Results 1 to 10 of about 571,058 (223)

m1A Post‐Transcriptional Modification in tRNAs [PDF]

Biomolecules, 2017
To date, about 90 post‐transcriptional modifications have been reported in tRNA expanding their chemical and functional diversity. Methylation is the most frequent post‐transcriptional tRNA modification that can occur on almost all nitrogen sites of
Stephanie Oerum, Clément Dégut, Pierre Barraud, Carine Tisné   +3 more
doaj   +3 more sources

An extended dsRBD is required for post-transcriptional modification in human tRNAs. [PDF]

Nucleic Acids Res, 2015
In tRNA, dihydrouridine is a conserved modified base generated by the post-transcriptional reduction of uridine. Formation of dihydrouridine 20, located in the D-loop, is catalyzed by dihydrouridine synthase 2 (Dus2).
Bou-Nader C, Pecqueur L, Bregeon D, Kamah A, Guérineau V, Golinelli-Pimpaneau B, Guimarães BG, Fontecave M, Hamdane D.   +8 more
europepmc   +4 more sources

Transcriptome-wide m⁶A profiling reveals mRNA post-transcriptional modification of boar sperm during cryopreservation. [PDF]

BMC Genomics, 2021
Cryopreservation induces transcriptomic and epigenetic modifications that strongly impairs sperm quality and function, and thus decrease reproductive performance.
Qin Z, Wang W, Ali MA, Wang Y, Zhang Y, Zhang M, Zhou G, Yang JD, Zeng C.   +8 more
europepmc   +4 more sources

Combining tRNA sequencing methods to characterize plant tRNA expression and post-transcriptional modification. [PDF]

RNA Biol, 2021
Differences in tRNA expression have been implicated in a remarkable number of biological processes. There is growing evidence that tRNA genes can play dramatically different roles depending on both expression and post-transcriptional modification, yet ...
Warren JM, Salinas-Giegé T, Hummel G, Coots NL, Svendsen JM, Brown KC, Drouard L, Sloan DB.   +7 more
europepmc   +2 more sources

MiRNA post-transcriptional modification dynamics in T cell activation [PDF]

iScience, 2021
Summary: T cell activation leads to extensive changes in the miRNA repertoire. Although overall miRNA expression decreases within a few hours of T cell activation, some individual miRNAs are specifically upregulated.
Ana Rodríguez-Galán, Sara G. Dosil, Manuel José Gómez, Irene Fernández-Delgado, Lola Fernández-Messina, Fátima Sánchez-Cabo, Francisco Sánchez-Madrid   +6 more
doaj   +2 more sources

KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3. [PDF]

Mol Cancer, 2019
N6-methyladenosine (m6A) modification, the most abundant internal methylation of eukaryotic RNA transcripts, is critically implicated in RNA processing.
Lan T, Li H, Zhang D, Xu L, Liu H, Hao X, Yan X, Liao H, Chen X, Xie K, Li J, Liao M, Huang J, Yuan K, Zeng Y, Wu H.   +15 more
europepmc   +2 more sources

Post-Transcriptional Regulation of Viral RNA through Epitranscriptional Modification

Cells, 2021
The field of mRNA modifications has been steadily growing in recent years as technologies have improved and the importance of these residues became clear.
David G. Courtney
doaj   +2 more sources

Post-Transcriptional Modifications of Conserved Nucleotides in the T-Loop of tRNA: A Tale of Functional Convergent Evolution [PDF]

Genes, 2021
The high conservation of nucleotides of the T-loop, including their chemical identity, are hallmarks of tRNAs from organisms belonging to the three Domains of Life.
Martine Roovers, Louis Droogmans, Henri Grosjean   +2 more
openalex   +2 more sources

Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements

Cell Reports, 2016
MicroRNAs (miRNAs) regulate diverse biological processes by repressing mRNAs, but their modest effects on direct targets, together with their participation in larger regulatory networks, make it challenging to delineate miRNA-mediated effects.
Sara J.C. Gosline, Allan M. Gurtan, Courtney K. JnBaptiste, Andrew Bosson, Pamela Milani, Simona Dalin, Bryan J. Matthews, Yoon S. Yap, Phillip A. Sharp, Ernest Fraenkel   +9 more
doaj   +2 more sources

MicroRNA-1 aggravates cardiac oxidative stress by post-transcriptional modification of the antioxidant network. [PDF]

Cell Stress Chaperones, 2015
Wang L, Yuan Y, Li J, Ren H, Cai Q, Chen X, Liang H, Shan H, Fu ZD, Gao X, Lv Y, Yang B, Zhang Y.   +12 more
europepmc   +2 more sources