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PTM-X: Prediction of Post-Translational Modification Crosstalk Within and Across Proteins
2022Posttranslational modifications (PTMs), which are processes of adding covalent groups in protein amino acids after the translation, play an important role in regulating proteins' localization, degradation, and functions. Different PTMs both within a single protein and across multiple proteins can work together or regulate reciprocally, known as PTM ...
Yuxuan, Li, Yuanhua, Huang, Tingting, Li
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Study of Post-Translational Modifications (PTMs) with Max Quant software
2022Post-translational modifications are covalent processing events that alter the function of the protein by adding a modifying group to one or more amino acids. Their detection and quantification are particularly challenging. We set up parameters that allowed us to detect glycosylation and acetylation by using an Orbitrab LC-MS/MS and we processed the ...
Beatrice Aiuto +7 more
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2014
Of the 25,000-30,000 human genes, about 2 % code for proteins. However, there are about one to two million protein entities. This is primarily due to alternative splicing and post-translational modifications (PTMs). Identifying all these modifications in one proteome at a particular time point during development or during the transition from normal to ...
Armand G, Ngounou Wetie +2 more
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Of the 25,000-30,000 human genes, about 2 % code for proteins. However, there are about one to two million protein entities. This is primarily due to alternative splicing and post-translational modifications (PTMs). Identifying all these modifications in one proteome at a particular time point during development or during the transition from normal to ...
Armand G, Ngounou Wetie +2 more
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[Post-translational modification (PTM) bioinformatics in China: progresses and perspectives].
Yi chuan = Hereditas, 2015Post-translational modifications (PTMs) are essential for regulating conformational changes, activities and functions of proteins, and are involved in almost all cellular pathways and processes. Identification of protein PTMs is the basis for understanding cellular and molecular mechanisms.
Ze-xian, Liu +13 more
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PROTEOMICS, 2013
Mass spectrometry (MS) analysis of peptides carrying post‐translational modifications is challenging due to the instability of some modifications during MS analysis. However, glycopeptides as well as acetylated, methylated and other modified peptides release specific fragment ions during CID (collision‐induced dissociation) and HCD
Nanni, Paolo +5 more
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Mass spectrometry (MS) analysis of peptides carrying post‐translational modifications is challenging due to the instability of some modifications during MS analysis. However, glycopeptides as well as acetylated, methylated and other modified peptides release specific fragment ions during CID (collision‐induced dissociation) and HCD
Nanni, Paolo +5 more
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International Journal of Biological Macromolecules
Horticultural crops are extensively cultivated throughout the world as crucial economical crops, encompassing fruits, vegetables, ornamentals, medicinal and beverage plants, for purposes such as food supply, special nutrition provision, medical application or aesthetic enjoyment.
Zhongxing, Zhang +6 more
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Horticultural crops are extensively cultivated throughout the world as crucial economical crops, encompassing fruits, vegetables, ornamentals, medicinal and beverage plants, for purposes such as food supply, special nutrition provision, medical application or aesthetic enjoyment.
Zhongxing, Zhang +6 more
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Nanopore characterisation of Post-Translational Modifications (PTMs) on protein concatemers
Proteins exist as diverse proteoforms that carry distinct combinations of posttranslational modifications (PTMs). Reading these states at the single-molecule level would reveal biological phenomena inaccessible to genomics and transcriptomics. This thesis develops nanopore-based strategies that move towards full-length, residue-level proteoform ...openaire +1 more source
The role of ral signaling and post translational modifications (PTMs) of Ras in cancer
Genome Instability & Disease, 2022Mohammad Reza Zinatizadeh +4 more
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PTM-dCN: Latent Space Control for Post-Translational Modification–Aware Protein Design
A bstract Post-translational modifications (PTMs) are critical for protein function, yet their precise design by harnessing site specific information derived from native proteins remains challenging.Sitao Zhang +3 more
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2012
Post-translationale Modifikationen (PTMs) wurden während der letzten Jahrzehnte ausgiebig mit verschiedensten Methoden erforscht. Sie sind Bestandteil einer Vielzahl wichtiger Zellprozesse, einschließlich verschiedener Signalweiterleitungs-, Regulations- und Lokalisierungsvorgänge. PTMs ermöglichen die vorwiegend reversible Veränderung von Aminosäuren,
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Post-translationale Modifikationen (PTMs) wurden während der letzten Jahrzehnte ausgiebig mit verschiedensten Methoden erforscht. Sie sind Bestandteil einer Vielzahl wichtiger Zellprozesse, einschließlich verschiedener Signalweiterleitungs-, Regulations- und Lokalisierungsvorgänge. PTMs ermöglichen die vorwiegend reversible Veränderung von Aminosäuren,
openaire +1 more source