Results 251 to 260 of about 9,021,030 (297)
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Science Signaling, 2012
Voltage-gated sodium channels enhance Ca 2+ influx in response to nonself ligands and promote the development of CD4 + T cells.
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Voltage-gated sodium channels enhance Ca 2+ influx in response to nonself ligands and promote the development of CD4 + T cells.
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Raf regulates positive selection
European Journal of Immunology, 1996AbstractT cell development is regulated by extracellular signals that mediate cellular proliferation and differentiation via specific signal transduction pathways. To determine the importance of the mitogen‐activated protein kinase (MAP kinase) pathway in thymocyte development, we analyzed transgenic mice expressing dominant negative Raf (DN Raf) and a
C C, O'Shea +4 more
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Genomic insights into positive selection
Trends in Genetics, 2006The traditional way of identifying targets of adaptive evolution has been to study a few loci that one hypothesizes a priori to have been under selection. This approach is complicated because of the confounding effects that population demographic history and selection have on patterns of DNA sequence variation.
Shameek, Biswas, Joshua M, Akey
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Position estimation of selected targets
Proceedings of IEEE International Conference on Robotics and Automation, 2002Recovering depth and 3D position using known camera motion is useful for solving many problems in robotics such as object manipulation, navigation, and localization. Most existing techniques attempt to solve the general problem by recovering depth across the entire image.
Richard LeGrand, Ren C. Luo
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Positive Selection in Prion Protein
Journal of Molecular Evolution, 2009The prion diseases, such as Creutzfeldt-Jakob disease of humans and bovine spongiform encephalopathy, involve the aberrant metabolism and accumulation of prion protein PrP. There are three contradictory hypotheses about evolution of prion protein gene PRNP.
Marko, Premzl, Vera, Gamulin
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Positive selection in the evolution of cancer
Biological Reviews, 2006We hypothesize that forms of antagonistic coevolution have forged strong links between positive selection at the molecular level and increased cancer risk. By this hypothesis, evolutionary conflict between males and females, mothers and foetuses, hosts and parasites, and other parties with divergent fitness interests has led to rapid evolution of ...
Bernard J, Crespi, Kyle, Summers
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Positive and Negative Thymocyte Selection
Critical Reviews™ in Immunology, 1998T cells differentiate from CD4-CD8- (DN) precursor to mature CD4+ or CD8+ (SP) thymocytes through the CD4+CD8+ (DP) stage. Immature thymocytes express pre-TCR complex composed of pT alpha and TCR beta chains, which plays a role in allelic exclusion of TCR beta and promotion from DN to DP transition.
T, Saito, N, Watanabe
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Current Opinion in Immunology, 1995
In the past year, significant technical developments have provided the opportunity to investigate the more mechanistic features of positive selection. Major progress has been made in determining the structure and function of the early pre-T cell receptor, in defining cell types that mediate positive selection, and in analyzing the contribution of MHC ...
B J, Fowlkes, E, Schweighoffer
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In the past year, significant technical developments have provided the opportunity to investigate the more mechanistic features of positive selection. Major progress has been made in determining the structure and function of the early pre-T cell receptor, in defining cell types that mediate positive selection, and in analyzing the contribution of MHC ...
B J, Fowlkes, E, Schweighoffer
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Positive and negative selection in Basel
Nature Immunology, 2008Harald von Boehmer describes how he used mice transgenic for T cell receptor αβ to identify T cell receptor–dependent cellular selection and lineage commitment as mechanisms responsible for generating an effective and self-tolerant adaptive immune system.
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