Results 221 to 230 of about 43,191 (287)

Post-translational modifications of silk proteins. [PDF]

RSC Chem Biol
Nomura K, Numata K.
europepmc   +1 more source

Ligand‐driven modulation of chaperone–cochaperone networks shapes proteostasis outcomes

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Protein homeostasis depends on a delicate interplay between folding and degradation, orchestrated by molecular chaperones. Among them, Hsp90 is a central hub, regulating nearly 10% of the proteome through ATP‐driven conformational cycles and selective interactions with cochaperones.
Andrea Magni, Giorgio Bonollo, Gauthier Trèves, Francesco Frigerio, Fabrizio Cinquini, Silvia Pavoni, A. Sofia F. Oliveira, Adrian J. Mulholland, Stefano A. Serapian, Giorgio Colombo   +9 more
wiley   +1 more source

Lactylation, Crotonylation and Succinylation: Decoding Their Roles in the Progression of Cardiovascular Disease. [PDF]

Rev Cardiovasc Med
Hu X, Zhang Y, Zhao Q, Li Y, Wu X.
europepmc   +1 more source

MAVISp: A modular structure‐based framework for protein variant effects

Protein Science, Volume 35, Issue 5, May 2026.
Abstract The role of genomic variants in disease has expanded significantly with the advent of advanced sequencing techniques. The rapid increase in identified genomic variants has led to many variants being classified as Variants of Uncertain Significance or as having conflicting evidence, posing challenges for their interpretation and ...
Matteo Arnaudi, Mattia Utichi, Kristine Degn, Matteo Tiberti, Ludovica Beltrame, Karolina Krzesińska, Pablo Sánchez‐Izquierdo Besora, Eleni Kiachaki, Simone Scrima, Laura Bauer, Katrine Meldgård, Anna Melidi, Lorenzo Favaro, Anu Oswal, Guglielmo Tedeschi, Terézia Dorčaková, Alberte Heering Estad, Joachim Breitenstein, Jordan Safer, Paraskevi Saridaki, Valentina Sora, Francesca Maselli, Philipp Becker, Jérémy Vinhas, Alberto Pettenella, Matteo Lambrughi, Claudia Cava, Anna Rohlin, Mef Nilbert, Sumaiya Iqbal, Peter Wad Sackett, Burcu Aykac Fas, Elena Papaleo   +32 more
wiley   +1 more source

Post-Transcriptional Modification Integration for Ligand-Receptor Cellular Network Inference. [PDF]

Mol Cell Proteomics
Giroux P, Maillard M, Colinge J.
europepmc   +1 more source

Calmodulin assists during co‐translational folding of the KV7.2 channel calcium responsive domain

Protein Science, Volume 35, Issue 5, May 2026.
Abstract In vivo, the majority of nascent protein chains begin folding during translation in order to reach their native structure. While the importance of co‐translational folding has become increasingly clear, the specific mechanisms underlying the coordination between the ribosome, the nascent chain and interacting partners are still uncertain. Here,
Arantza Muguruza‐Montero, Jack R. Tait, Sara M‐Alicante, Ane Metola, Eider Nuñez, Janire Urrutia, Vanda Sunderlíková, Alexandros Katranidis, Gunnar von Heijne, Sander J. Tans, Alvaro Villarroel   +10 more
wiley   +1 more source

MoSAIC: An Integrated and Modular Workflow for Confident Analysis of Protein Post-Translational Modification Landscapes. [PDF]

Mol Cell Proteomics
Xu Y, Chen L, Lih TM, Hu Y, Zhang H.
europepmc   +1 more source

Multiple disulfide‐bonded states confer extensive conformational diversity in fibrinogen

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Disulfide bonds constrain the polypeptide backbone and reduce conformational variability in proteins. The blood clotting protein fibrinogen is constitutively produced as multiple partially disulfide‐bonded states, suggesting that individual fibrinogen molecules have a variety of conformational forms.
Aster E. Pijning, Diego Butera, Philip J. Hogg   +2 more
wiley   +1 more source

The roles of post-translational modifications in the pathogenesis of RNA viruses: allies or adversaries? [PDF]

Front Microbiol
Shao T, Pei Z, Wang Y, Zhao Y, Fan H, Pan J.   +5 more
europepmc   +1 more source

Post-Translational Regulation of CD8⁺ T Cell Fate and Dysfunction in Tumor Immunity. [PDF]

Adv Sci (Weinh)
Zhou Z, Chen X, Li N, Zou M, Lin Y, Lin P, Feng W, Zhao X, Cui L.   +8 more
europepmc   +1 more source