Removal of Porcine Endogenous Retroviruses in Decellularized Liver Bioscaffolds [PDF]
XenotransplantationABSTRACT Tissue engineering using decellularized liver scaffolds presents a promising approach in regenerative medicine, offering a potential alternative to donor organ transplantation. The use of human livers as a bioscaffold is restricted by their limited availability and quality.
van Hengel EVA +9 more
exaly +5 more sources
Ancient origin and complex evolution of porcine endogenous retroviruses
Biosafety and Health, 2020 Porcine endogenous retroviruses (PERVs) are proviruses that have medical value in xenotransplantation. However, the evolutionary process leading to the generation of modern PERVs is not well understood.
Jie Cui, Mingyue Chen, Yicong Chen
exaly +4 more sources
[Endogenous porcine retroviruses and xenotransplantation].
Pathologie-biologie, 2000 Vertebrate DNA contains numerous genomes closely related to retroviruses, i.e. endogenous retroviruses. While most of the retroviruses are pathogenous, endogenous retroviruses have rarely been shown as such. Endogenous retroviruses, as most of the retroviruses, are able to cross 'species barriers'. Porcine endogenous retroviruses were described in 1974.
Mornex, Jean-Francois
core +10 more sources
Porcine endogenous retroviruses: an obstacle to cross during xenotransplantation [PDF]
BMC Infectious Diseases, 2012 Background Xenotransplantation involves the transplantation of nonhuman tissue or organs to humans. Worldwide shortage of organs for clinical applications has shifted the focus towards non-human sources. Pig represents a rich source of organ donors but the presence of porcine endogenous retroviruses (PERVs) represents a particular risk and considered ...
Senthilkumar Subramaniam +2 more
doaj +4 more sources
Infection barriers to successful xenotransplantation focusing on porcine endogenous retroviruses. [PDF]
Clin Microbiol Rev, 2012 SUMMARY Xenotransplantation may be a solution to overcome the shortage of organs for the treatment of patients with organ failure, but it may be associated with the transmission of porcine microorganisms and the development of xenozoonoses. Whereas most microorganisms may be eliminated by pathogen-free breeding of the donor animals, porcine ...
Denner J, Tönjes RR.
europepmc +7 more sources
Characterizing and Mapping Porcine Endogenous Retroviruses in Westran Pigs [PDF]
Journal of Virology, 2002 ABSTRACTSince porcine endogenous retroviruses (PERVs) can infect cultured human cells, they are a potential hazard to xenotransplantation. For this reason, endogenous retroviruses from the Westran (Westmead Hospital transplantation) inbred line of pigs were analyzed by using consensus primers for the type A and type B viruses to amplify 1.8-kb envelope
Lee, J., Webb, G., Allen, R., Moran, C.
openaire +4 more sources
Characterization of Insertional Variation of Porcine Endogenous Retroviruses in Six Different Pig Breeds [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 Pigs may need to be exploited as xenotransplantation donors due to the shortage of human organs, tissues and cells. Porcine endogenous retroviruses (PERVs) are a significant obstacle to xenotransplantation because they can infect human cells in vitro and
W. Y. Jung +7 more
doaj +2 more sources
Differential resistance to cell entry by porcine endogenous retrovirus subgroup A in rodent species [PDF]
Retrovirology, 2007 Background The risk of zoonotic infection by porcine endogenous retroviruses (PERV) has been highlighted in the context of pig-to-human xenotransplantation. The use of receptors for cell entry often determines the host range of retroviruses.
Takeuchi Yasuhiro +2 more
doaj +2 more sources
Detection of Pig Cells Harboring Porcine Endogenous Retroviruses in Non-Human Primate Bladder After Renal Xenotransplantation [PDF]
Viruses, 2019 Pigs are used as potential donor animals for xenotransplantation. However, porcine endogenous retrovirus (PERV), shown to infect both human and non-human primate (NHP) cells in vitro, presents a risk of transmission to humans in xenotransplantation.
Yoonki Heo +9 more
doaj +2 more sources
Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology [PDF]
Health Care SciBringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Saha S, Dutta M, Bosu A.
europepmc +2 more sources