Results 21 to 30 of about 3,386 (182)

Expression of porcine endogenous retroviruses (PERV) in different organs of a pig

Virology, 2012
Porcine endogenous retroviruses (PERVs) represent a particular risk for xenotransplantation using pig cells, tissues or organs. PERVs are integrated in the genome of all pig strains and can be released as particles that infect human cells. We performed for the first time a systematic analysis of PERV expression in different organs of a miniature pig ...
Iris Bittmann, Joachim Denner
exaly   +5 more sources

Retroviral Insertion Polymorphism (RIP) of Porcine Endogenous Retroviruses (PERVs) in Pig Genomes [PDF]

Animals
Endogenous retroviruses (ERVs) are one of the superfamilies of long terminal repeat retrotransposons (LTRs) in mice and humans. Approximately 8% of the pig genome is composed of sequences derived from LTRs. While the majority of ERVs in pigs have decayed,
Zhanyu Du, Cai Chen, Yao Zheng, Xiaoyan Wang, Chengyi Song   +4 more
doaj   +3 more sources

Porcine Endogenous Retroviruses: Quantification of the Viral Copy Number for the Four Miniature Pig Breeds in China [PDF]

Frontiers in Microbiology, 2022
Domestic pigs has served not only as one of the most important economy livestock but also as ideal organ-source animals owing to similarity in anatomy, physiology, and organ size to humans.
Tao-feng Lu, Bo Sun, Tai-yong Yu, Yan-jun Wu, Jie Zhou, Shu-guang Wu   +5 more
doaj   +3 more sources

Removal of Porcine Endogenous Retroviruses in Decellularized Liver Bioscaffolds. [PDF]

Xenotransplantation
ABSTRACT Tissue engineering using decellularized liver scaffolds presents a promising approach in regenerative medicine, offering a potential alternative to donor organ transplantation. The use of human livers as a bioscaffold is restricted by their limited availability and quality.
van Hengel EVA, Drabek D, Roest HP, Willemse J, Reniers LJ, Stallmann H, de Jonge J, Grosveld FG, van der Laan LJW, Verstegen MMA.   +9 more
europepmc   +4 more sources

Reliable Polymerase Chain Reaction Methods for Screening for Porcine Endogenous Retroviruses-C (PERV-C) in Pigs [PDF]

Viruses
Porcine endogenous retrovirus C (PERV-C) is a gammaretrovirus present in the genome of many, but not all, pigs. It is an ecotropic virus, able to infect only pig cells.
Hina Jhelum, Dusan Kunec, Vasileios Papatsiros, Benedikt B. Kaufer, Joachim Denner   +4 more
doaj   +3 more sources

Infection barriers to successful xenotransplantation focusing on porcine endogenous retroviruses. [PDF]

Clin Microbiol Rev, 2012
SUMMARY Xenotransplantation may be a solution to overcome the shortage of organs for the treatment of patients with organ failure, but it may be associated with the transmission of porcine microorganisms and the development of xenozoonoses. Whereas most microorganisms may be eliminated by pathogen-free breeding of the donor animals, porcine ...
Denner J, Tönjes RR.
europepmc   +7 more sources

Porcine endogenous retroviruses: an obstacle to cross during xenotransplantation [PDF]

BMC Infectious Diseases, 2012
Background Xenotransplantation involves the transplantation of nonhuman tissue or organs to humans. Worldwide shortage of organs for clinical applications has shifted the focus towards non-human sources. Pig represents a rich source of organ donors but the presence of porcine endogenous retroviruses (PERVs) represents a particular risk and considered ...
Senthilkumar Subramaniam, Guharthakurta Soma, Cherian Kotturathu   +2 more
doaj   +4 more sources

Porcine endogenous retroviruses in xenotransplantation

Nephrology Dialysis Transplantation
ABSTRACT Xenotransplantation using pig cells, tissues or organs is under development to alleviate the shortage of human donor organs. Meanwhile, remarkably long survival times of pig organs in non-human primates have been reported, as well as the functionality of pig kidneys and hearts in brain-dead humans.
Joachim Denner, Denner Joachim
exaly   +4 more sources

The Relationship between Embryonic Development and the Efficiency of Target Mutations in Porcine Endogenous Retroviruses (PERVs) Pol Genes in Porcine Embryos [PDF]

Animals, 2019
Porcine endogenous retrovirus (PERV) is a provirus found in the pig genome that may act as an infectious pathogen in humans who receive pig organ xenotransplantation.
Maki Hirata, Manita Wittayarat, Takayuki Hirano, Nhien Thi Nguyen, Quynh Anh Le, Zhao Namula, Mokhamad Fahrudin, Fuminori Tanihara, Takeshige Otoi   +8 more
doaj   +3 more sources

Characterization of Insertional Variation of Porcine Endogenous Retroviruses in Six Different Pig Breeds [PDF]

Asian-Australasian Journal of Animal Sciences, 2012
Pigs may need to be exploited as xenotransplantation donors due to the shortage of human organs, tissues and cells. Porcine endogenous retroviruses (PERVs) are a significant obstacle to xenotransplantation because they can infect human cells in vitro and
W. Y. Jung, S. L. Yu, D. W. Seo, K. C. Jung, I. C. Cho, H. T. Lim, D. I. Jin, J. H. Lee   +7 more
doaj   +3 more sources