Results 171 to 180 of about 25,125 (214)

Identification of receptor-binding domains of Bacteroidales antibacterial pore-forming toxins. [PDF]

J Biol Chem
Borgini S, Pasveer E, Petre C, Iorga BI, Vertommen D, Remaut H, Collet JF, Lauber F.   +7 more
europepmc   +1 more source

High‐Throughput Generation of Tumor Spheroids via Droplet Microfluidics for siRNA‐Loaded Nanomedicine Assessment

Advanced Healthcare Materials, EarlyView.
A droplet microfluidic platform is employed to enable high‐throughput, uniform tumor spheroid generation for evaluating siRNA‐loaded nanomedicines at the protein level. As a proof of concept, breast (MCF‐7) and brain (U87 MG) cancer cell lines are investigated using this platform, revealing penetration profiles and therapeutic responses between the two
Ling Liu, Guoying Wang, Yang Zhang, Bingyang Shi, Ming Li   +4 more
wiley   +1 more source

Stepwise assembly of α-hemolysin from intermediates to the mature pore in native erythrocytes. [PDF]

J Cell Biol
Chatterjee A, Roy A, Das PP, Chakraborty D, Ghoshal B, Jhunjhunwala S, Dutta S.   +6 more
europepmc   +1 more source

Doxorubicin‐Loaded Metal–Organic Framework for Ferroptosis‐Enhanced Chemotherapy Through Sustained Zn Release and Glutathione Peroxidase Downregulation

Advanced Healthcare Materials, EarlyView.
A robust zinc‐based metal–organic framework (ZnMOF) enables dual functions of doxorubicin delivery and sustained Zn2+ release to trigger ferroptosis‐enhnaced chemotherapy. DOX@ZnMOF effectively depletes intracellular glutathione, suppresses GPX4, and elevates reactive oxygen species, leading to efficient oxidative DNA damage and apoptosis.
Xin Ma, Chenghua Deng, Chaoyu Wang, Langston Tilman, Jinhong Li, Wenbin Lin   +5 more
wiley   +1 more source

SARS-CoV-2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting. [PDF]

Proc Natl Acad Sci U S A
Zhang Y, Silvestre-Roig C, Fu H, Alimohamadi H, Mandal T, Chen JW, Luo EW, Anda J, Linard Matos AL, Richter M, Mennella A, Lee H, Chan LC, Wang Y, Wang N, Wang H, Wang X, Lee CK, Ghosh S, Matsui T, Weiss TM, Guo T, Zhang M, Li D, Wolfgang MC, Hagan RS, Li MMH, Gunzer M, Sickmann A, Frasca L, Yeaman MR, Lande R, Cui Q, Soehnlein O, Wong GCL.   +34 more
europepmc   +1 more source

Novel amino acid residues in listerolysin O drive phagosome escape and pathogenicity in <i>Listeria monocytogenes</i>. [PDF]

Virulence
Xia J, Feng Y, Xu J, Deng S, Chen M, Han Y, Wang J, Sun J, Rantsiou K, Cocolin LS, Song H, Cheng C.   +11 more
europepmc   +1 more source

Coral Venom and Toxins as Protection Against Crown-of-Thorns Sea Star Attack. [PDF]

Mol Ecol
Gorman LM, Huffmyer AS, Byrne M, Mills SC, Putnam HM.   +4 more
europepmc   +1 more source

Gasdermins: multifunctional effectors of membrane permeabilization across cellular compartments. [PDF]

FEBS J
Margheritis E, Gehle N, Cosentino K.
europepmc   +1 more source

Integrating Metal-Organic Frameworks with Antimicrobial Peptides: Advances and Challenges in Antibacterial Therapeutics. [PDF]

ACS Omega
Sun Y, Zhong H, Wang Y, Zhang X, Cai H, Chen J.   +5 more
europepmc   +1 more source

Expanding the amyloid landscape: structural plasticity of antimicrobial peptides

Landau M, Ragonis-Bachar P, Strati F, Gustavsson E, Khokhlov A, Barnea E, Rayan B, Upcher A.   +7 more
europepmc   +1 more source