Results 241 to 250 of about 85,477 (330)

Structural Study of a Peptide Epitope Bearing Multiple Post-Translational Modifications in Rheumatoid Arthritis. [PDF]

Int J Mol Sci
Gómara MJ, García-Moreno C, Bárcenas O, Castellanos-Moreira R, Sarmiento JC, Crehuet R, Pérez Y, Sanmartí R, Haro I.   +8 more
europepmc   +1 more source

FLASHApp: Interactive Data Analysis and Visualization for Top‐Down Proteomics

PROTEOMICS, EarlyView.
ABSTRACT Top‐down proteomics (TDP) is increasingly being applied in proteoform‐resolved biomedical and clinical research. However, the complexity of TDP data demands flexible visualization tools integrated with analysis workflows to streamline interpretation and validation. Existing tools lack adaptability and interactivity, often requiring researchers
Tom David Müller, Jihyung Kim, Andrew Almaguer, Ayesha Feroz, Jaekwan Kim, Axel Walter, Wonhyeuk Jung, Oliver Kohlbacher, Kyowon Jeong   +8 more
wiley   +1 more source

Characterization of Cytokine Treatment on Human Pancreatic Islets by Top‐Down Proteomics

PROTEOMICS, EarlyView.
ABSTRACT Type 1 diabetes (T1D) results from autoimmune‐mediated destruction of insulin‐producing β cells in the pancreatic islet. This process is modulated by pro‐inflammatory cytokine signaling, which has been previously shown to alter protein expression in ex vivo islets.
Ashley N. Ives, Tyler J. Sagendorf, Lorenz Nierves, Tai‐Tu Lin, Ercument Dirice, Rohit N. Kulkarni, Ljiljana Paša‐Tolić, Wei‐Jun Qian, James M. Fulcher   +8 more
wiley   +1 more source

Post-translational governance of NF-κB in cancer immunity: mechanisms and therapeutic horizons. [PDF]

Front Immunol
Hong Y, Fu Y, Long Q.
europepmc   +1 more source

Chemoproteomic Profiling of Reactive Cysteines in Response to Oxidative Stress Induced by 6‐Hydroxydopamine

PROTEOMICS, EarlyView.
ABSTRACT Although oxidative stress is a well‐established driver of neurodegeneration, it remains poorly understood as to how the global cysteine (Cys) proteome is remodeled under oxidative stress conditions. Proteins with aberrantly modified cysteines in response to oxidative stress can induce and exacerbate neurodegeneration, contributing to disorders
Rayan Murtada, Chiho Kim, Xu‐dong Wang, Youkai Yang, Yonghao Yu   +4 more
wiley   +1 more source

Editorial: Post-transcriptional modifications in cancer immunity and immunotherapy. [PDF]

Front Immunol
Wei G, Zhou Y, Yue T, Zhang D.
europepmc   +1 more source

Computational Approaches for Pathway‐Centric Analysis of Protein Post‐Translational Modifications

PROTEOMICS, EarlyView.
ABSTRACT Protein function is dynamically modulated by post‐translational modifications (PTMs). Many different types of PTMs can nowadays be identified and quantified at a large scale using mass spectrometry. It is well known that many PTMs have an effect on protein function and cellular processes, and they should be studied not in isolation, but in the
Julian Müller, Bernhard Kuster, Matthew The   +2 more
wiley   +1 more source

Proteomics Insights Into Lysosome Biogenesis and Maturation

PROTEOMICS, EarlyView.
ABSTRACT Lysosomes constitute the main degradative organelle of most eukaryotic cells and are capable of breaking down a wide spectrum of biomolecules, including proteins, lipids, glycans, and DNA/RNA. They play crucial roles in the regulation of cellular homeostasis, acting as metabolic signaling centers for the correlation of nutrient availability ...
Katharina Hirn, Sofía Fajardo‐Callejón, Dominic Winter   +2 more
wiley   +1 more source

Reactive oxygen species-post translational modifications-central carbon metabolism regulatory loop: coordination of redox homeostasis and carbon flux allocation in plants under abiotic stress. [PDF]

Front Plant Sci
Bao L, Wang W, Li M, Liu J, Liu J, Alifu G, Wang D, Liang X, Mao T, Zhai Y.   +9 more
europepmc   +1 more source

Artificial Intelligence and the Evolving Landscape of Immunopeptidomics

PROTEOMICS – Clinical Applications, EarlyView.
ABSTRACT Background Immunopeptidomics is the large‐scale study of peptides presented by major histocompatibility complex (MHC) molecules and plays a central role in neoantigen discovery and cancer immunotherapy. However, the complexity of mass spectrometry data, the diversity of peptide sources, and variability in immune responses present major ...
Thanh Hoa Vo, Edel McNeela, Orla O'Donovan, Sweta Rani, Jai Prakash Mehta   +4 more
wiley   +1 more source