Results 51 to 60 of about 33,593 (191)

Innovaatioprosessin ja tietojärjestelmien väliset rajapinnat hyvinvointialalla

Finnish Journal of eHealth and eWelfare, 2009
Tämän tutkimuksen tavoitteena on selvittää tietojärjestelmien ja innovaatioprosessien välisiä rajapintoja sekä kuvata innovaatioprosessia tukevia tietojärjestelmäratkaisuja.
Outi Seppä, Lauri Salmivalli
doaj  

ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS

Медицинская иммунология, 2014
. We investigated immunogenic properties of vaccine constructs based on lipid-saponin tubular immunostimulating  complexes  (TI-complexes),  and  an  individual  antigen,  i.e.,  monomeric  and  trimeric forms of porin isolated from Yersinia ...
A. V. Tsybulsky, A. M. Popov, O. Yu. Portnyagina, A. A. Artyukov, N. M. Sanina, A. N. Mazeyka, E. Y. Kostetsky   +6 more
doaj   +1 more source

Chromosome‐scale genome assembly of the South American fruit fly, Anastrepha fraterculus sp.1

Insect Science, EarlyView.
Anastrepha fraterculus sp. 1 is a major fruit fly pest in Argentina, currently controlled through chemical treatments and traps. This study aims to enhance the genomic understanding of this species to support the development of sterile insect technique as well as the use of innovative technologies.
Máximo Rivarola, Claudia A. Conte, Pierre Berube, Shu‐Huang Chen, M. Cecilia Giardini, Alejandra C. Scannapieco, Fabián H. Milla, María C. Soria, Romina M. Russo, Juan P. Wulff, Haig H. Djambazian, Rolando R. Pomar, Alfred M. Handler, Kostas Bourtzis, Ioannis Ragoussis, Silvia B. Lanzavecchia   +15 more
wiley   +1 more source

Maisema värillisenä kaupunkipienoismallina

Ennen ja Nyt: Historian Tietosanomat, 2022
Tämä artikkeli käsittelee kaupunkihistoriallisten pienoismallien värillisyyttä. Artikkelissa tarkastelen neljää alueellisen vastuumuseon perusnäyttelyssä esillä olevaa kaupunkipienoismallia.
Susanna Siro
doaj   +1 more source

The ribosome‐associated complex regulates cytosolic translation upon mitoprotein‐induced stress

The FEBS Journal, EarlyView.
Defects in mitochondrial protein import trigger a stress response. The contribution of translation regulation to such a response is only partially understood. We demonstrate that the deletion of mitochondrial surface proteins (TOM70/TOM71) leads to defects in mitochondrial biogenesis and slow growth.
Jiaxin Qian, Annika Nutz, Katja Hansen, Lea Bertgen, Mirita Franz‐Wachtel, Boris Macek, Johannes M. Herrmann, Doron Rapaport   +7 more
wiley   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Large-scale prediction of outer-membrane multiheme cytochromes uncovers hidden diversity of electroactive bacteria and underlying pathways

Frontiers in Microbiology
Multi-heme cytochromes (MHCs), together with accessory proteins like porins and periplasmic cytochromes, enable microbes to transport electrons between the cytoplasmic membrane and extracellular substrates (e.g., minerals, electrodes, other cells ...
Arkadiy I. Garber, Kenneth H. Nealson, Nancy Merino   +2 more
doaj   +1 more source

Anti‐cancer drugs targeting the NADH‐binding site of VDAC rewire channel electrophysiology and partially suppress cation selectivity

The FEBS Journal, EarlyView.
VA molecules alter VDAC1 gating by increasing anion flow and reducing cation permeability. In cancer cells, which rely on ER‐mitochondria Ca2+ transfer and overexpress VDAC1, this imbalance triggers bioenergetic stress, ROS buildup, and mitochondrial collapse, leading to cell death.
Stefano Conti‐Nibali, Giuseppe Battiato, Salvatore Antonio Maria Cubisino, Cristina Arrigoni, Marco Lolicato, Simona Reina, Vito De Pinto   +6 more
wiley   +1 more source

Three Closely Related Spodoptera Species Similarly Affect Gene Expression and Phytohormone Levels but Differentially Induce Volatile Emissions in Maize

Plant, Cell &Environment, EarlyView.
ABSTRACT Plants can perceive specific elicitors in the oral secretions (OS) of herbivorous insects and respond by increasing their defences. Whether plants can discriminate among similar herbivorous insect species and differentially modulate their defence responses against them is largely unknown.
Wenfeng Ye, Sara Leite Dias, Marine Mamin, Carla C. M. Arce, Ted C. J. Turlings   +4 more
wiley   +1 more source

Antibiotic Transport through Porins [PDF]

Biophysical Journal, 2014
The emergence and dissemination of coordinated resistance mechanism (MDR) underline the importance to understand the rate limiting steps in antibiotic action. Here OmpF porin from E. coli is used as an example to demonstrate what limits the penetration of carbapenems.
Bajaj Harsha, CECCARELLI, MATTEO, Mahendran Kozhinjampara Radhakrishnan, James Chloe E., Pages Jean Marie, Winterhalter Mathias   +5 more
openaire   +2 more sources