Results 31 to 40 of about 1,927,312 (260)

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Paralogues From the Expanded Tlr11 Gene Family in Mudskipper (Boleophthalmus pectinirostris) Are Under Positive Selection and Respond Differently to LPS/Poly(I:C) Challenge

Frontiers in Immunology, 2019
Toll-like receptors (TLRs) are major molecular pattern recognition receptors, which are essential for triggering a series of innate immune responses against invading pathogens by recognizing their evolutionary conserved molecular patterns. The mudskipper,
Heng Tong Qiu, Jorge M. O. Fernandes, Wan Shu Hong, Wan Shu Hong, Hai Xu Wu, Yu Ting Zhang, Sheng Huang, Dong Teng Liu, Hui Yu, Qiong Wang, Xin Xin You, Shi Xi Chen, Shi Xi Chen, Shi Xi Chen   +13 more
doaj   +1 more source

Interplay of Various Evolutionary Modes in Genome Diversification and Adaptive Evolution of the Family Sulfolobaceae

Frontiers in Microbiology, 2021
Sulfolobaceae family, comprising diverse thermoacidophilic and aerobic sulfur-metabolizing Archaea from various geographical locations, offers an ideal opportunity to infer the evolutionary dynamics across the members of this family.
Rachana Banerjee, Narendrakumar M. Chaudhari, Abhishake Lahiri, Abhishake Lahiri, Anupam Gautam, Anupam Gautam, Debaleena Bhowmik, Debaleena Bhowmik, Chitra Dutta, Sujay Chattopadhyay, Daniel H. Huson, Daniel H. Huson, Sandip Paul, Sandip Paul   +13 more
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Identification of Genes under Positive Selection Reveals Differences in Evolutionary Adaptation between Brown-Algal Species

Frontiers in Plant Science, 2017
Brown algae are an important taxonomic group in coastal ecosystems. The model brown algal species Ectocarpus siliculosus and Saccharina japonica are closely related lineages.
Linhong Teng, Xiao Fan, Dong Xu, Xiaowen Zhang, Thomas Mock, Naihao Ye, Naihao Ye   +6 more
doaj   +1 more source

High Levels of Within-Host Variations of Human Papillomavirus 16 E1/E2 Genes in Invasive Cervical Cancer

Frontiers in Microbiology, 2020
Human papillomavirus type 16 (HPV16) is the most common HPV genotype found in invasive cervical cancer (ICC). Recent comprehensive genomics studies of HPV16 have revealed that a large number of minor nucleotide variations in the viral genome are present ...
Yusuke Hirose, Mayuko Yamaguchi-Naka, Mamiko Onuki, Yuri Tenjimbayashi, Nobutaka Tasaka, Toyomi Satoh, Kohsei Tanaka, Kohsei Tanaka, Takashi Iwata, Akihiko Sekizawa, Koji Matsumoto, Iwao Kukimoto   +11 more
doaj   +1 more source

Functional conservation and divergence in plant-specific GRF gene family revealed by sequences and expression analysis

Open Life Sciences, 2022
Unique to plants, growth regulatory factors (GRFs) play important roles in plant growth and reproduction. This study investigated the evolutionary and functional characteristics associated with plant growth. Using genome-wide analysis of 15 plant species,
Meng Lingyan, Li Xiaomeng, Hou Yue, Li Yaxuan, Hu Yingkao   +4 more
doaj   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Comparative Genomics Reveals Accelerated Evolution of Fright Reaction Genes in Ostariophysan Fishes

Frontiers in Genetics, 2019
The ostariophysian fishes are the most species-rich clade in freshwaters. This diversification has been suggested to be associated with the fright reaction presented in most ostariophysians.
Liandong Yang, Haifeng Jiang, Haifeng Jiang, Juan Chen, Juan Chen, Yi Lei, Yi Lei, Ning Sun, Ning Sun, Wenqi Lv, Wenqi Lv, Thomas J. Near, Shunping He, Shunping He, Shunping He   +14 more
doaj   +1 more source

Evidence of hard‐selective sweeps suggests independent adaptation to insecticides in Colorado potato beetle (Coleoptera: Chrysomelidae) populations

Evolutionary Applications, 2022
Pesticide resistance provides one of the best examples of rapid evolution to environmental change. The Colorado potato beetle (CPB) has a long and noteworthy history as a super‐pest due to its ability to repeatedly develop resistance to novel ...
Zachary P. Cohen, Yolanda H. Chen, Russell Groves, Sean D. Schoville   +3 more
doaj   +1 more source