Results 181 to 190 of about 7,761,523 (290)

Dual transcriptional and post-transcriptional regulation by the bHLH proteins Rtg1 and RtgX in Komagataella phaffii. [PDF]

Nucleic Acids Res
Rajak N, Shah R, Sharma Y, Rangarajan P.
europepmc   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

A web-based atlas for exploring post-transcriptional regulation in the archaeon <i>Sulfolobus acidocaldarius</i>. [PDF]

mSystems
Brück M, Daume M, Randau L, Gomes-Filho JV.   +3 more
europepmc   +1 more source

Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo, Claudia Dosi, Stefano Parravicini, Riccardo Zanin, Marta Cheli, Eleonora Giacopuzzi Grigoli, Amalia Canciello, Francesca Andreetta, Riccardo Masson, Silvia Bonanno, Stefania Marcuzzo, Lorenzo Maggi   +11 more
wiley   +1 more source

Identification of post-transcriptional regulation reveals complexity in peanut pod development by Direct RNA. [PDF]

aBIOTECH
Wang W, Guo H, Bian J, Cui F, Liu X.
europepmc   +1 more source

Generative AI in clinical practice: how should rheumatologists evaluate and monitor emerging tools?

Arthritis Care &Research, Accepted Article.
Generative artificial intelligence (AI) is increasingly being used in rheumatology practice, to assist with tasks such as documentation, record summarization, and clinical decision support. Rheumatologists need a practical approach to determining what evidence and oversight each application requires.
Koushan Kouranloo, Mrinalini Dey, Jinoos Yazdany   +2 more
wiley   +1 more source

Editorial: Transcriptional and post-transcriptional regulatory networks in cellular homeostasis and stress response

Frontiers in Molecular Biosciences
Alessandra Boccaccini, Davide Capauto, Matteo Cassandri, Silvia Santopolo   +3 more
doaj   +1 more source

T6SS4 is heterogeneously expressed in Yersinia pseudotuberculosis and is a target for transcriptional and post-transcriptional regulation. [PDF]

PLoS Pathog
Kerwien A, Körner B, Meyer I, Teschke Y, Köster CS, Salto IP, Dersch P, Herbrüggen AS.   +7 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Post-transcriptional regulation by HuR in colorectal cancer: impacts on tumor progression and therapeutic strategies. [PDF]

Front Immunol
Shi Y, Zhou Z, Liu C, Liu J, Xie M, Chen X, Dixon DA, Wu X, Yang L.   +8 more
europepmc   +1 more source