Results 161 to 170 of about 25,125 (214)

Polyphenol-Mediated Peptide Assembly Modulates Melittin Toxicity: A Structure-Activity Strategy for Neutralizing the Interface Affinity of Pore-Forming Toxins to Cell Membranes. [PDF]

ACS Appl Mater Interfaces
Han H, Palchak JC, Pinc JR, Nguyen M, Atchley KA, Darrell DJ, Kim ES, Lee PH, Schleck MC, Cornell AR, Buselmeier JE, Bacon KM, Zang K, Burpeau N, Gabriel JM, Anderson CA, Burpo FJ, Fallot LB, Yuk SF, Limbocker R.   +19 more
europepmc   +1 more source

Spherical Skin Model: Stratified Co‐Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening

Advanced Healthcare Materials, EarlyView.
Models of the human skin must combine the relevant biological contents and suitable biomaterials with the correct spatial organization. Performing compound screening on such in vitro models also requires fast and reproducible production methods of the models.
Elisa Lenzi, Nadia Vertti‐Quintero, Julien Husson, Anne‐Laure Bulteau, Carine Nizard, Karl Pays, Sébastien Sart, Charles N. Baroud   +7 more
wiley   +1 more source

Ionic Mechanisms of Two-Pore Channel Regulation of Vesicle Trafficking. [PDF]

Cells
Zhang H, Zhu MX.
europepmc   +1 more source

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu, Lina Guan, Baihetiya Tayier, Chen Yuan, Shangke Chen, Qi Shi, Yuming Mu   +6 more
wiley   +1 more source

AX-2: A Promising Non-Hemolytic Protein of <i>Bacillus thuringiensis</i> with Potent Selective Cytotoxicity Against Breast Cancer Cells. [PDF]

Molecules
Cruz-Nolasco A, Peña-Rico MA, Estrada-Escobedo SJ, Ortela-Gregorio AA, Juarez-Arellano EA, Vázquez-Victorio G, Martinez-Ramirez AS, Sagrillo MR, Santos RCV, Camacho L, Nieto-Velázquez NG, Navarro-Mtz AK.   +11 more
europepmc   +1 more source

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

Plasticity of the cytotoxic Nep1-like protein enables promiscuity in binding to its lipid receptor glycosylinositol phosphorylceramides. [PDF]

Sci Adv
Kalanj NŽ, Prešern A, Naumoska K, Snoj T, Aupič J, Glavnik V, Albreht A, Mally M, Derganc J, Greimel P, Magistrato A, Anderluh G.   +11 more
europepmc   +1 more source

Enhancing Magnetic Hyperthermia at the Cell Membrane by Anchoring 92R‐Functionalized Magnetic Nanoparticles to Low‐Endocytic CCR9 Surface Receptors

Advanced Healthcare Materials, EarlyView.
We present a strategy to enhance magnetic hyperthermia therapy by modulating nanoparticle–cell interactions. Antibody‐functionalized magnetic nanoparticles targeting the low‐internalizing CCR9 receptor enable spatially controlled membrane anchoring, reducing aggregation and maximizing heat generation under alternating magnetic fields.
David Egea‐Benavente, Isabel Corraliza‐Gorjón, Thomas S. van Zanten, María del Puerto Morales, Leonor Kremer, Domingo F. Barber   +5 more
wiley   +1 more source

The <i>Saccharomyces</i> killer toxin K62 is a protein of the aerolysin family. [PDF]

mBio
Creagh JW, Rolfsmeier M, Evans KJ, Bizarria R, Reetz DC, Badigian TJ, Fredericks LR, Hasenoehrl AM, Brown AP, Graves BM, Alexander CK, Rodrigues A, Stoffregen EP, Patel JS, Ytreberg FM, Rowley PA.   +15 more
europepmc   +1 more source

Effective Penetration of the Oxidized Keratin‐Rebonding Materials Into Hair Shafts Based on Charge Conversion

Advanced Healthcare Materials, EarlyView.
We have developed a smart hair‐repair ingredient based on β‐carboxylic acid amide that undergoes negative‐to‐positive charge conversion under mildly acidic conditions. The initial negative charge facilitates deep penetration into the hair fiber, while the subsequent positive charge enables re‐bonding with sulfonate groups in damaged hair keratin.
Sunyoung Kang, Serena Serin Park, Sugyeong Jeong, Seoyeon Kyung, Minjae Kim, Seok Kyun Yun, Hyun‐Na Kim, Seunghyun Kang, Yan Lee   +8 more
wiley   +1 more source