Results 141 to 150 of about 882 (164)

Phylogenetic relationship of porcine endogenous retrovirus (PERV) in Chinese pigs with some type C retroviruses

Virus Research, 2004
PCR amplification of proviral DNA extracted from peripheral blood lymphocytes of three Chinese pigs (Banna minipig inbreed (BMI), Wu-Zhi-Shan pig (WZSP) and Neijiang pig (NJP)), using primers corresponding to highly conserved regions of reverse transcriptase (RT) of pol gene and nucleocapsid sequence of gag gene.
Zhang, Li, Yu, Ping, Li, Shengfu, Bu, Hong, Li, Youping, Zeng, Yangzhi, Cheng, Jingqiu   +6 more
openaire   +2 more sources

Recombinant porcine endogenous retroviruses (PERV-A/C): a new risk for xenotransplantation?

Archives of Virology, 2008
The zoonotic transmissions from non‐human primates of the human immunodeficiency virus (HIV‐1) that initiated the AIDS pandemic and the spread of many emerging infectious diseases teaches us that there is a need for carefully consider the potential risks associated with xenotransplantation. Whereas known viruses can easily be eliminated from donor pigs
openaire   +2 more sources

Porcine Endogenous Retroviruses in Xenotransplantation

2011
Organ transplant is an effective therapy for end-stage organ failure but is currently limited by the shortage of human donors. The possibility that animals could provide an alternative source of donor organs and cells or tissue, a process known as xenotransplantation, has stimulated much debate, with general agreement that the pig is the most promising
Scobie, Linda, Garkavenko, Olga
openaire   +1 more source

Productive infection of a mink cell line with porcine endogenous retroviruses (PERVs) but lack of transmission to minks in vivo

Archives of Virology, 2002
Porcine endogenous retroviruses (PERVs) are considered a special risk for xenotransplantation because they are an integral part of the porcine genome and are able to infect cells of numerous species including humans in vitro. Among these cells, the mink lung epithelial cell line Mv1Lu could be productively infected with PERV.
V, Specke, R, Plesker, C, Coulibaly, K, Boller, J, Denner   +4 more
openaire   +2 more sources

[Porcine endogenous retroviruses (PERV): in vitro artifact or a big problem for xenotransplantation?].

DTW. Deutsche tierarztliche Wochenschrift, 1999
The pig is the favorized donor species for clinical xenotransplantation. However, PATIENCE et al. could show, that porcine endogenous retroviruses (PERV), released by a porcine kidney cell line, are capable of infecting human cell lines in vitro. Based on this discovery there is an ongoing discussion concerning the risks of zoonosis combined with ...
U, Martin, G, Steinhoff
openaire   +1 more source

Umbilical Cord Blood Stem Cells Induced into Myeloid, Erythroid, or Megakaryocytic Pathways Are Susceptible to Infection by Porcine Endogenous Retroviruses (PERV).

Blood, 2005
Abstract Susceptibility of human hematopoietic stem cells to infection with porcine endogenous retroviruses (PERV) is of prime importance in determining the feasibility and safety of transplanting pig organs into humans. Under the influence of lineage specific cytokines, umbilical cord blood stem cells were evaluated for their ...
Carolyn A. Wilson, Takele Argaw, Doris A. Morgan   +2 more
openaire   +1 more source

Antiviral Activity of Reverse Transcriptase Inhibitors against Porcine Endogenous Retroviruses (PERV)

Antiviral Research, 2007
M SHI, X WANG, E DECLERCQ, S TAKAO, M BABA   +4 more
openaire   +1 more source

Porcine endogenous retroviruses (PERVs) and xenotransplantation

DMW - Deutsche Medizinische Wochenschrift, 2003
openaire   +1 more source

Transmission of porcine endogenous retroviruses (PERVs): Animal models and inhibition by RNA interference

Xenotransplantation, 2007
Britta Dieckhoff, Alexander Karlas, Björn Petersen, Wilfried A. Kues, Reinhard Kurth, Heiner Niemann, Joachim Denner   +6 more
openaire   +1 more source

PHYLOGENETIC RELATIONSHIP OF PORCINE ENDOGENOUS RETROVIRUS (PERV) IN CHINESE PIGS WITH OTHER PATHOGENIC TYPE C RETROVIRUSES

Transplantation, 2004
L Zhang, P Yu, S F. Li, H Bu, Y P. Li, J Q. Cheng, Y Z. Zeng   +6 more
openaire   +1 more source