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Allosteric post-translational modification codes
Trends in Biochemical Sciences, 2012Post-translational modifications (PTMs) have been recognized to impact protein function in two ways: (i) orthosterically, via direct recognition by protein domains or through interference with binding; and (ii) allosterically, via conformational changes induced at the functional sites.
Ruth, Nussinov +3 more
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Post-translational Modification in Muscular Dystrophies
2022Muscular dystrophies are a complex group of inherited neuromuscular disorders that progressively lead to a loss of muscle fibers and mobility and muscle weakness; over time, they evolve to an increasing level of disability. Muscular dystrophies are mostly caused by genetic mutations in proteins responsible for maintaining sarcolemma structures, such as
Sandonà M., Saccone V.
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Post-Translational Modifications
1982During the past three decades there have been major improvements in the techniques for isolating and characterizing proteins. As a consequence of the application of these improved procedures it has become apparent that proteins are not simple linear polymers of amino acids but have three–dimensional structure. Many proteins consist of several component
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Post-translational modifications and chromatin dynamics
Essays in Biochemistry, 2019Abstract The dynamic structure of chromatin is linked to gene regulation and many other biological functions. Consequently, it is of importance to understand the factors that regulate chromatin dynamics. While the in vivo analysis of chromatin has verified that histone post-translational modifications play a role in modulating DNA ...
Thomas O. Tolsma, Jeffrey C. Hansen
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Post-translational Modifications of Centromeric Chromatin
2017Regulation of chromatin structures is important for the control of DNA processes such as gene expression, and misregulation of chromatin is implicated in diverse diseases. Covalent post-translational modifications of histones are a prominent way to regulate chromatin structure and different chromatin regions bear their specific signature of histone ...
García del Arco, Ana, Erhardt, Sylvia
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Post-translational Modifications in Parkinson’s Disease
2022Parkinson's disease (PD) is a complex neurodegenerative disorder characterised by progressive degeneration of the dopaminergic neurons in the substantia nigra leading to severe motor complications. The etiology of the disease is unknown with its sporadic form accounting for 90% of cases.
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Post‐translational modification and phenotype
PROTEOMICS, 2023Barbora Salovska, Yansheng Liu
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Post-translational modifications of protein biopharmaceuticals
Drug Discovery Today, 2010The majority of therapeutic proteins display one or more post-translational modifications (PTMs). These modifications normally influence the biochemical and therapeutic properties of such proteins. Choosing an expression system capable of generating an appropriate product PTM profile remains one of the most crucial decisions a drug developer must make.
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