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Positive Selection in Prion Protein
Journal of Molecular Evolution, 2009The prion diseases, such as Creutzfeldt-Jakob disease of humans and bovine spongiform encephalopathy, involve the aberrant metabolism and accumulation of prion protein PrP. There are three contradictory hypotheses about evolution of prion protein gene PRNP.
Marko, Premzl, Vera, Gamulin
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Genomic insights into positive selection
Trends in Genetics, 2006The traditional way of identifying targets of adaptive evolution has been to study a few loci that one hypothesizes a priori to have been under selection. This approach is complicated because of the confounding effects that population demographic history and selection have on patterns of DNA sequence variation.
Shameek, Biswas, Joshua M, Akey
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Current Opinion in Immunology, 1995
In the past year, significant technical developments have provided the opportunity to investigate the more mechanistic features of positive selection. Major progress has been made in determining the structure and function of the early pre-T cell receptor, in defining cell types that mediate positive selection, and in analyzing the contribution of MHC ...
B J, Fowlkes, E, Schweighoffer
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In the past year, significant technical developments have provided the opportunity to investigate the more mechanistic features of positive selection. Major progress has been made in determining the structure and function of the early pre-T cell receptor, in defining cell types that mediate positive selection, and in analyzing the contribution of MHC ...
B J, Fowlkes, E, Schweighoffer
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Permissive recognition during positive selection
European Journal of Immunology, 1996AbstractIn the periphery αβ T lymphocytes recognize antigens in conjunction with major histocompatibility complex (MHC) molecules. In the thymus immature T cells are positively selected on MHC molecules in the apparent absence of cognate peptides. Thus, at different developmental stages a T cell responds to different epitopes, yet uses the identical αβ
T J, Pawlowski +4 more
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Positive and Negative Thymocyte Selection
Critical Reviews™ in Immunology, 1998T cells differentiate from CD4-CD8- (DN) precursor to mature CD4+ or CD8+ (SP) thymocytes through the CD4+CD8+ (DP) stage. Immature thymocytes express pre-TCR complex composed of pT alpha and TCR beta chains, which plays a role in allelic exclusion of TCR beta and promotion from DN to DP transition.
T, Saito, N, Watanabe
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Immunological outreach through positive selection
Nature Immunology, 2008The American Association of Immunologists sponsors summer fellowships for high school and middle school teachers in the laboratories of its members. New curricula developed through the program are expected to enhance secondary school science education throughout the United States.
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2007
AbstractPositive natural selection, though rare in comparison with negative selection, is the main evolutionary force responsible for adaptive evolutionary change. Using the neutral theory to generate null hypotheses, evolutionary geneticists have developed tests for detecting positive selection.
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AbstractPositive natural selection, though rare in comparison with negative selection, is the main evolutionary force responsible for adaptive evolutionary change. Using the neutral theory to generate null hypotheses, evolutionary geneticists have developed tests for detecting positive selection.
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Positive selection for autoimmunity
Nature Medicine, 2000Negative selection of developing T cells in the thymus is not the only mechanism by which central tolerance to self antigens is acquired. Alternative possibilities are demonstrated in a new model of autoimmune disease (pages 298–305 ).
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2017
<div class="section abstract"> <div class="htmlview paragraph">A driver selected seat position tool has been developed to describe where certain percentages of drivers position horizontally adjustable seats in various workspace arrangements.
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<div class="section abstract"> <div class="htmlview paragraph">A driver selected seat position tool has been developed to describe where certain percentages of drivers position horizontally adjustable seats in various workspace arrangements.
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