Results 121 to 130 of about 515,911 (152)

The use of transgenic animals for xenotransplantation: An update. [PDF]

Animal Model Exp Med
Motławska J, Amaral A, Cerveira-Pinto M, Kordowitzki P.   +3 more
europepmc   +1 more source

Species-Specific Transcription Factors Associated with Long Terminal Repeat Promoters of Endogenous Retroviruses: A Comprehensive Review. [PDF]

Biomolecules
Hossain MJ, Nyame P, Monde K.
europepmc   +1 more source

Mitigating Cross-Species Viral Infections in Xenotransplantation: Progress, Strategies, and Clinical Outlook. [PDF]

Cell Transplant
Zhou Y, Zhou S, Wang Q, Zhang B.
europepmc   +1 more source

Porcine endogenous retroviruses (PERVs): adaptation to human cells and attempts to infect small animals and non-human primates.

Annals of transplantation, 2002
J, Denner, V, Specke, J, Schwendemann, S J, Tacke   +3 more
openaire   +1 more source

Generation of neutralising antibodies against porcine endogenous retroviruses (PERVs) [PDF]

Virology, 2011
Antibodies neutralising porcine endogenous retroviruses (PERVs) were induced in different animal species by immunisation with the transmembrane envelope protein p15E. These antibodies recognised epitopes, designated E1, in the fusion peptide proximal region (FPPR) of p15E, and E2 in the membrane proximal external region (MPER).
Joachim Denner, Uwe Fiebig, Reinhard Kurth   +2 more
exaly   +4 more sources

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The origin of porcine endogenous retroviruses (PERVs)

Archives of Virology, 2021
Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and they produce viral particles that are able to infect human cells and therefore pose a special risk for xenotransplantation. In contrast to other pig microorganisms that also pose a risk, such as porcine cytomegalovirus and hepatitis E virus, PERVs cannot be eliminated
Joachim Denner
exaly   +3 more sources

Genome-wide inactivation of porcine endogenous retroviruses (PERVs) [PDF]

Science, 2015
Virally cleansing the pig genome Transplants from pigs could be a solution to a shortage of human organs for transplantation. Unfortunately, porcine endogenous retroviruses (PERVs) are rife in pigs and can be transmitted to humans, risking disease. L. Yang et al.
George Church, John Aach, Dennis Grishin   +2 more
exaly   +5 more sources

Unexpected low expression of porcine endogenous retroviruses (PERVs) in porcine expanded potential stem cells (EPSCs)

Virus Research, 2021
Expanded potential stem cells (EPSCs) have been recently derived from porcine preimplantation embryos (Gao et al., 2019). These cells were shown to express key pluripotency genes, to be genetically stable and differentiate to derivatives of the three germ layers and additionally to trophoblast.
Bjoern Petersen, Monika Nowak-Imialek, Joachim Denner   +2 more
exaly   +3 more sources

Modulation of Porcine Endogenous Retroviruses (PERVs) expression in vitro by shRNA in the presence of cyclosporine A and dexamethasone

Annals of Transplantation, 2012
Despite the fact that the risk of Porcine Endogenous Retroviruses (PERV) infection and propagation in human recipients is extremely low, such an event cannot be completely ruled out, especially in immunosuppressed patients. Therefore, the aim of this study was to analyze the expression of PERVs in vitro in the presence of immunosuppression agents ...
Ewa Nowak, Sabina Gałka, Ilona Anna Bednarek   +2 more
exaly   +4 more sources

Expression of porcine endogenous retroviruses (PERVs) in melanomas of Munich miniature swine (MMS) Troll

Veterinary Microbiology, 2007
Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pig breeds. Since some of them are able to infect human cells, they might represent a risk for xenotransplantation using pig cells or organs. However, the expression and biological role of PERVs in healthy pigs as well as in porcine tumours is largely unknown.
Rüdiger Wanke, Joachim Denner, Nadja Herbach   +2 more
exaly   +4 more sources