Constitutive expression of pore-forming protein in peripheral blood gamma/delta T cells: implication for their cytotoxic role in vivo. [PDF]
The Journal of experimental medicine, 1990 The cytotoxic activity and pore-forming protein (PFP) expression of human peripheral blood (PB) gamma/delta T cells were examined. Fresh gamma/delta T cells isolated from PB lymphocytes by fluorescence-activated cell sorting exhibited a substantial natural killer-like cytotoxic activity against K562 target cells and had a high cytotoxic potential ...
M, Nakata +6 more
openaire +2 more sources
Evaluating cytotoxic effects of recombinant fragaceatoxin C pore forming toxin against AML cell lines [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Current therapeutic strategies for cancer are associated with side effects and lack of specificity in treatments. Biological therapies including monoclonal antibodies and immune effectors have been the subject of multiple research projects.
Mahnaz Azadpour +6 more
doaj +1 more source
The gasdermins: a pore-forming protein family expressed in the epidermis
Frontiers in Immunology, 2023 Gasdermins comprise a family of pore-forming proteins, which play critical roles in (auto)inflammatory diseases and cancer. They are expressed as self-inhibited precursor proteins consisting of an aminoterminal cytotoxic effector domain (NT-GSDM) and a ...
Marta Slaufova +5 more
doaj +1 more source
Noncytotoxic functions of killer cell granzymes in viral infections.
PLoS Pathogens, 2021 Cytotoxic lymphocytes produce granules armed with a set of 5 serine proteases (granzymes (Gzms)), which, together with the pore-forming protein (perforin), serve as a major defense against viral infections in humans.
Lisanne C de Jong +3 more
doaj +1 more source
Cells, 2022 Claudins are a family of integral membrane proteins that enable epithelial cell/cell interactions by localizing to and driving the formation of tight junctions.
Chinemerem P. Ogbu +2 more
doaj +1 more source
Cytotoxic and apoptosis-inducing effects of wildtype and mutated Hydra actinoporin-like toxin 1 (HALT-1) on various cancer cell lines [PDF]
PeerJ, 2019 Background Hydra actinoporin like toxin -1 (HALT-1), is a small 18.5 kDa pore forming toxin derived from Hydra magnipapillata which has been shown to elicit strong haemolytic and cytolytic activity when in contact with cell membranes.
Teng Jia Ng +6 more
doaj +2 more sources
Perforins Expression by Cutaneous Gamma Delta T Cells
Frontiers in Immunology, 2020 Gamma delta (GD) T cells are an unconventional T cell type present in both the epidermis and the dermis of human skin. They are critical to regulating skin inflammation, wound healing, and anti-microbial defense.
Katelyn O'Neill +3 more
doaj +1 more source
Solid tumor-targeted infiltrating cytotoxic T lymphocytes retained by a superantigen fusion protein. [PDF]
PLoS ONE, 2011 Successful immune-mediated regression of solid tumors is difficult because of the small number of cytotoxic T lymphocytes (CTLs) that were traffic to the tumor site.
Jialin Sun +6 more
doaj +1 more source
A Novel Strategy for Enhance Potentiation of Meglumine antimoniate against Leishmania major In Vitro
Iranian Journal of Parasitology, 2019 Background: We aimed to design a different method of drug delivery for increased transfer of the choice drug (meglumine antimoniate) within the host cells.
Farzaneh MIRZAEI +4 more
doaj +1 more source
Staphylococcus aureus panton-valentine leukocidin is a very potent cytotoxic factor for human neutrophils. [PDF]
PLoS Pathogens, 2010 The role of the pore-forming Staphylococcus aureus toxin Panton-Valentine leukocidin (PVL) in severe necrotizing diseases is debated due to conflicting data from epidemiological studies of community-associated methicillin-resistant S.
Bettina Löffler +9 more
doaj +1 more source