Oxidatively Modified Proteins: Cause and Control of Diseases
Applied Sciences, 2020 Proteins succumb to numerous post-translational modifications (PTMs). These relate to enzymatic or non-enzymatic reactions taking place in either the intracellular or extracellular compartment.
Ramona Clemen, Sander Bekeschus
doaj +1 more source
Identification of N-terminal protein acetylation and arginine methylation of the voltage-gated sodium channel in end-stage heart failure human heart [PDF]
, 2014 The α subunit of the cardiac voltage-gated sodium channel, Naᵥ1.5, provides the rapid sodium inward current that initiates cardiomyocyte action potentials.
Batlle, Montserrat +13 more
core +1 more source
Potential protein post-translational modification in ERp57: A phenotype marker for male fertility
Journal of Human Reproductive Sciences, 2010 Background : In protein expression, post-translational modification is an important process. It is also an important process in human reproductive science. ERp57 is a molecule that is mentioned for post-translational modification. ERp57 is a component of
Viroj Wiwanitkit
doaj +1 more source
Correction: Post-translational modifications on the retinoblastoma protein [PDF]
Journal of Biomedical ScienceLinbin Zhou +6 more
doaj +2 more sources
Regulating tumor suppressor genes: post-translational modifications
Signal Transduction and Targeted Therapy, 2020 Tumor suppressor genes cooperate with each other in tumors. Three important tumor suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted on chromosome ten (PTEN) are functionally associated and they regulated by post ...
Ling Chen, Shuang Liu, Y. Tao
semanticscholar +1 more source
Post-translational protein modifications in schizophrenia [PDF]
npj Schizophrenia, 2020 AbstractResearch investigating the pathophysiology of schizophrenia has not yet precisely defined the molecular phenotype of this disorder. Many studies have investigated cellular dysfunction by examining expression levels of molecular targets in postmortem patient brain; however, inconsistencies between transcript and protein measures in schizophrenia
Toni M. Mueller +1 more
openaire +2 more sources
Post‐translation modification of proteins in tears [PDF]
ELECTROPHORESIS, 2010 AbstractThis is the first 2‐DE study using sequential dyes to analyse phospho‐, glyco‐ and total tear protein profiles (Pro‐Q Diamond for phosphoprotein, Pro‐Q Emerald for glycoprotein and Sypro Ruby for total protein). This method minimised the gel–gel variations, allowing better comparisons among the three profiles and generated a whole map of PTM ...
Yong Li +14 more
openaire +3 more sources
The Roles of Post-Translational Modifications in STAT3 Biological Activities and Functions
Biomedicines, 2021 STAT3 is an important transcription factor that regulates cell growth and proliferation by regulating gene transcription of a plethora of genes. This protein also has many roles in cancer progression and several tumors such as prostate, lung, breast, and
Annachiara Tesoriere +2 more
semanticscholar +1 more source
SLoMo: automated site localization of modifications from ETD/ECD mass spectra [PDF]
, 2009 Recently, software has become available to automate localization of phosphorylation sites from CID data and to assign associated confidence scores. We present an algorithm, SLoMo (Site Localization of Modifications), which extends this capability to ETD ...
Bailey, Christopher M +5 more
core +1 more source
Post-translational modifications of transporters
Pharmacology & Therapeutics, 2018 Drug transporter proteins are critical to the distribution of a wide range of endogenous compounds and xenobiotics such as hormones, bile acids, peptides, lipids, sugars, and drugs. There are two classes of drug transporters- the solute carrier (SLC) transporters and ATP-binding cassette (ABC) transporters -which predominantly differ in the energy ...
Lindsay C. Czuba +2 more
openaire +4 more sources