Results 201 to 210 of about 5,850,387 (280)

Post-Translational Modifications in Traumatic Brain Injury: Decoding the Proteomic Landscape and Molecular Mechanisms of Secondary Injury. [PDF]

FASEB J
Shen P, Li L, Zhang Z, Zong L.
europepmc   +1 more source

Mapping Allergen B‐ and T‐Cell Epitopes: Technological Advances and Their Role in Precision Allergy Therapy

Allergy, EarlyView.
ABSTRACT Allergic diseases arise from aberrant immune recognition of otherwise harmless environmental proteins and are driven by epitope‐specific interactions between allergens and the adaptive immune system. Although component‐resolved diagnostics have improved molecular characterisation of sensitization, they remain limited to whole‐allergen ...
Mark Møiniche, Josefine Corneliussen, Kristoffer H. Johansen, Alexandre Ruiz‐Carrasco, Caroline Paulsen, Yuchen Li, Carolina Barra, Sandhya Bangaru, Monica L. Fernández‐Quintero, Ewa Bartko, Lars Blom, Esperanza Rivera‐de‐Torre   +11 more
wiley   +1 more source

Propionic acidemia as a framework for understanding the impact of disturbed propionyl-CoA on histone modifications. [PDF]

Biochem Soc Trans
Swietach P, Gill EK, Holzner LMW.
europepmc   +1 more source

Spatiotemporal Expression of ARRDC5 in Mammalian Spermatogenesis

Andrology, EarlyView.
ABSTRACT Background Spermiogenesis is the final phase of sperm development during which haploid round spermatids transform into specialized spermatozoa and occurs across distinct stages of sperm production in the seminiferous epithelium. Abnormalities in this process lead to malformations and an inability of sperm to fertilize eggs.
LeeLa D. Robinson, Jon M. Oatley
wiley   +1 more source

Metabolite-driven protein modifications in immune signaling: from established principles to emerging pyruvylation. [PDF]

Front Immunol
Zhang Z, Xu M, Zhang S, Zhang Z, Zhang H, Wang Z, Zhu M, Zhao H.   +7 more
europepmc   +1 more source

Cryopreservation Disrupts TRIM21‐Mediated AKAP3 Ubiquitination and Triggers Stress Granule Formation in Human Sperm

Andrology, EarlyView.
ABSTRACT Background Sperm cryopreservation causes cryodamage, but the roles of posttranslational modifications (PTMs) and stress granules (SGs) in this process remain unclear. Objectives To investigate the molecular mechanism of cryodamage via the TRIM21–AKAP3 axis, PTMs, and SGs.
Yan Wang, Huizhong Xu, Wenhong Lu, Yinghao Wang, Jin Ma, Chengyao Ma, Xiangming Yan, Longlong Fu, Haitao Lv, Ying Liu   +9 more
wiley   +1 more source

Post-translational control of MAVS signaling: linking mitochondrial antiviral immunity to metabolic and cellular stress contexts. [PDF]

Front Physiol
Morimoto N, Okazaki T.
europepmc   +1 more source

Proteomic Sex Estimation From Embedded Tooth Enamel

Archaeometry, EarlyView.
ABSTRACT Teeth hold insights into childhood diet, health and demography—including chromosomal sex. Proteomic analysis can detect peptide biomarkers from amelogenin genes encoded on X and Y chromosomes, allowing sex estimation. Embedding resins, necessary for thin sectioning teeth, can damage analytical systems, preventing proteomic analysis. We present
E. L. Sudron, G. Parker, T. Buonasera, K. Burk, C. Canzonieri, J. W. Eerkens, M. Ehlers, D. Loo‐Oey, C. Matheson, M. Salemi, C. Zimmer, T. M. Smith   +11 more
wiley   +1 more source

Crosstalk between ubiquitination and other post-translational modifications in cardiovascular diseases. [PDF]

iScience
Yan Y, Li Z, Xiao T.
europepmc   +1 more source

Artificial intelligence–based 3D segmentation of tangle‐associated TDP‐43 in neurodegeneration

Brain Pathology, EarlyView.
Multiplex immunostaining of anti‐phosphorylated TDP‐43, tau (AT8, pS396, TauC3, MN423, GT38), and Thioflavin S combined with AI‐based object recognition, reconstruction, and TAT maturation analysis pipeline in limbic regions revealed that distinct aggregation and tangle maturation patterns underscored region‐specific dynamics in the neurodegenerative ...
Gokhan Uruk, Hossam Youssef, Rodolfo G. Gatto, Nadia Hossain, Jennifer L. Whitwell, Robert R. Reichard, Keith A. Josephs   +6 more
wiley   +1 more source