Frontiers in Molecular Neuroscience, 2021 Gene expression and translation have been extensively studied in human post-mortem brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs) have received less attention despite their implication by unbiased genetic ...
Melanie J. Grubisha +3 more
doaj +1 more source
Recent advances in malaria genomics and epigenomics [PDF]
, 2016 Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian +2 more
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Thiol redox proteomics: Characterization of thiol‐based post‐translational modifications
Proteomics, 2023 Redox post‐translational modifications on cysteine thiols (redox PTMs) have profound effects on protein structure and function, thus enabling regulation of various biological processes.
Xiaolu Li +3 more
semanticscholar +1 more source
PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data [PDF]
, 2014 Interactions among transcriptional factors (TFs), cofactors and other proteins or enzymes can affect transcriptional regulatory capabilities of eukaryotic organisms. Post-translational modifications (PTMs) cooperate with TFs and epigenetic alterations to
Boheler, KR +8 more
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Post-Translational Modifications in Histones and Their Role in Abiotic Stress Tolerance in Plants
Proteomes, 2023 Abiotic stresses profoundly alter plant growth and development, resulting in yield losses. Plants have evolved adaptive mechanisms to combat these challenges, triggering intricate molecular responses to maintain tissue hydration and temperature stability
Madhvi Sharma +5 more
semanticscholar +1 more source
PTM-ssMP: A Web Server for Predicting Different Types of Post-translational Modification Sites Using Novel Site-specific Modification Profile [PDF]
International Journal of Biological Sciences, 2018 Protein post-translational modifications (PTMs) are chemical modifications of a protein after its translation. Owing to its play an important role in deep understanding of various biological processes and the development of effective drugs, PTM site prediction have become a hot topic in bioinformatics.
Yu Liu +4 more
openalex +4 more sources
Roles of Post-translational Modifications in Spinocerebellar Ataxias
Frontiers in Cellular Neuroscience, 2018 Post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, SUMOylation, etc., of proteins can modulate protein properties such as intracellular distribution, activity, stability, aggregation, and interactions ...
Linlin Wan +14 more
doaj +1 more source
Frontiers in Microbiology, 2020 Throughout various stages of its life cycle, influenza A virus relies heavily on host cellular machinery, including the post-translational modifications (PTMs) system.
Jiao Hu +8 more
doaj +1 more source
Identification of N-terminal protein acetylation and arginine methylation of the voltage-gated sodium channel in end-stage heart failure human heart [PDF]
, 2014 The α subunit of the cardiac voltage-gated sodium channel, Naᵥ1.5, provides the rapid sodium inward current that initiates cardiomyocyte action potentials.
Batlle, Montserrat +13 more
core +1 more source
Alpha synuclein post translational modifications: potential targets for Parkinson’s disease therapy?
Frontiers in Molecular Neuroscience, 2023 Parkinson’s disease (PD) is the most common neurodegenerative disorder with motor symptoms. The neuropathological alterations characterizing the brain of patients with PD include the loss of dopaminergic neurons of the nigrostriatal system and the ...
Viviana Brembati +3 more
semanticscholar +1 more source