Results 131 to 140 of about 41,962 (282)
Animal Research and One Health, EarlyView.(1) Kbhb modification of FBP1 and PCK1 is involved in regulation of the gluconeogenesis pathway. (2) Kbhb of FBP1 and PCK1 is catalyzed by p300 and removed by HDACs. (3) BHB induced an increase in the enzymatic activity of FBP1 and PCK1 through Kbhb modification at the K43 site of FBP1 and the K191 site of PCK1.
DingPing Feng +6 more
wiley +1 more source
Veterinary SciencesPorcine reproductive and respiratory syndrome virus (PRRSV) is a highly contagious virus affecting pigs with significant impacts to the swine industry worldwide. This review provides a comprehensive understanding of post-translational modifications (PTMs)
Xiaoyong Chen, Jianlong Zhang
doaj +1 more source
ptm: Analyses of Protein Post-Translational Modifications [PDF]
, 2020 Juan Carlos Aledo
openalex +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT The competition in the biopharmaceutical market is increasing due to the market entry of biosimilars and rising costs in research and development of new drugs. Hence, continuous manufacturing gained significant attention due to its potential in reducing production cycle times and costs, as well as the possibility of real‐time release testing ...
Mariana Carvalho +4 more
wiley +1 more source
Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment
BMEMat, EarlyView.Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan +8 more
wiley +1 more source
Pharmacological ResearchInflammatory diseases, including infectious diseases, diabetes-related diseases, arthritis-related diseases, neurological diseases, digestive diseases, and tumor, continue to threaten human health and impose a significant financial burden despite ...
Ri-Wen +4 more
doaj +1 more source
Human Citrate Synthase Post-Translational Modification Mimics and Molecular Dynamic Simulations Demonstrate Attenuation of Acetyl-CoA/CoA Binding. [PDF]
ProteinsABSTRACT Human citrate synthase (hCS) is a mitochondrial enzyme that catalyzes the aldol condensation of acetyl coenzyme A (AcCoA) to oxaloacetate to form citrate in the TCA cycle. CS activity is important for aerobic exercise performance and basic metabolic function as a housekeeping enzyme.
Shackelford N +3 more
europepmc +2 more sources
Chemical Methods for Peptide and Protein Backbone Cleavage
ChemistryEurope, EarlyView.Protein cleavage plays essential roles in biology and is powerful for protein manipulation and functionalization as well as in recombinant expression and purification. Here, the historical background and most recent examples of chemical methods for protein and peptide backbone cleavage are discussed (part of the figure was generated in BioRender).
Miguel Angel Alena‐Rodriguez +1 more
wiley +1 more source
Bottom‐up Strategies for Generating Polymer Protocells That Mimic Cellular Communication
Chemistry – A European Journal, EarlyView.This review focuses on polymeric protocells produced using a bottom‐up approach. Polymer‐based assemblies guarantee stability and designability by adjusting the properties of the amphiphilic copolymers used. The review covers protocell architectures, production, and their intra‐ and intercellular communication mechanisms.
Gloria Saorin +3 more
wiley +1 more source