV) Sequences in the Pig Genome by Zinc Finger Nucleases (ZFN) [PDF]
, 2015 Xenotransplantation has been proposed as a solution to the shortage of suitable human donors for transplantation and pigs are currently favoured as donor animals.
Denner, Joachim +2 more
core +8 more sources
Determinants of High Titer in Recombinant Porcine Endogenous Retroviruses [PDF]
Journal of Virology, 2004 ABSTRACT Porcine endogenous retroviruses (PERVs) pose a potential stumbling block for therapeutic xenotransplantation, with the greatest threat coming from viruses generated by recombination between members of the PERV subgroup A (PERV-A) and PERV-C families (PERV-A/C recombinants).
Ian, Harrison +3 more
openaire +2 more sources
Transmission of Porcine Endogenous Retrovirus Produced from Different Recipient Cells In Vivo. [PDF]
PLoS ONE, 2016 Humanized pigs have been developed to reduce the incidence of immune rejection in xenotransplantation, but significant concerns remain, such as transmission of viral zoonosis. Porcine endogenous retroviruses (PERV), which exist in the genome of pigs, are
Nayoung Kim +7 more
doaj +1 more source
Cellular xenotransplantation of animal cells into people: benefits and risk [PDF]
, 2018 The main benefit of xenotransplantation is its potential to overcome the worldwide organ shortage experienced in allotransplantation. Allogeneic transplantation is the only successful therapy for several life-threatening diseases, with cell, tissue or ...
Cozzi, Emanuele +4 more
core +1 more source
Characterizing and Mapping Porcine Endogenous Retroviruses in Westran Pigs [PDF]
Journal of Virology, 2002 ABSTRACTSince porcine endogenous retroviruses (PERVs) can infect cultured human cells, they are a potential hazard to xenotransplantation. For this reason, endogenous retroviruses from the Westran (Westmead Hospital transplantation) inbred line of pigs were analyzed by using consensus primers for the type A and type B viruses to amplify 1.8-kb envelope
Lee, J., Webb, G., Allen, R., Moran, C.
openaire +3 more sources
Parvovirus-derived endogenous viral elements in two South American rodent genomes [PDF]
, 2014 We describe endogenous viral elements (EVEs) derived from parvoviruses (family <i>Parvoviridae</i>) in the long-tailed chinchilla (<i>Chinchilla lanigera</i>) and degu (<i>Octodon degus</i>) genomes.
Abascal +20 more
core +1 more source