Porcine endogenous retroviruses: an obstacle to cross during xenotransplantation [PDF]
BMC Infectious Diseases, 2012 Background Xenotransplantation involves the transplantation of nonhuman tissue or organs to humans. Worldwide shortage of organs for clinical applications has shifted the focus towards non-human sources. Pig represents a rich source of organ donors but the presence of porcine endogenous retroviruses (PERVs) represents a particular risk and considered ...
Senthilkumar Subramaniam +2 more
doaj +4 more sources
Ancient origin and complex evolution of porcine endogenous retroviruses
Biosafety and Health, 2020 Porcine endogenous retroviruses (PERVs) are proviruses that have medical value in xenotransplantation. However, the evolutionary process leading to the generation of modern PERVs is not well understood.
Yicong Chen +3 more
doaj +2 more sources
Genome-wide inactivation of porcine endogenous retroviruses (PERVs) [PDF]
Science, 2015 Virally cleansing the pig genome Transplants from pigs could be a solution to a shortage of human organs for transplantation. Unfortunately, porcine endogenous retroviruses (PERVs) are rife in pigs and can be transmitted to humans, risking disease. L. Yang et al.
Luhan Yang, Marc Güell, Dong Niu
exaly +4 more sources
Differential resistance to cell entry by porcine endogenous retrovirus subgroup A in rodent species [PDF]
Retrovirology, 2007 Background The risk of zoonotic infection by porcine endogenous retroviruses (PERV) has been highlighted in the context of pig-to-human xenotransplantation. The use of receptors for cell entry often determines the host range of retroviruses.
Takeuchi Yasuhiro +2 more
doaj +3 more sources
Characterization of Insertional Variation of Porcine Endogenous Retroviruses in Six Different Pig Breeds [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 Pigs may need to be exploited as xenotransplantation donors due to the shortage of human organs, tissues and cells. Porcine endogenous retroviruses (PERVs) are a significant obstacle to xenotransplantation because they can infect human cells in vitro and
W. Y. Jung +7 more
doaj +2 more sources
Detection of Pig Cells Harboring Porcine Endogenous Retroviruses in Non-Human Primate Bladder After Renal Xenotransplantation [PDF]
Viruses, 2019 Pigs are used as potential donor animals for xenotransplantation. However, porcine endogenous retrovirus (PERV), shown to infect both human and non-human primate (NHP) cells in vitro, presents a risk of transmission to humans in xenotransplantation.
Yoonki Heo +9 more
doaj +2 more sources
Increased titers of neutralizing antibodies after immunization with both envelope proteins of the porcine endogenous retroviruses (PERVs) [PDF]
Virology Journal, 2012 Despite enormous difficulties to induce antibodies neutralizing HIV-1, especially broadly neutralizing antibodies directed against the conserved membrane proximal external region (MPER) of the transmembrane envelope protein, such antibodies can be easily
Denner Joachim +3 more
doaj +2 more sources
Reliable Polymerase Chain Reaction Methods for Screening for Porcine Endogenous Retroviruses-C (PERV-C) in Pigs [PDF]
VirusesPorcine endogenous retrovirus C (PERV-C) is a gammaretrovirus present in the genome of many, but not all, pigs. It is an ecotropic virus, able to infect only pig cells.
Hina Jhelum +4 more
doaj +2 more sources
The Relationship between Embryonic Development and the Efficiency of Target Mutations in Porcine Endogenous Retroviruses (PERVs) Pol Genes in Porcine Embryos [PDF]
Animals, 2019 Porcine endogenous retrovirus (PERV) is a provirus found in the pig genome that may act as an infectious pathogen in humans who receive pig organ xenotransplantation.
Maki Hirata +8 more
doaj +2 more sources
Investigation of Polymorphisms Induced by the Solo Long Terminal Repeats (Solo-LTRs) in Porcine Endogenous Retroviruses (ERVs) [PDF]
VirusesHomologous recombination events take place between the 5′ and 3′ long terminal repeats (LTRs) of ERVs, resulting in the generation of solo-LTR, which can cause solo-LTR-associated polymorphism across different genomes.
Cai Chen +9 more
doaj +2 more sources