Frontiers in Immunology, 2021 Malaria remains one of the most serious health problems in developing countries. The causative agent of malaria, Plasmodium spp., have a complex life cycle involving multiple developmental stages as well as different morphological, biochemical and ...
Maria Andrea Hernández-Castañeda +9 more
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Gasdermins in Innate Host Defense Against Entamoeba histolytica and Other Protozoan Parasites
Frontiers in Immunology, 2022 Gasdermins (GSDMs) are a group of proteins that are cleaved by inflammatory caspases to induce pore formation in the plasma membrane to cause membrane permeabilization and lytic cell death or pyroptosis.
Shanshan Wang +2 more
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A pore-forming protein implements VLR-activated complement cytotoxicity in lamprey [PDF]
Cell Discovery, 2017 AbstractLamprey is a basal vertebrate with a unique adaptive immune system, which uses variable lymphocyte receptors (VLRs) for antigen recognition. Our previous study has shown that lamprey possessed a distinctive complement pathway activated by VLR.
Wu, Fenfang +7 more
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Characterization of a leukocidin identified in Staphylococcus pseudintermedius. [PDF]
PLoS ONE, 2018 Bacterial infections from Staphylococcus pseudintermedius are the most common cause of skin infections (pyoderma) affecting dogs. Two component pore-forming leukocidins are a family of potent toxins secreted by staphylococci and consist of S (slow) and F
Mohamed A Abouelkhair +4 more
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Cytotoxic Activities of Leptospira interrogans Hemolysin SphH as a Pore-Forming Protein on Mammalian Cells [PDF]
Infection and Immunity, 2002 ABSTRACT Leptospirosis is a spirochetal zoonosis that causes an acute febrile systemic illness in humans. Leptospira sp. hemolysins have been shown to be virulence factors for the pathogenesis of leptospirosis. Previously, we cloned a hemolysin SphH of Leptospira interrogans serovar
Seoung Hoon, Lee +3 more
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Frontiers in Cellular and Infection Microbiology, 2020 Pore-forming proteins (PFPs) are a group of functionally versatile molecules distributed in all domains of life, and several microbial pathogens notably use members of this class of proteins as cytotoxic effectors.
Nicia Diaz +10 more
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Synthesized Geopolymers Adsorb Bacterial Proteins, Toxins, and Cells
Frontiers in Bioengineering and Biotechnology, 2020 Pore-forming and hemolytic toxins are bacterial cytotoxic proteins required for virulence in many pathogens, including staphylococci and streptococci, and are notably associated with clinical manifestations of disease.
John Popovich +10 more
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Properties of a purified pore-forming protein (perforin 1) isolated from H-2-restricted cytotoxic T cell granules. [PDF]
The Journal of experimental medicine, 1986 Histocompatibility-restricted cytotoxic T lymphocytes produce circular lesions on target cell membranes. The pore-forming protein (PFP or perforin 1) that forms these membrane lesions has been purified from lymphocytes. At 37 degrees C, in the presence of Ca2+, this protein polymerizes into a supramolecular tubular complex of Mr greater than 10(6) that
J D, Young, E R, Podack, Z A, Cohn
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Novel Role for Animal Innate Immune Molecules: Enterotoxic Activity of a Snail Egg MACPF-Toxin
Frontiers in Immunology, 2020 Gastropod Molluscs rely exclusively on the innate immune system to protect from pathogens, defending their embryos through maternally transferred effectors. In this regard, Pomacea snail eggs, in addition to immune defenses, have evolved the perivitellin-
Matías L. Giglio +7 more
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Correlation between in vitro cytotoxicity and in vivo lethal activity in mice of epsilon toxin mutants from Clostridium perfringens. [PDF]
PLoS ONE, 2014 Epsilon toxin (Etx) from Clostridium perfringens is a pore-forming protein with a lethal effect on livestock, producing severe enterotoxemia characterized by general edema and neurological alterations.
Jonatan Dorca-Arévalo +5 more
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