Results 101 to 110 of about 76,851 (293)

Controllability of protein-protein interaction phosphorylation-based networks: Participation of the hub 14-3-3 protein family [PDF]

, 2016
Posttranslational regulation of protein function is an ubiquitous mechanism in eukaryotic cells. Here, we analyzed biological properties of nodes and edges of a human protein-protein interaction phosphorylation-based network, especially of those nodes ...
Bustos, Diego Martin, Flores, Gabriel, Uhart, Marina   +2 more
core   +1 more source

Natural Design of a Stabilized Cross‐β Fold: Structure of the FuA FapC from Pseudomonas Sp. UK4 Reveals a Critical Role for Stacking of Imperfect Repeats

Advanced Materials, EarlyView.
We report a 3.2 Å cryoEM structure of functional amyloid protein FapC from Pseudomonas sp. UK4, an essential component of bacterial biofilm, which reveals a Greek key‐shaped protofilament, supports bioinformatically determined motifs, nuances AlphaFold predictions, emphasizes heterogeneous cross‐β stacking in amyloid cross‐seeding and shows strain ...
Yanting Jiang, Samuel Peña‐Díaz, Zhefei Zhang, Anders Ogechi Hostrup Daugberg, Marcos López Hernández, Janni Nielsen, Qiaojie Huang, Shenghan Qin, Morten K. D. Dueholm, Mingdong Dong, Jan Skov Pedersen, Qin Cao, Daniel E. Otzen, Huabing Wang   +13 more
wiley   +1 more source

Linking post-translational modifications and protein turnover by site-resolved protein turnover profiling

Nature Communications, 2022
Post-translational modifications (PTMs) can regulate cellular protein function but their global impact on protein turnover is largely unknown. Here, the authors develop proteomic workflows to profile PTM-resolved protein turnover and analyze the effects ...
Jana Zecha, Wassim Gabriel, Ria Spallek, Yun-Chien Chang, Julia Mergner, Mathias Wilhelm, Florian Bassermann, Bernhard Kuster   +7 more
doaj   +1 more source

A Review of Machine Learning and Algorithmic Methods for Protein Phosphorylation Sites Prediction [PDF]

arXiv, 2022
Post-translational modifications (PTMs) have key roles in extending the functional diversity of proteins and as a result, regulating diverse cellular processes in prokaryotic and eukaryotic organisms. Phosphorylation modification is a vital PTM that occurs in most proteins and plays a significant role in many biological processes.
arxiv  

Claws, Disorder, and Conformational Dynamics of the C-terminal Region of Human Desmoplakin [PDF]

The Journal of Physical Chemistry B (2016), 2016
Multicellular organisms consist of cells that interact via elaborate adhesion complexes. Desmosomes are membrane-associated adhesion complexes that mechanically tether the cytoskeletal intermediate filaments (IFs) between two adjacent cells, creating a network of tough connections in tissues such as skin and heart.
arxiv   +1 more source

Bioprocess Development for Lantibiotic Ruminococcin-A Production in Escherichia coli and Kinetic Insights Into LanM Enzymes Catalysis [PDF]

, 2019
Ruminococcin-A (RumA) is a peptide antibiotic with post-translational modifications including thioether cross-links formed from non-canonical amino acids, called lanthionines, synthesized by a dedicated lanthionine-generating enzyme RumM.
Adrian, Lorenz, Neubauer, Peter, Ongey, Elvis L., Riedel, Sebastian L., Santolin, Lara, Waldburger, Saskia   +5 more
core   +1 more source

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

Advanced Science, EarlyView.
This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang, Jinming Liu, Yanling Gou, Honglin Wang, Zhi Li, Yingying Cao, Huiyan Zhang, Ruru Bai, Zongfeng Zhang   +8 more
wiley   +1 more source

The role of histone post-translational modifications in cancer and cancer immunity: functions, mechanisms and therapeutic implications

Frontiers in Immunology
Histones play crucial roles in both promoting and repressing gene expression, primarily regulated through post-translational modifications (PTMs) at specific amino acid residues.
Xiaohong Duan, Xiaohong Duan, Xiaohong Duan, Zhiyao Xing, Zhiyao Xing, Zhiyao Xing, Lu Qiao, Shan Qin, Xuejing Zhao, Yanhua Gong, Yanhua Gong, Yanhua Gong, Xueren Li, Xueren Li   +13 more
doaj   +1 more source

(De)Activation (Ir)Reversibly or Degradation: Dynamics of Post-Translational Protein Modifications in Plants

Life, 2022
The increasing dynamic functions of post-translational modifications (PTMs) within protein molecules present outstanding challenges for plant biology even at this present day. Protein PTMs are among the first and fastest plant responses to changes in the
Victor Muleya, L. Maria Lois, Hicham Chahtane, Ludivine Thomas, Marco Chiapello, Claudius Marondedze   +5 more
doaj   +1 more source

Ridge Regression Estimated Linear Probability Model Predictions of O-glycosylation in Proteins with Structural and Sequence Data [PDF]

BMC Molecular and Cell Biology 2019, 2018
The likelihood of O-GlcNAc glycosylation in human proteins is predicted using the ridge regression estimated linear probability model (LPM). To achieve this, sequences from three similar post-translational modifications (PTMs) of proteins occurring at, or very near, the S or T site are analyzed: N-glycosylation, O-mucin type (O-GalNAc) glycosylation ...
arxiv   +1 more source