Results 71 to 80 of about 33,593 (191)

Atomic‐Precision Symmetry Breaking in Bi‐O‐Ti Sites Enables ROS Generation for Bactericidal and Osteosarcoma Therapy

Rare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT Photocatalytic therapy, which generates reactive oxygen species (ROS) upon light irradiation, has garnered significant interest for antibacterial and anticancer applications. This study establishes a doping‐engineered photocatalytic platform for antibacterial activity and precision osteosarcoma therapy by atomically constructing asymmetric Bi ...
Jun Gu, Haitao Yuan, Bo Chu, Tianqi Wang, Jin Fan, Xuan Sun, Feng Shi, Qinqin Liu, Xiaojun Feng   +8 more
wiley   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, Volume 22, Issue 16, 17 March 2026.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Phospholipid Scramblase Activity of VDAC Dimers: New Implications for Cell Death, Autophagy and Ageing

Biomolecules
Voltage-dependent anion channels (VDACs) are important proteins of the outer mitochondrial membrane (OMM). Their beta-barrel structure allows for efficient metabolite exchange between the cytosol and mitochondria.
Patrick Rockenfeller
doaj   +1 more source

Bioengineered Bacterial Vesicles and Biomimetic Hybrids Eliminate Biofilms and Balance the Gut Microbiome

Small, Volume 22, Issue 16, 17 March 2026.
Biomimetic nanocarriers based on liposomes and Myxobacteria outer‐membrane vesicles (OMVs) are effective antibiotic delivery systems. Hybrids have a higher drug loading and can target intracellular pathogens, while OMVs evade immune clearance. Biomimetic nanoantibiotics effectively eliminate the biofilms of Gram‐negative bacteria. Besides, Myxobacteria
Leila Pourtalebi Jahromi, Benedikt Kronast, Jennifer Munkert, Lorenzo Sana, Marcus Koch, Heike Danzer, Sirka Dormeyer, Shuhan Jiang, Fabian Herrmann, Matthias Weiler, Anna Kashkanova, Vahid Sandoghdar, Mario M. Zaiss, Gregor Fuhrmann   +13 more
wiley   +1 more source

Nanopores: maltoporin channel as a sensor for maltodextrin and lambda-phage

Journal of Nanobiotechnology, 2005
Background To harvest nutrition from the outside bacteria e.g. E. coli developed in the outer cell wall a number of sophisticated channels called porins. One of them, maltoporin, is a passive specific channel for the maltodextrin uptake. This channel was
Fournier D, Danelon C, Charbit A, Orlik F, Berkane E, Benz R, Winterhalter M   +6 more
doaj   +1 more source

A Comprehensive Review of the Multitarget Effects of Subinhibitory Concentrations of Essential Oils Against Salmonella

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 2, March 2026.
ABSTRACT Essential oils (EOs) exhibit antimicrobial activity against foodborne pathogens due to their chemical composition. This review investigates the mechanisms of action of EOs at subinhibitory concentrations against Salmonella strains. Even at subinhibitory concentrations, EOs induce cellular stress and modulate bacterial metabolism. EOs interfere
Carolina Ramos, Yhan S. Mutz, Leticia Tessaro, Bruno Dutra da Silva, Marciane Magnani, Carlos Adam Conte‐Junior   +5 more
wiley   +1 more source

Antimicrobial Susceptibility Pattern and Mutations of Outer Membrane Porin in Clinical Isolates of Klebsiella pneumoniae

مجله علمی دانشگاه علوم پزشکی کردستان, 2022
Background and Aim: Klebsiella pneumoniae is one of the most common causes of community-acquired and nosocomial infections and has acquired numerous resistance mechanisms over time.
Maryam Bayramnezhad, Maryam Ghane, Elham Asadi   +2 more
doaj  

Protein Language Model‐Driven Optimisation of Antimicrobial Peptide Pth‐Ca1 Against Pectobacterium brasiliense Using ESMFold‐Predicted Structures and the ESM‐3 Model

Molecular Plant Pathology, Volume 27, Issue 3, March 2026.
AI (ESM‐3/ESMFold) was used to design a potent antimicrobial peptide, Design_1867, derived from a plant defensin (Pth‐Ca1). Design_1867 exhibits enhanced antibacterial activity by forming barrel‐stave pores in bacterial membranes and binding genomic DNA, effectively protecting plants without significant cytotoxicity.
Linhui Song, Ge Zhang, Mengying Hua, Jingna Yuan, Jian Wu, Huan Wang, Fei Yan, Jiejun Peng   +7 more
wiley   +1 more source

Antimicrobial Resistance and Mortality in Carbapenem-Resistant Pseudomonas aeruginosa Infections in Southern Thailand

Antibiotics
Background/Objectives: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is an important pathogen associated with high mortality and treatment failure rates.
Parichart Chotimakorn, Sutthiporn Pattharachayakul, Yongyut Lertsrisatit, Wichai Santimaleeworagun, Pimpimon Tansakul, Mingkwan Yingkajorn, Sureerat Chelae, Rattanaruji Pomwised, Arnon Chukamnerd, Rosesathorn Soontarach, Sarunyou Chusri   +10 more
doaj   +1 more source

The small yeast GTPase Rho5 requires specific mitochondrial outer membrane proteins for translocation under oxidative stress and interacts with the VDAC Por1

European Journal of Cell Biology
Yeast Rho5 is a small GTPase which mediates the response to nutrient and oxidative stress, and triggers mitophagy and apoptosis. We here studied the rapid translocation of a GFP-tagged Rho5 to mitochondria under such stress conditions by live-cell ...
Linnet Bischof, Franziska Schweitzer, Hans-Peter Schmitz, Jürgen J. Heinisch   +3 more
doaj   +1 more source