Results 41 to 50 of about 3,386 (182)

Xenoperfusion-The Transformative Role of Machine Perfusion in Xenotransplantation. [PDF]

Xenotransplantation
ABSTRACT Recent advances in xenotransplantation have gained substantial public and clinical attention as genetically modified porcine organs are now being transplanted into living human recipients. While only case reports have been published to date, the first clinical trials for kidney xenotransplantation are now ongoing.
Huwyler F, Stoerzer S, Clavien PA, Tibbitt MW.   +3 more
europepmc   +2 more sources

Characteristic features of porcine endogenous retroviruses in Vietnamese native pigs

Animal Science Journal, 2020
AbstractWe aimed to clarify the genomic characteristics of porcine endogenous retroviruses (PERVs) in Vietnamese native pig (VnP) breeds. First, we investigated genetic polymorphisms in β‐ and γ‐like PERVs, and we then measured the copy numbers of infectious γ‐like PERVs (PERV‐A, B, and C). We purified genomic DNA from 15 VnP breeds from 12 regions all
Shinya Ishihara, Thanh Q. Dang‐Nguyen, Kazuhiro Kikuchi, Aisaku Arakawa, Satoshi Mikawa, Makoto Osaki, Takeshige Otoi, Quang Minh Luu, Thanh Son Nguyen, Masaaki Taniguchi   +9 more
openaire   +4 more sources

Epigenetic marking and repression of porcine endogenous retroviruses

Journal of General Virology, 2013
Endogenous retroviruses (ERVs) are remnants of retroviral germ line infections and have been identified in all mammals investigated so far. Although the majority of ERVs are degenerated, some mammalian species, such as mice and pigs, carry replication-competent ERVs capable of forming infectious viral particles.
Wolf, Gernot, Mikkelsen, Jacob Giehm; id_orcid 0000-0002-1322-3209, Nielsen, Anders Lade; id_orcid 0000-0003-4372-9961, Pedersen, Finn Skou   +3 more
openaire   +4 more sources

Investigation of Polymorphisms Induced by the Solo Long Terminal Repeats (Solo-LTRs) in Porcine Endogenous Retroviruses (ERVs) [PDF]

Viruses
Homologous recombination events take place between the 5′ and 3′ long terminal repeats (LTRs) of ERVs, resulting in the generation of solo-LTR, which can cause solo-LTR-associated polymorphism across different genomes.
Cai Chen, Zhanyu Du, Yao Zheng, Hong Chen, Ahmed A. Saleh, Naisu Yang, Mengli Wang, Phiri Azele, Xiaoyan Wang, Chengyi Song   +9 more
doaj   +2 more sources

Generation of neutralising antibodies against porcine endogenous retroviruses (PERVs)

Virology, 2011
Antibodies neutralising porcine endogenous retroviruses (PERVs) were induced in different animal species by immunisation with the transmembrane envelope protein p15E. These antibodies recognised epitopes, designated E1, in the fusion peptide proximal region (FPPR) of p15E, and E2 in the membrane proximal external region (MPER).
Kaulitz, Danny, Fiebig, Uwe, Eschricht, Magdalena, Wurzbacher, Christian, Kurth, Reinhard, Denner, Joachim   +5 more
openaire   +3 more sources

Detection of non-reference porcine endogenous retrovirus loci in the Vietnamese native pig genome

Scientific Reports, 2022
The Vietnamese native pig (VnP)—a porcine breed with a small body—has proven suitable as a biomedical animal model. Here, we demonstrate that, compared to other breeds, VnPs have fewer copies of porcine endogenous retroviruses (PERVs), which pose a risk ...
Shinya Ishihara, Masahiko Kumagai, Aisaku Arakawa, Masaaki Taniguchi, Ngo Thi Kim Cuc, Lan Doan Pham, Satoshi Mikawa, Kazuhiro Kikuchi   +7 more
doaj   +2 more sources

Liver Xenotransplantation: Ethical and Societal Implications. [PDF]

Xenotransplantation
ABSTRACT The shortage of transplantable livers and high waitlist mortality rates have accelerated the clinical translation of liver xenotransplantation. Recent milestones, including extracorporeal perfusion models and gene‐edited pig‐to‐human transplants in both decedents and living patients, indicate that clinical trials may be imminent.
Hurst DJ, Bobier CA, Padilla LA, Merlocco A, Meier RPH.   +4 more
europepmc   +2 more sources

Genomic insights into evolutionary journey of the porcine endogenous retroviruses [PDF]

bioRxiv, 2018
Abstract Background Xenotransplantation may overcome significant shortage of human allotransplant. Porcine organs are considered favorable for xenotransplantation duo to similar size and function to human organ.
Chen, Yicong, Chen, Mingyue, Duan, Xiaoyan, Cui, Jie   +3 more
openaire   +2 more sources

Comprehensive Protocols for Detecting Xenotransplantation-Relevant Viruses [PDF]

Methods and Protocols
Xenotransplantation using pig cells, tissues, or organs is advancing toward clinical application to address the shortage of human donor organs for treating organ failure.
Hina Jhelum, Benedikt B. Kaufer, Joachim Denner   +2 more
doaj   +2 more sources

Monitoring for PERV Following Xenotransplantation [PDF]

Transplant International
Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs. PERV-A, PERV-B and PERV-C can be released as infectious virus particles and PERV-A and PERV-B can infect human cells in culture.
Joachim Denner
doaj   +2 more sources