Results 191 to 200 of about 85,477 (330)
Lactylation in cancer biology: Unlocking new avenues for research and therapy
Cancer Communications, EarlyView.Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou +6 more
wiley +1 more source
Breaking barriers: the cGAS‐STING pathway as a novel frontier in cancer immunotherapy
Cancer Communications, EarlyView.Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan +5 more
wiley +1 more source
A thesis submitted in fulfilment of the examination requirements by Charlotte Neal.
openaire +2 more sources
Cancer Communications, EarlyView.Abstract Background Third‐generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) show initial efficacy in EGFR‐mutated lung cancer, but residual disease persists. This study aimed to investigate cluster of differentiation 24 (CD24) as a translational immunotherapeutic target for enhancing third‐generation EGFR‐TKI efficacy.
Jiaqi Liang +16 more
wiley +1 more source
Identification of Methylglyoxal Reactive Proteins with Photocaged Glycating Agents
ChemBioChem, EarlyView.Photocaged methylglyoxal (PC‐MGO) derivatives enable studying protein glycation under mild conditions. The active glycating agents can be released in the protein solution by irradiating the sample with UV light. Compared to the earlier reported chemically activated MGO probes, the photocaged probes are more potent.
Saskia Sokoliova +6 more
wiley +1 more source
Internal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases
ChemBioChem, EarlyView.GA: Genetically encoded internal electrophiles in ubiquitin (Ub) enable the profiling of multivalent interaction interfaces, addressing a key limitation of current Ub‐based activity‐based probes. In this study, these probes capture a Ub–deubiquitinase interaction with minimal structural perturbation and serve as selective diUb probes that covalently ...
Nipuni M. Pannala +7 more
wiley +1 more source
Profile of urinary amino acids and their post-translational modifications (PTM) including advanced glycation end-products (AGEs) of lysine, arginine and cysteine in lean and obese ZSF1 rats [PDF]
, 2021 Svetlana Baskal +6 more
openalex +1 more source
Model Classification for Predicting the Post-Translational Modification (PTM) Glycosylation in Sequence O Using an Extreme Gradient Boosting Algorithm [PDF]
Damayanti +4 more
openalex +1 more source
ChemBioChem, EarlyView.We show the optimization and application of a fluorogenic assay to monitor Legionella SdeA activity in a High‐Throughput‐Screening campaign. Ubiquitination of proteins is one of the most crucial post‐translational modifications in eukaryotic cells, typically involving conjugation of ubiquitin to a lysine residue in a substrate using a three‐enzyme ...
Halana C. Vlaming +6 more
wiley +1 more source