Results 11 to 20 of about 9,021,030 (297)

Being positive about selection. [PDF]

PLoS Biology, 2006
Detecting positive selection at the molecular level has recently become easier and editors of PLoS Biology face the challenge of identifying standards of excellence in the face of burgeoning interest in this field.
Catriona MacCallum, Emma Hill
doaj   +3 more sources

Multilocus patterns of nucleotide variability and the demographic and selection history of drosophila melanogaster populations [PDF]

, 2005
Uncertainty about the demographic history of populations can hamper genome-wide scans for selection based on population genetic models. To obtain a portrait of the effects of demographic history on genome variability patterns in Drosophila melanogaster ...
Haddrill, Penelope R, Charlesworth, B, Haddrill, P R, Charlesworth, Brian, Thornton, K R, Thornton, Kevin R, Andolfatto, Peter, Andolfatto, P   +7 more
core   +4 more sources

Positive Selection in East Asians for an EDAR Allele that Enhances NF-κB Activation [PDF]

, 2008
Genome-wide scans for positive selection in humans provide a promising approach to establish links between genetic variants and adaptive phenotypes.
Hughes, David, Myles, Sean, Strotmann, Rainer, Stoneking, M. ; https://orcid.org/, Hughes, D., Pugach, Irina, Hardouin, Emilie, Stajich, Jason E., Jarosław Bryk, Pugach, I., Sean Myles, Hughes, D. ; https://orcid.org/, Jarosław Bryk, Mark Stoneking, Stoneking, Mark, Myles, S., Bryk, J., Bryk, Jarosław, Stoneking, M., Bryk, Jarek, Emilie Hardouin, Hughes, David A., Hardouin, E., Pugach, I. ; https://orcid.org/, Rainer Strotmann, Hardouin, E. ; https://orcid.org/, Myles, S. ; https://orcid.org/, Irina Pugach, David Hughes, Hardouin, E.A., Strotmann, R.   +30 more
core   +1 more source

Detecting positive selection in the genome

BMC Biology, 2017
Population geneticists have long sought to understand the contribution of natural selection to molecular evolution. A variety of approaches have been proposed that use population genetics theory to quantify the rate and strength of positive selection ...
Tom R. Booker, Benjamin C. Jackson, Peter D. Keightley   +2 more
doaj   +1 more source

ON THE SELECTION OF POSITIONS FOR CATHETERISM. [PDF]

The Lancet, 1873
n ...
openaire   +2 more sources

DNA repair-related genes are the key for stony coral ancestors to survive under elevated levels of UVR

Frontiers in Marine Science, 2023
DNA damage response (DDR) is a complicated network to defend against physical or chemical changes in DNA in all animals. Elevated levels of ultraviolet radiation (UVR) caused DNA damage, which was a reason for the mass extinction that occurred at the ...
Tianzhen Wu, Tianzhen Wu, Yanli Lei, Yanli Lei, Yanli Lei, Zhimin Jian   +5 more
doaj   +1 more source

Population size may shape the accumulation of functional mutations following domestication

BMC Evolutionary Biology, 2018
Background Population genetics theory predicts an important role of differences in the effective population size (N e ) among species on shaping the accumulation of functional mutations by regulating the selection efficiency.
Jianhai Chen, Pan Ni, Xinyun Li, Jianlin Han, Ivan Jakovlić, Chengjun Zhang, Shuhong Zhao   +6 more
doaj   +1 more source

The role of positive selection in determining the molecular cause of species differences in disease [PDF]

, 2008
Related species, such as humans and chimpanzees, often experience the same disease with varying degrees of pathology, as seen in the cases of Alzheimer's disease, or differing symptomatology as in AIDS. Furthermore, certain diseases such as schizophrenia,
Vamathevan, JJ, Heather Amrine-Madsen, Topp Simon D, Rajagopalan, D, Hasan Samiul, Sanseau, P, Jessica J Vamathevan, Samiul Hasan, Yang Ziheng, Hasan, S, Amrine-Madsen, H, Kumar Vinod, Rajagopalan Dilip, Simmons, MD, Simon D Topp, Joanna D Holbrook, Sanseau Philippe, Simmons Mark D, Vinod Kumar, Ziheng Yang, Mark D Simmons, Richard D Emes, Philippe Sanseau, Emes, RD, Holbrook Joanna D, Yang, Z, Dilip Rajagopalan, Foord, SM, Vamathevan Jessica J, Michael Word, Holbrook, JD, Kumar, V, Topp, SD, Word, M, Emes Richard D, Steven M Foord, Foord Steven M, Amrine-Madsen Heather, Word Michael   +38 more
core   +1 more source

POSITIVe Newsletter [PDF]

, 2017
Take a look at the ‘Getting-to-know your POSITIVe partners” section to get familiarized with more senior and young researchers belonging to this COST Action.
Garcia Conesa, Maria-Teresa, Kieda, Iwona, Ruskovska, Tatjana   +2 more
core   +2 more sources

Selective Role of NFATc3 in Positive Selection of Thymocytes [PDF]

The Journal of Immunology, 2007
Abstract The four Ca2+-dependent NFATc proteins are both signal transducers and transcription factors that reside in the cytoplasm until dephosphorylation by calcineurin. Dephosphorylation exposes nuclear import sequences and sends NFATc proteins into the nucleus where they assemble with nuclear partners into NFAT transcription complexes.
Kirsten, Canté-Barrett, Monte M, Winslow, Gerald R, Crabtree   +2 more
openaire   +2 more sources