Results 31 to 40 of about 9,021,030 (297)

Soft sweeps III: The signature of positive selection from recurrent mutation [PDF]

, 2006
Polymorphism data can be used to identify loci at which a beneficial allele has recently gone to fixation, given that an accurate description of the signature of selection is available. In the classical model that is used, a favored allele derives from a
Pleuni S. Pennings, Joachim Hermisson, Pennings, Pleuni S., Hermisson, Joachim, Pleuni S Pennings   +4 more
core   +2 more sources

On the logic of positive selection

Immunology, 2006
This is a comment that questions the almost unanimous assumption that the T-cell antigen receptor (TCR) delivers distinctly different signals dependent on the level or duration of occupancy. When the TCR of the thymic precursor (CD4+ CD8+) (referred to here as oT) docks on the major histocompatibility complex-encoded restricting element (referred to
openaire   +3 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

SNP genotyping identifies new signatures of selection in a deep sample of West African Plasmodium falciparum malaria parasites. [PDF]

, 2012
We used a high-density single-nucleotide polymorphism array to genotype 75 Plasmodium falciparum isolates recently collected from Senegal and The Gambia to search for signals of selection in this malaria endemic region.
Bei, Amy K, Conway, David J, Ndiaye, Daouda, Schaffner, Stephen, Neafsey, Daniel E, Wirth, Dyann, Lukens, Amanda, Conway, David J., Park, Daniel J, Volkman, Sarah, Amambua-Ngwa, Alfred, Wirth, Dyann F, Barnes, Kayla G., Schaffner, Stephen F, Lukens, Amanda K, Park, Daniel John, Bei, Amy, Van Tyne, Daria, Volkman, Sarah K, Sene, Papa, Neafsey, Daniel, Barnes, Kayla G   +21 more
core   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes. [PDF]

, 2009
The prevalence of CD36 deficiency in East Asian and African populations suggests that the causal variants are under selection by severe malaria. Previous analysis of data from the International HapMap Project indicated that a CD36 haplotype bearing a ...
Jallow, Muminatou, Palma, Alejandro, Jeffreys, Anna E, Michael J. Griffiths, Fry, Andrew Evan, Teo, Yik Y, Taylor, Terrie E., Kerrin S. Small, Fry, A. E., Fry, Andrew E., Williams, T. N., Diakite, M, Palma, A., Oduro, Abraham R., Newton, C. R., Kwiatkowski, DP, Anna E. Jeffreys, Pinder, M., Jeffreys, AE, Kwadwo A. Koram, Fry, AE, Kwiatkowski, Dominic, Sisay-Joof, Fatou, Williams, Thomas N., Kirk A. Rockett, Clark, Taane G., Wilson, Jonathan, Rockett, KA, Koram, KA, Abraham R. Oduro, Dominic P. Kwiatkowski, Mahamadou Diakite, Yik Y. Teo, Ghansa, A., Jeffreys, A. E., Kwiatkowski, Dominic P., Campino, S, Anita Ghansa, Taane G. Clark, Koram, Kwadwo, Clark, Taane G, Clark, TG, Malcolm E. Molyneux, Molyneux, Malcolm E, Thomas N. Williams, Ghansa, Anita, Green, Angela, Kevin Marsh, Griffiths, Michael J., Small, Kerrin S, Fatou Sisay-Joof, Pinder, M, Taylor, T. E., Clark, T. G., Susana Campino, Auburn, S., Norbert Peshu, Sarah Auburn, Pardis C. Sabeti, Diakite, Mahamadou, Rockett, Kirk A, Sabeti, PC, Rogers, WO, Oduro, Abraham R, Molyneux, Malcolm E., Jallow, M, Marsh, K, Teo, Yik Y., Small, K. S., Campino, S., Rogers, W. O., Green, A., Koram, Kwadwo A., Marsh, Kevin, Pinder, Margaret, Small, Kerrin S., Angela Green, Oduro, AR, Andrew E. Fry, Teo, YY, Teoh, Yin Yoong Jimmy, Kwiatkowski, D. P., Palma, A, Jonathan Wilson, Peshu, N, Alejandro Palma, Williams, TN, Taylor, Terrie E, Griffiths, M. J., Rockett, K. A., Green, A, William O. Rogers, Terrie E. Taylor, Koram, K. A., Sabeti, Pardis C., Sisay-Joof, F, Newton, Charles R., Teo, Y. Y., Molyneux, ME, Rogers, William O, Oduro, A. R., Peshu, N., Rockett, Kirk A., Jeffreys, Anna E., Auburn, Sarah, Diakite, M., Wilson, J., Auburn, S, Koram, Kwadwo A, Griffiths, MJ, Griffiths, Michael J, Newton, Charles R, Muminatou Jallow, Fry, Andrew E, Small, KS, Newton, CR, Jallow, M., Peshu, Norbert, Campino, Susana, Sabeti, Pardis, Sabeti, P. C., Sisay-Joof, F., Williams, Thomas N, Rogers, William O., Taylor, TE, Wilson, J, Charles R. Newton, Ghansa, A, Margaret Pinder, Williams, Thomas, Sabeti, Pardis C, Kwiatkowski, Dominic P   +131 more
core   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Paralogues From the Expanded Tlr11 Gene Family in Mudskipper (Boleophthalmus pectinirostris) Are Under Positive Selection and Respond Differently to LPS/Poly(I:C) Challenge

Frontiers in Immunology, 2019
Toll-like receptors (TLRs) are major molecular pattern recognition receptors, which are essential for triggering a series of innate immune responses against invading pathogens by recognizing their evolutionary conserved molecular patterns. The mudskipper,
Heng Tong Qiu, Jorge M. O. Fernandes, Wan Shu Hong, Wan Shu Hong, Hai Xu Wu, Yu Ting Zhang, Sheng Huang, Dong Teng Liu, Hui Yu, Qiong Wang, Xin Xin You, Shi Xi Chen, Shi Xi Chen, Shi Xi Chen   +13 more
doaj   +1 more source

Interplay of Various Evolutionary Modes in Genome Diversification and Adaptive Evolution of the Family Sulfolobaceae

Frontiers in Microbiology, 2021
Sulfolobaceae family, comprising diverse thermoacidophilic and aerobic sulfur-metabolizing Archaea from various geographical locations, offers an ideal opportunity to infer the evolutionary dynamics across the members of this family.
Rachana Banerjee, Narendrakumar M. Chaudhari, Abhishake Lahiri, Abhishake Lahiri, Anupam Gautam, Anupam Gautam, Debaleena Bhowmik, Debaleena Bhowmik, Chitra Dutta, Sujay Chattopadhyay, Daniel H. Huson, Daniel H. Huson, Sandip Paul, Sandip Paul   +13 more
doaj   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source