Results 211 to 220 of about 43,191 (287)

It's a Gas: Bioconjugation With Vapor‐Phase Reagents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
Gaseous reagents are an emerging class of bioconjugation reagents that can offer alternative selectivity paradigms for the construction of precise bioconjugates. A variety of both inert and highly reactive gases have recently been developed for bioconjugation use.
Yuxuan Ding, Jun Ohata, Zachary T. Ball
wiley   +1 more source

Unveiling the hidden regulators: how post-translational modifications influence the progression and treatment of hepatocellular carcinoma. [PDF]

Front Oncol
Qi S, Yong X, Ding Z, Hu M, Li Y, Li L, Hu H, Tang H.   +7 more
europepmc   +1 more source

Copper Overload Affects α‐Synuclein Clearance Mechanisms in a Parkinson's Disease In Vitro Model

Advanced Biology, Volume 10, Issue 5, May 2026.
This study reveals that copper overload disrupts neuronal protein clearance, leading to the accumulation of α‐synuclein and its phosphorylated form (p‐S129). By blocking autophagy and impairing the ubiquitin–proteasome system, copper promotes toxic aggregation in dopaminergic cells.
Debora Musarò, Marina Damato, Chiara Coppola, Marco Greco, Michele Maffia   +4 more
wiley   +1 more source

Succinylation: A novel regulatory axis in cholelithiasis-insights from lysine acetyltransferase 2A/adenosine monophosphate-activated protein kinase signaling. [PDF]

World J Gastroenterol
Wei HR, Xiao F.
europepmc   +1 more source

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, Volume 13, Issue 25, 4 May 2026.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

Phase Separation of Parkinson's Disease Protein α‐Synuclein: Mechanistic Insights but Biological Uncertainties

ChemistryEurope, Volume 4, Issue 5, May 2026.
Parkinson's disease‐associated protein α‐synuclein can assemble into liquid condensates under strongly perturbed in vitro and in vivo experimental conditions, including high protein concentration, macromolecular crowding, and when attached to various tags with cross‐linking ability.
Simran Arora, Pernilla Wittung‐Stafshede   +1 more
wiley   +1 more source

Exercise-specific post-translational modification signatures: unveiling precise regulatory mechanisms of molecular exercise language and cellular adaptation. [PDF]

Front Sports Act Living
Shen Y, Mao Z, Chen H, Zhu W, Guan Q, Yang Y, Liu J, Li L.   +7 more
europepmc   +1 more source

Computational Design of an mRNA Vaccine Targeting LRP6 for Triple‐Negative Breast Cancer Therapy

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Triple‐negative breast cancer (TNBC) presents a poorer prognosis than other breast cancer subtypes, attributed to its aggressive nature and the lack of specific therapeutic interventions. TNBC has high recurrence rates and limited survival despite current therapies, emphasizing the critical need for improved treatment options.
Pooriya Teimoori, Mohammadreza Heidari
wiley   +1 more source

Proteome analysis of lysine crotonylation modification in patients with psoriasis. [PDF]

PeerJ
Dong P, Hao C, Li H, Shen S, Gao J, Liang B, Zheng X, Tang H, Wang W.   +8 more
europepmc   +1 more source

Trends and Research Hotspots in Biomarkers of Sjögren's Syndrome Over the Past Two Decades: A Data‐Driven Atlas Analysis

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Background Sjögren's syndrome (SS) is a chronic, systemic inflammatory disorder primarily characterized by dry eyes and dry mouth, often involving multiple organ systems. The disease's heterogeneous clinical presentation and the absence of non‐invasive, specific biomarkers complicate its diagnosis and prognostic assessment.
Xinyan Zhang, Huan Li, Xueqing Zhou, Shangwen Qi, Songwei Li   +4 more
wiley   +1 more source