Acute Intermittent Porphyria in a Man with Dual Enzyme Deficiencies [PDF]
Case Reports in Genetics, 2020 Porphyrias are a heterogeneous group of metabolic disorders that result from the altered activity of specific enzymes of the heme biosynthetic pathway and are characterized by accumulation of pathway intermediates.
G. N. Cerbino +6 more
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Protective Action of Antioxidants on Hepatic Damage Induced by Griseofulvin [PDF]
The Scientific World Journal, 2014 Erythropoietic protoporphyria (EPP) is a disease associated with ferrochelatase deficiency and characterized by the accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin.
M. del C. Martinez +3 more
doaj +3 more sources
Clinical, biochemical, and genetic characterization of acute hepatic porphyrias in a cohort of Argentine patients [PDF]
Molecular Genetics & Genomic Medicine, 2021 Background Acute Hepatic Porphyrias (AHPs) are characterized by an acute neuroabdominal syndrome including both neuropsychiatric symptoms and neurodegenerative changes.
María del Carmen Martinez +5 more
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Photosensitization of a subcutaneous tumour by the natural anthraquinone parietin and blue light [PDF]
Scientific Reports, 2021 Photodynamic therapy (PDT) is an anticancer treatment involving administration of a tumour-localizing photosensitizer, followed by activation by light of a suitable wavelength. In previous work, we showed that the natural anthraquinone (AQ) Parietin (PTN)
María Laura Mugas +9 more
doaj +2 more sources
An Improved Technique for Genotyping the ABCB1 Gene Variant of Exon 21 [PDF]
Methods and Protocols, 2023 The Multidrug Resistance protein (ABCB1, MDR1) is involved in the transport of xenobiotics and antiretroviral drugs. Some variants of the ABCB1 gene are of clinical importance; among them, exon 12 (c.1236C>T, rs1128503), 21 (c.2677G>T/A, rs2032582), and ...
Johanna Romina Zuccoli +5 more
doaj +2 more sources
Novel meso-substituted porphyrin derivatives and its potential use in photodynamic therapy of cancer [PDF]
BMC Cancer, 2021 Background Photodynamic therapy (PDT) is an anticancer treatment that utilizes the interaction of light and a photosensitiser (PS), promoting tumour cell death mediated by generation of reactive oxygen species.
Pablo Vallecorsa +8 more
doaj +2 more sources
An increase in O-GlcNAcylation of Sp1 down-regulates the gene expression of pi class glutathione S-transferase in diabetic mice [PDF]
Biochemistry and Biophysics Reports, 2021 Oxidative stress is a key factor contributing to the development of diabetes complications. Glutathione S-transferases (GSTs) protect against products of oxidative stress by conjugating glutathione to electrophilic substrates, producing compounds that ...
Leda María Oliveri +2 more
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Acute intermittent porphyria in Argentina: an update. [PDF]
Biomed Res Int, 2015 Porphyrias are a group of metabolic diseases that arise from deficiencies in the heme biosynthetic pathway. A partial deficiency in hydroxymethylbilane synthase (HMBS) produces a hepatic disorder named Acute Intermittent Porphyria (AIP); the acute porphyria is more frequent in Argentina.
Cerbino GN +6 more
europepmc +2 more sources
Experimental protoporphyria: effect of bile acids on liver damage induced by griseofulvin. [PDF]
Biomed Res Int, 2015 The effect of bile acids administration to an experimental mice model of Protoporphyria produced by griseofulvin (Gris) was investigated. The aim was to assess whether porphyrin excretion could be accelerated by bile acids treatment in an attempt to diminish liver damage induced by Gris.
Martinez Mdel C +5 more
europepmc +2 more sources
The Impact of Low-Level Benzalkonium Chloride Exposure on Staphylococcus spp. Strains and Control by Photoinactivation [PDF]
Antibiotics, 2023 Exposure of bacteria to low concentrations of biocides can facilitate horizontal gene transfer, which may lead to bacterial adaptive responses and resistance to antimicrobial agents.
Erika C. R. Bonsaglia +6 more
doaj +2 more sources