Results 191 to 200 of about 26,447 (213)

The Ninth Component of Complement and the Pore-Forming Protein (Perforin 1) from Cytotoxic T Cells: Structural, Immunological, and Functional Similarities

Science, 1986
The ninth component of complement (C9) and the pore-forming protein (PFP or perforin) from cytotoxic T lymphocytes polymerize to tubular lesions having an internal diameter of 100 Å and 160 Å, respectively, when bound to lipid bilayers.
J D, Young, Z A, Cohn, E R, Podack
openaire   +2 more sources

IL-2 and IL-6 synergize to augment the pore-forming protein gene expression and cytotoxic potential of human peripheral blood T cells.

The Journal of Immunology, 1990
Abstract Our previous studies have demonstrated that high dose IL-2 (1000 U/ml) alone can induce human peripheral blood T cell pore-forming protein (PFP) mRNA expression and cytotoxic potential. We now report that the levels of IL-2 needed to induce these effects in T cells can be significantly reduced in the presence of IL-6.
M J, Smyth, J R, Ortaldo, W, Bere, H, Yagita, K, Okumura, H A, Young   +5 more
openaire   +2 more sources

Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore‐forming protein, perforin, and the serine protease, granzyme B

Australian and New Zealand Journal of Medicine, 1995
Abstract:Cytotoxic lymphocytes (CL) comprise two effector cell populations with the ability to eliminate unwanted or harmful cells. Cytotoxic T cells (CTLs) demonstrate both an exquisite specificity and memory in recognising target cell oligopeptides presented within the groove of major histocompatibility complex class I antigens.
openaire   +2 more sources

Effects of heparin and other acid mucopolysaccharides on the activity of a cytolytic pore-forming protein (perforin) from cytotoxic T-lymphocytes.

Journal of biochemistry, 1988
A cytolytic protein (perforin) was rapidly purified from a cell line of mouse cytotoxic T-lymphocytes (CTL) by DEAE-cellulose, heparin-Sepharose, and phenyl-Sepharose chromatographies. The purified perforin was activated by heparin, the half maximal concentration being 3-10 ng/ml, depending on the calcium concentration.
S, Ishiura, H, Koizumi, T, Tsukahara, H, Sugita   +3 more
openaire   +1 more source

Effects of Heparin and Other Acid Mucopolysaccharides on the Activity of a Cytolytic Pore-Forming Protein (Perforin) from Cytotoxic T-Lymphocytes1

The Journal of Biochemistry, 1988
Shoichi Ishiura, Hirotaka Koizumi, Toshifumi Tsukahara, Hideo Sugita   +3 more
openaire   +1 more source

Pore-forming proteins: From defense factors to endogenous executors of cell death

Chemistry and Physics of Lipids, 2021
Uris Ros
exaly  

Pore-Forming Proteins: From Pore Assembly to Structure by Quantitative Single-Molecule Imaging

International Journal of Molecular Sciences, 2023
Katia Cosentino, Eleonora Germana Margheritis   +1 more
exaly  

Pore-forming proteins as drivers of membrane permeabilization in cell death pathways

Nature Reviews Molecular Cell Biology, 2022
Geert Bultynck, Peter Vandenabeele, Savvas Savvides   +2 more
exaly  

Branching out the aerolysin, ETX/MTX-2 and Toxin_10 family of pore forming proteins

Journal of Invertebrate Pathology, 2021
Michelle Dunstone, Bradley Spicer
exaly  

Prediction of Transmembrane Regions, Cholesterol, and Ganglioside Binding Sites in Amyloid-Forming Proteins Indicate Potential for Amyloid Pore Formation

Frontiers in Molecular Neuroscience, 2021
Marjana Novic, Katja Venko, Eva Žerovnik   +2 more
exaly