Results 171 to 180 of about 26,447 (213)

"Zombie virus" like pyroptosis: Extracellular vesicles spread pyroptosis by transferring functional N-GSDMD pore. [PDF]

J Transl Int Med
Zhang Y, Jin S, Tian Y, Qi J.
europepmc   +1 more source

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

Gasdermins in neurodegeneration: emerging mechanisms and therapeutic targets. [PDF]

Cell Death Dis
Chen S, Zhang J, Chen X, Lai Z, Zhao Z, Wang SB.   +5 more
europepmc   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Recombinant HALT-1 induces mitochondrial-associated apoptotic mechanism in HeLa cells. [PDF]

Sci Rep
Loo LW, Hwang JS.
europepmc   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

The molecular mechanisms of pyroptosis and its implications in tumor immunotherapy. [PDF]

Mol Cancer
Chen G, Zhang Z, Chong W, Qiu G, Li Z, Yang S, Pan X, Ma T, Lian G, Wang X, Li L, Tian F, Jing C.   +12 more
europepmc   +1 more source

Cnidarian toxins: omics approaches and recombinant proteins. [PDF]

J Venom Anim Toxins Incl Trop Dis
Vega-Tamayo JE, Alcantar-Orozco EJ, Mendoza-Ramírez RA, Silva-Díaz LG, Aguilar-Salazar JA, Salvador-Aguilar DH, Rojas-Molina A.   +6 more
europepmc   +1 more source

Pathogenic Mechanisms of V. vulnificus and Its Role in the Development of Sepsis. [PDF]

Microbiologyopen
Yu Z, Zhu X, Tang S, Yang S, Li J, Luo L, Tan Y, Yin J.   +7 more
europepmc   +1 more source

Pyroptosis-induced tissue damage in kidney disease. [PDF]

Ren Fail
Zhang Z, Li X, Han Y, Zhang M.
europepmc   +1 more source