Post-translational modifications of the polycystin proteins [PDF]
Cellular Signalling, 2020 Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of kidney failure and affects up to 12 million people worldwide. Germline mutations in two genes, PKD1 or PKD2, account for almost all patients with ADPKD.
Streets, A., Ong, A.
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The Expanding Constellation of Histone Post-Translational Modifications in the Epigenetic Landscape
Genes, 2021 The emergence of a nucleosome-based chromatin structure accompanied the evolutionary transition from prokaryotes to eukaryotes. In this scenario, histones became the heart of the complex and precisely timed coordination between chromatin architecture and
V. Cavalieri
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Mycobacterium tuberculosis H37Ra: a surrogate for the expression of conserved, multimeric proteins of M.tb H37Rv [PDF]
, 2016 Additional file 3. Details of primers used, experimental and theoretical molecular weights, pI values and details of post-translational modifications in ...
Ajay Kumar +13 more
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Regulation of the NLRP3 Inflammasome by Post-Translational Modifications and Small Molecules
Frontiers in Immunology, 2021 Inflammation is a host protection mechanism that eliminates invasive pathogens from the body. However, chronic inflammation, which occurs repeatedly and continuously over a long period, can directly damage tissues and cause various inflammatory and ...
J. Seok +4 more
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Post-translational modifications of Hsp70 family proteins: Expanding the chaperone code
Journal of Biological Chemistry, 2020 Cells must be able to cope with the challenge of folding newly synthesized proteins and refolding those that have become misfolded in the context of a crowded cytosol. One such coping mechanism that has appeared during evolution is the expression of well-
Nitika +3 more
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Analysis of histone post translational modifications in primary monocyte derived macrophages using reverse phase×reverse phase chromatography in conjunction with porous graphitic carbon stationary phase. [PDF]
, 2016 A two dimensional-liquid chromatography (2D-LC) based approach was developed for the identification and quantification of histone post translational modifications in conjunction with mass spectrometry analysis.
Cole, J. +4 more
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Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury [PDF]
, 2016 It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining ...
Carter, Wayne +8 more
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Orchestrating the proteome with post-translational modifications [PDF]
Journal of Experimental Botany, 2018 Post-translational modifications (PTMs) add tremendous complexity to cellular proteomes. The large variety of these modifications and their concurrent appearance in proteins dramatically increase the proteome size from mere thousands to the order of millions of possible protein forms.
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Phosphorylation of CENP-A on serine 7 does not control centromere function [PDF]
, 2019 CENP-A is the histone H3 variant necessary to specify the location of all eukaryotic centromeres via its CENP-A targeting domain and either one of its terminal regions.
Aslanian A. +9 more
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Deciphering post‐translational modification codes [PDF]
FEBS Letters, 2013 Post‐translational modifications (PTMs) occur on nearly all proteins. Many domains within proteins are modified on multiple amino acid sidechains by diverse enzymes to create a myriad of possible protein species. How these combinations of PTMs lead to distinct biological outcomes is only beginning to be understood.
Matthew P. Torres +2 more
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