Results 11 to 20 of about 571,207 (361)

Transcriptional and Post-transcriptional Regulation of Lignin Biosynthesis Pathway Genes in Populus

Frontiers in Plant Science, 2020
Lignin is a heterogeneous polymer of aromatic subunits derived from phenylalanine. It is polymerized in intimate proximity to the polysaccharide components in plant cell walls and provides additional rigidity and compressive strength for plants ...
Jin Zhang, Jin Zhang, Gerald A. Tuskan, Gerald A. Tuskan, Timothy J. Tschaplinski, Timothy J. Tschaplinski, Wellington Muchero, Wellington Muchero, Jin-Gui Chen, Jin-Gui Chen   +9 more
doaj   +2 more sources

Fine-tuning thermogenesis from the post-transcriptional level [PDF]

iScience
Summary: In mammals, adipose tissue is involved in energy homeostasis regulation. White adipose tissue (WAT) is the major energy storage site for mammals, whereas brown adipose tissue (BAT) is involved in energy expenditure and thermogenesis.
Mengyao Wan, Hao Gu, Siyuan Chen, Zihao Guo, Bayindala Xiagedeer, Yaqun Guan, Xiaodi Liang   +6 more
doaj   +2 more sources

TRMT5 Mutations Cause a Defect in Post-transcriptional Modification of Mitochondrial tRNA Associated with Multiple Respiratory-Chain Deficiencies. [PDF]

Am J Hum Genet, 2015
Powell CA, Kopajtich R, D'Souza AR, Rorbach J, Kremer LS, Husain RA, Dallabona C, Donnini C, Alston CL, Griffin H, Pyle A, Chinnery PF, Strom TM, Meitinger T, Rodenburg RJ, Schottmann G, Schuelke M, Romain N, Haller RG, Ferrero I, Haack TB, Taylor RW, Prokisch H, Minczuk M.   +23 more
europepmc   +2 more sources

Post-transcriptional gene regulation by mRNA modifications [PDF]

Nature Reviews Molecular Cell Biology, 2016
The recent discovery of reversible mRNA methylation has opened a new realm of post-transcriptional gene regulation in eukaryotes. The identification and functional characterization of proteins that specifically recognize RNA N6-methyladenosine (m6A) unveiled it as a modification that cells utilize to accelerate mRNA metabolism and translation.
B. Zhao, I. A. Roundtree, Chuan He
semanticscholar   +3 more sources

Regulatory role of RNA N6-methyladenosine modifications during skeletal muscle development

Frontiers in Cell and Developmental Biology, 2022
Functional cells in embryonic myogenesis and postnatal muscle development undergo multiple stages of proliferation and differentiation, which are strict procedural regulation processes.
Baojun Yu, Jiamin Liu, Juan Zhang, Tong Mu, Xiaofang Feng, Ruoshuang Ma, Yaling Gu   +6 more
doaj   +1 more source

The role of post-transcriptional modifications during development

Biologia Futura, 2022
AbstractWhile the existence of post-transcriptional modifications of RNA nucleotides has been known for decades, in most RNA species the exact positions of these modifications and their physiological function have been elusive until recently. Technological advances, such as high-throughput next-generation sequencing (NGS) methods and nanopore-based ...
Renáta Hamar, Máté Varga
openaire   +4 more sources

The Potential Role of m⁶A in the Regulation of TBI-Induced BGA Dysfunction

Antioxidants, 2022
The brain–gut axis (BGA) is an important bidirectional communication pathway for the development, progress and interaction of many diseases between the brain and gut, but the mechanisms remain unclear, especially the post-transcriptional regulation of ...
Peizan Huang, Min Liu, Jing Zhang, Xiang Zhong, Chunlong Zhong   +4 more
doaj   +1 more source

A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs [PDF]

Nucleic Acids Research, 2014
In mammalian mitochondria, 22 species of tRNAs encoded in mitochondrial DNA play crucial roles in the translation of 13 essential subunits of the respiratory chain complexes involved in oxidative phosphorylation. Following transcription, mitochondrial tRNAs are modified by nuclear-encoded tRNA-modifying enzymes. These modifications are required for the
Takeo Suzuki, Takeo Suzuki
openalex   +3 more sources

Interplay of four types of RNA modification writers revealed distinct tumor microenvironment and biological characteristics in pancreatic cancer

Frontiers in Immunology, 2022
BackgroundPancreatic cancer (PC) is one of the most lethal malignancies and carries a dismal mortality and morbidity. Four types of RNA modification (namely m6A, m1A, APA and A-to-I) could be catalyzed by distinct enzymatic compounds (“writers ...
Wenzhe Gao, Dongjie Chen, Dongjie Chen, Dongjie Chen, Dongjie Chen, Jixing Liu, Jixing Liu, Longjun Zang, Tijun Xiao, Xianlin Zhang, Zheng Li, Hongwei Zhu, Xiao Yu   +12 more
doaj   +1 more source

The emerging biology of RNA post-transcriptional modifications [PDF]

RNA Biology, 2017
RNA modifications have long been known to be central in the proper function of tRNA and rRNA. While chemical modifications in mRNA were discovered decades ago, their function has remained largely mysterious until recently. Using enrichment strategies coupled to next generation sequencing, multiple modifications have now been mapped on a transcriptome ...
Sigrid, Nachtergaele, Chuan, He
openaire   +2 more sources