Results 241 to 250 of about 76,851 (293)

Acyl post-translational modification of proteins by metabolites in cancer cells. [PDF]

Cell Death Discov
Wang X, Guo Y, Fu Y, Zhang C, Chen W, Tang X, Yu Y, Chen Y, Ding G, Zhang J.   +9 more
europepmc   +1 more source

Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang, Minqiao Lu, Yi Zhang, Jiangwen Ma, Ying Hu   +4 more
wiley   +1 more source

Regulatory Mechanisms and Therapeutic Targeting of PD-L1 Trafficking and Stability in Cancer Immunotherapy. [PDF]

Cancers (Basel)
Mani M, Park JW, Martin TFJ.
europepmc   +1 more source

Oxidative Stress in Antigen Processing and Presentation

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang, Yaying Zhang, Xiaojun Liu, Peng Miao, Wenbing Pu, Shanshan Liu, Jing Zhang, Yuan Tian, Guobo Shen, Na Xie   +9 more
wiley   +1 more source

Comparison of enriched charge variants from different anti-CD3 bispecific antibodies reveals differential susceptibility of each bispecific arm to post-translational modification. [PDF]

Protein Sci
Nguyen JB, Liu S, Howie DA, Oberholtzer ZR, Ong ET, Rao R, Prinston JE, Dikiy I, Wu J, Wu Z, Zhao Y, Li M, Molden R, Molina G, Provoncha K, Sandu C, Qiu H, Li N, Matousek W, Rosconi MP, Pyles EA.   +20 more
europepmc   +1 more source

The SUV39 Family of H3K9 Methyltransferases in Skeletal Muscle Stem Cells

FASEB BioAdvances, Volume 7, Issue 6, June 2025.
The SUV39 family members are well known for methylating the Lysine 9 of the histone H3 (H3K9) in order to compact the chromatin and contributing to gene repression. We describe their active role in proliferating and differentiating muscle stem cells, how they prevent from inflammation and fibrosis during muscle regeneration and the future avenues ...
Pauline Garcia, Slimane Ait‐Si‐Ali, Fabien Le Grand   +2 more
wiley   +1 more source

One-Pot Total Synthesis of a Post-translationally Modified Max Transcription Factor Sheds Light on Ser-Phosphorylation and Lys-Acetylation Crosstalk in DNA Binding. [PDF]

Org Lett
Nithun RV, Khoury S, Jbara M.
europepmc   +1 more source

Diabetes Advances Cardiomyocyte Senescence Through Interfering Rnd3 Expression and Function

Aging Cell, Volume 24, Issue 6, June 2025.
Diabetes‐induced upregulation of miR‐103a‐3p suppresses Rnd3 expression in cardiomyocytes, thereby promoting the senescence‐associated secretory phenotype (SASP) through activation of the STAT3 signaling pathway, mediated by UPS‐induced degradation of p‐STAT3.
Linxu Wu, Xinglin Zhu, Shanshan Pan, Yan Chen, Cai Luo, Yangyang Zhao, Jingci Xing, Kaijia Shi, Shuya Zhang, Jiaqi Li, Jinxuan Chai, Xuebin Ling, Jianmin Qiu, Yan Wang, Zhihua Shen, Wei Jie, Junli Guo   +16 more
wiley   +1 more source

Versatile roles of disordered transcription factor effector domains in transcriptional regulation

The FEBS Journal, Volume 292, Issue 12, Page 3014-3033, June 2025.
Disordered effector domains (EDs) of transcription factors (TFs) play versatile roles in transcriptional regulation. These include mediating protein–protein interactions with protein complexes like, facilitating condensate formation to enhance transcriptional efficiency, modulating DNA‐binding specificity through genome scanning, and serving as hubs ...
Rhea R. Datta, Dilan Akdogan, Elif B. Tezcan, Pinar Onal   +3 more
wiley   +1 more source

Protein modifications in hepatic ischemia-reperfusion injury: molecular mechanisms and targeted therapy. [PDF]

Front Immunol
Zhao X, Li Q, Zhu X, Jiao Y, Yang H, Feng J.   +5 more
europepmc   +1 more source