Results 71 to 80 of about 541,798 (360)
Post-translational modifications of Hsp90 and their contributions to chaperone regulation [PDF]
, 2012 Molecular chaperones, as the name suggests, are involved in folding, maintenance, intracellular transport, and degradation of proteins as well as in facilitating cell signaling. Heat shock protein 90 (Hsp90) is an essential eukaryotic molecular chaperone
Mollapour, Mehdi, Neckers, Len
core +1 more source
Regulation of Lignin Biosynthesis by Post-translational Protein Modifications
Frontiers in Plant Science, 2020 Post-translational modification of proteins exerts essential roles in many biological processes in plants. The function of these chemical modifications has been extensively characterized in many physiological processes, but how these modifications ...
Daniel B. Sulis, Jack P. Wang
doaj +1 more source
Post-translational modifications of Hsp90 and translating the chaperone code
Journal of Biological Chemistry, 2020 Cells have a remarkable ability to synthesize large amounts of protein in a very short period of time. Under these conditions, many hydrophobic surfaces on proteins may be transiently exposed, and the likelihood of deleterious interactions is quite high.
Sarah J. Backe +4 more
semanticscholar +1 more source
Multiple mechanisms of growth hormone-regulated gene transcription [PDF]
, 2007 Diverse physiological actions of growth hormone (GH) are mediated by changes in gene transcription. Transcription can be regulated at several levels, including post-translational modification of transcription factors, and formation of multiprotein ...
Calinescu, Anda Alexandra +8 more
core +1 more source
Targeting DNA-Protein Crosslinks via Post-Translational Modifications
Frontiers in Molecular Biosciences, 2022 Covalent binding of proteins to DNA forms DNA-protein crosslinks (DPCs), which represent cytotoxic DNA lesions that interfere with essential processes such as DNA replication and transcription.
Xueyuan Leng, Julien P. Duxin
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Pharmacological Reviews, 2020 G protein–coupled receptors (GPCRs) are a large family comprising >800 signaling receptors that regulate numerous cellular and physiologic responses.
Anand R. Patwardhan +2 more
semanticscholar +1 more source
Nature Communications, 2020 The mechanisms by which deubiquitinases modulate tumour progression are not fully understood. Here, the authors perform an RNAi screen and identify that the deubiquitinase OTUD5 suppresses cancer growth in a TRIM25 dependent manner, which in turn ...
Fangzhou Li +15 more
doaj +1 more source
Regulation of Viral Restriction by Post-Translational Modifications
Viruses, 2021 Intrinsic immunity is orchestrated by a wide range of host cellular proteins called restriction factors. They have the capacity to interfere with viral replication, and most of them are tightly regulated by interferons (IFNs).
Célia Chamontin +4 more
doaj +1 more source
Post translational modifications of milk proteins in geographically diverse goat breeds
Scientific Reports, 2021 Goat milk is a source of nutrition in difficult areas and has lesser allerginicity than cow milk. It is leading in the area for nutraceutical formulation and drug development using goat mammary gland as a bioreactor. Post translational modifications of a
P. K. Rout, M. Verma
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Molecular Cancer, 2016 The epithelial to mesenchymal transition (EMT) is a biological process in which a non-motile epithelial cell changes to a mesenchymal phenotype with invasive capacities.
S. J. Serrano-Gómez +2 more
semanticscholar +1 more source