Results 131 to 140 of about 515,911 (152)
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Porcine endogenous retroviruses (PERVs) and xenotransplantation
Deutsche Medizinische Wochenschrift, 2003exaly +2 more sources
Xenotransplantation, 2001
Abstract: Xenotransplantation may be associated with the risk of transmission of microorganisms. In particular, the porcine endogenous retroviruses (PERV) have raised concerns as in vitro experiments show susceptibility of human cells for PERV infection.
Joachim Denner, K Boller
exaly +3 more sources
Abstract: Xenotransplantation may be associated with the risk of transmission of microorganisms. In particular, the porcine endogenous retroviruses (PERV) have raised concerns as in vitro experiments show susceptibility of human cells for PERV infection.
Joachim Denner, K Boller
exaly +3 more sources
Archives of Virology, 2006
A potential risk in pig-to-human xenotransplantation is the transmission of PERVs to human recipients. Here we show for the first time the inhibition of PERV expression in primary porcine cells by RNA interference using lentiviral vectors. Cells were transduced with lentiviral vectors coding for short hairpin (sh) RNAs directed against PERV.
B, Dieckhoff +8 more
openaire +2 more sources
A potential risk in pig-to-human xenotransplantation is the transmission of PERVs to human recipients. Here we show for the first time the inhibition of PERV expression in primary porcine cells by RNA interference using lentiviral vectors. Cells were transduced with lentiviral vectors coding for short hairpin (sh) RNAs directed against PERV.
B, Dieckhoff +8 more
openaire +2 more sources
Porcine Endogenous Retroviruses in Xenotransplantation
2011Organ transplant is an effective therapy for end-stage organ failure but is currently limited by the shortage of human donors. The possibility that animals could provide an alternative source of donor organs and cells or tissue, a process known as xenotransplantation, has stimulated much debate, with general agreement that the pig is the most promising
Scobie, Linda, Garkavenko, Olga
openaire +1 more source
Recombinant porcine endogenous retroviruses (PERV-A/C): a new risk for xenotransplantation?
Archives of Virology, 2008The zoonotic transmissions from non‐human primates of the human immunodeficiency virus (HIV‐1) that initiated the AIDS pandemic and the spread of many emerging infectious diseases teaches us that there is a need for carefully consider the potential risks associated with xenotransplantation. Whereas known viruses can easily be eliminated from donor pigs
openaire +2 more sources
Virus Research, 2004
PCR amplification of proviral DNA extracted from peripheral blood lymphocytes of three Chinese pigs (Banna minipig inbreed (BMI), Wu-Zhi-Shan pig (WZSP) and Neijiang pig (NJP)), using primers corresponding to highly conserved regions of reverse transcriptase (RT) of pol gene and nucleocapsid sequence of gag gene.
Zhang, Li +6 more
openaire +2 more sources
PCR amplification of proviral DNA extracted from peripheral blood lymphocytes of three Chinese pigs (Banna minipig inbreed (BMI), Wu-Zhi-Shan pig (WZSP) and Neijiang pig (NJP)), using primers corresponding to highly conserved regions of reverse transcriptase (RT) of pol gene and nucleocapsid sequence of gag gene.
Zhang, Li +6 more
openaire +2 more sources
Asian-Australasian Journal of Animal Sciences, 2007 Porcine Endogenous Retroviruses (PERVs) are a major concern in relation to xenotransplantation. Previous research indicated that PERVs are present at about 50 copies in the pig genome and their chromosomal insertion sites are different among pig breeds.
Claire Rogel-Gaillard +2 more
exaly +3 more sources
Archives of Virology, 2002
Porcine endogenous retroviruses (PERVs) are considered a special risk for xenotransplantation because they are an integral part of the porcine genome and are able to infect cells of numerous species including humans in vitro. Among these cells, the mink lung epithelial cell line Mv1Lu could be productively infected with PERV.
V, Specke +4 more
openaire +2 more sources
Porcine endogenous retroviruses (PERVs) are considered a special risk for xenotransplantation because they are an integral part of the porcine genome and are able to infect cells of numerous species including humans in vitro. Among these cells, the mink lung epithelial cell line Mv1Lu could be productively infected with PERV.
V, Specke +4 more
openaire +2 more sources