Results 21 to 30 of about 517,815 (166)

Reliable Polymerase Chain Reaction Methods for Screening for Porcine Endogenous Retroviruses-C (PERV-C) in Pigs [PDF]

Viruses
Porcine endogenous retrovirus C (PERV-C) is a gammaretrovirus present in the genome of many, but not all, pigs. It is an ecotropic virus, able to infect only pig cells.
Hina Jhelum, Dusan Kunec, Vasileios Papatsiros, Benedikt B. Kaufer, Joachim Denner   +4 more
doaj   +2 more sources

Increased titers of neutralizing antibodies after immunization with both envelope proteins of the porcine endogenous retroviruses (PERVs) [PDF]

Virology Journal, 2012
Despite enormous difficulties to induce antibodies neutralizing HIV-1, especially broadly neutralizing antibodies directed against the conserved membrane proximal external region (MPER) of the transmembrane envelope protein, such antibodies can be easily
Denner Joachim, Mihica Debora, Kaulitz Danny, Schmidt Christa-Maria   +3 more
doaj   +2 more sources

The Relationship between Embryonic Development and the Efficiency of Target Mutations in Porcine Endogenous Retroviruses (PERVs) Pol Genes in Porcine Embryos [PDF]

Animals, 2019
Porcine endogenous retrovirus (PERV) is a provirus found in the pig genome that may act as an infectious pathogen in humans who receive pig organ xenotransplantation.
Maki Hirata, Manita Wittayarat, Takayuki Hirano, Nhien Thi Nguyen, Quynh Anh Le, Zhao Namula, Mokhamad Fahrudin, Fuminori Tanihara, Takeshige Otoi   +8 more
doaj   +2 more sources

Investigation of Polymorphisms Induced by the Solo Long Terminal Repeats (Solo-LTRs) in Porcine Endogenous Retroviruses (ERVs) [PDF]

Viruses
Homologous recombination events take place between the 5′ and 3′ long terminal repeats (LTRs) of ERVs, resulting in the generation of solo-LTR, which can cause solo-LTR-associated polymorphism across different genomes.
Cai Chen, Zhanyu Du, Yao Zheng, Hong Chen, Ahmed A. Saleh, Naisu Yang, Mengli Wang, Phiri Azele, Xiaoyan Wang, Chengyi Song   +9 more
doaj   +2 more sources

Global Consultation for Clinical Xenotransplantation: International Xenotransplantation Association Consensus and Communiqué Update. [PDF]

Xenotransplantation
ABSTRACT Xenotransplantation has entered a phase of accelerated clinical translation, necessitating renewed international consensus on governance, ethics, safety, and regulatory oversight. In September 2025, the International Xenotransplantation Association (IXA), in partnership with The Transplantation Society (TTS) and with engagement from the World ...
Hawthorne WJ, Wolf E, Cowan PJ, Wang W, Yun IJ, Brenner P, Korbutt G, Meier RPH, Sykes M, Bühler LH, Scobie L, Garkavenko O, Kim H, Hurst DJ, Iii RNP, Rieben R, Pascual M, Scholes-Robertson N, Cozzi E, Abalovich A, Loupy A, Hara H, Bottino R, Ekser B, Mohiuddin MM, Fishman J.   +25 more
europepmc   +2 more sources

Generation of neutralising antibodies against porcine endogenous retroviruses (PERVs) [PDF]

Virology, 2011
Antibodies neutralising porcine endogenous retroviruses (PERVs) were induced in different animal species by immunisation with the transmembrane envelope protein p15E. These antibodies recognised epitopes, designated E1, in the fusion peptide proximal region (FPPR) of p15E, and E2 in the membrane proximal external region (MPER).
Kaulitz, Danny, Fiebig, Uwe, Eschricht, Magdalena, Wurzbacher, Christian, Kurth, Reinhard, Denner, Joachim   +5 more
openaire   +3 more sources

Advancing Type 1 Diabetes Treatment: 3 PM-Oriented Innovations in Islet Transplantation and Biomaterial Engineering. [PDF]

Diabetes Metab Res Rev
ABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Sabet Sarvestani F, Yaghobi R, Khosravi Maharlooei M, Golshan M, Karimi MH.   +4 more
europepmc   +2 more sources

Xenotransplantation and Porcine Endogenous Retroviruses

Indian Journal of Kidney Diseases
Joachim Denner
doaj   +2 more sources

Co-Cultivation Assays for Detecting Infectious Human-Tropic Porcine Endogenous Retroviruses (PERVs) [PDF]

International Journal of Molecular Sciences
Joachim Denner
exaly   +2 more sources

Structure of the Core Postfusion Porcine Endogenous Retrovirus Fusion Protein

mBio, 2022
Retroviral elements from endogenous retroviruses have functions in mammalian physiology. The best-known examples are the envelope proteins that function in placenta development and immune suppression.
Trevor T. Dean, Vitor Hugo B. Serrão, Jeffrey E. Lee   +2 more
doaj   +1 more source