Results 11 to 20 of about 348,774 (324)
Post-transcriptional nucleotide modification and alternative folding of RNA [PDF]
Nucleic Acids Research, 2006 Alternative foldings are an inherent property of RNA and a ubiquitous problem in scientific investigations. To a living organism, alternative foldings can be a blessing or a problem, and so nature has found both, ways to harness this property and ways to avoid the drawbacks.
Mark Helm
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Post-transcriptional modifications are very important after all [PDF]
RNA Biology, 2014 In the beginning there was RNA and our lives as molecular biologists and biochemists proceeded simply.
Juan Alfonzo
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Post-transcriptional modification of spliceosomal RNAs is normal in SMN-deficient cells [PDF]
RNA, 2011 The survival of motor neuron (SMN) protein plays an important role in the biogenesis of spliceosomal snRNPs and is one factor required for the integrity of nuclear Cajal bodies (CBs). CBs are enriched in small CB-specific (sca) RNAs, which guide the formation of pseudouridylated and 2′-O-methylated residues in the snRNAs.
Svetlana Deryusheva +4 more
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The role of post-transcriptional modifications during development
Biologia Futura, 2022 AbstractWhile the existence of post-transcriptional modifications of RNA nucleotides has been known for decades, in most RNA species the exact positions of these modifications and their physiological function have been elusive until recently. Technological advances, such as high-throughput next-generation sequencing (NGS) methods and nanopore-based ...
Renáta Hamar, Máté Varga
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Post-transcriptional modifications in development and stem cells [PDF]
Development, 2016 Cells adapt to their environment by linking external stimuli to an intricate network of transcriptional, post-transcriptional and translational processes. Among these, mechanisms that couple environmental cues to the regulation of protein translation are not well understood.
Sandra Blanco +2 more
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The emerging biology of RNA post-transcriptional modifications [PDF]
RNA Biology, 2017 RNA modifications have long been known to be central in the proper function of tRNA and rRNA. While chemical modifications in mRNA were discovered decades ago, their function has remained largely mysterious until recently. Using enrichment strategies coupled to next generation sequencing, multiple modifications have now been mapped on a transcriptome ...
Sigrid Nachtergaele, Chuan He
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Distribution and frequencies of post-transcriptional modifications in tRNAs [PDF]
RNA Biology, 2014 Functional tRNA molecules always contain a wide variety of post-transcriptionally modified nucleosides. These modifications stabilize tRNA structure, allow for proper interaction with other macromolecules and fine-tune the decoding of mRNAs during translation. Their presence in functionally important regions of tRNA is conserved in all domains of life.
Anna Olchowik +3 more
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Post-transcriptional gene regulation by mRNA modifications [PDF]
Nature Reviews Molecular Cell Biology, 2016 The recent discovery of reversible mRNA methylation has opened a new realm of post-transcriptional gene regulation in eukaryotes. The identification and functional characterization of proteins that specifically recognize RNA N6-methyladenosine (m6A) unveiled it as a modification that cells utilize to accelerate mRNA metabolism and translation.
Boxuan Simen Zhao +2 more
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Post-Transcriptional Modifications of RNA as Regulators of Apoptosis in Glioblastoma
International Journal of Molecular Sciences, 2022 This review is devoted to changes in the post-transcriptional maturation of RNA in human glioblastoma cells, which leads to disruption of the normal course of apoptosis in them. The review thoroughly highlights the latest information on both post-transcriptional modifications of certain regulatory RNAs, associated with the process of apoptosis ...
Anton Dome +3 more
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Detecting RNA modification using direct RNA sequencing: A systematic review
Computational and Structural Biotechnology Journal, 2022 Post-transcriptional RNA modifications are involved in a range of important cellular processes, including the regulation of gene expression and fine-tuning of the functions of RNA molecules.
Xichen Zhao +4 more
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