Results 61 to 70 of about 76,851 (293)

Evolution and functional cross‐talk of protein post‐translational modifications

Molecular Systems Biology, 2013
Protein post‐translational modifications (PTMs) allow the cell to regulate protein activity and play a crucial role in the response to changes in external conditions or internal states.
Pedro Beltrao, Peer Bork, Nevan J. Krogan, Vera van Noort   +3 more
doaj   +1 more source

Role of Post-translational Modifications in Influenza A Virus Life Cycle and Host Innate Immune Response

Frontiers in Microbiology, 2020
Throughout various stages of its life cycle, influenza A virus relies heavily on host cellular machinery, including the post-translational modifications (PTMs) system.
Jiao Hu, Jiao Hu, Jiao Hu, Lei Zhang, Lei Zhang, Lei Zhang, Xiufan Liu, Xiufan Liu, Xiufan Liu   +8 more
doaj   +1 more source

Role of non-canonical post-translational modifications in gastrointestinal tumors

Cancer Cell International, 2023
Post-translational modifications (PTMs) of proteins contribute to the occurrence and development of tumors. Previous studies have suggested that canonical PTMs such as ubiquitination, glycosylation, and phosphorylation are closely implicated in different
Yihong Liu, Jingwei Liu, Na Peng, Shuangshuang Hai, Shen Zhang, Haibo Zhao, Weixin Liu   +6 more
doaj   +1 more source

Control of protein stability by post-translational modifications

Nature Communications, 2023
Here the authors summarize current knowledge of the regulation of protein stability by various post-translational modifications (PTMs) including methylation and phosphorylation.
Ji Min Lee, Henrik M. Hammarén, Mikhail M. Savitski, Sung Hee Baek   +3 more
doaj   +1 more source

How many human proteoforms are there? [PDF]

, 2018
Despite decades of accumulated knowledge about proteins and their post-translational modifications (PTMs), numerous questions remain regarding their molecular composition and biological function. One of the most fundamental queries is the extent to which
Aebersold, Ruedi, Agar, Jeffrey N, Amster, I Jonathan, Baker, Mark S, Bertozzi, Carolyn R, Boja, Emily S, Costello, Catherine E, Cravatt, Benjamin F, Fenselau, Catherine, Garcia, Benjamin A, Ge, Ying, Gunawardena, Jeremy, Hendrickson, Ronald C, Hergenrother, Paul J, Huber, Christian G, Ivanov, Alexander R, Jensen, Ole N, Jewett, Michael C, Kelleher, Neil L, Kiessling, Laura L, Krogan, Nevan J, Larsen, Martin R, Loo, Joseph A, Lundberg, Emma, MacCoss, Michael J, Mallick, Parag, Mootha, Vamsi K, Mrksich, Milan, Muir, Tom W, Ogorzalek Loo, Rachel R, Patrie, Steven M, Pesavento, James J, Pitteri, Sharon J, Rodriguez, Henry, Saghatelian, Alan, Sandoval, Wendy, Schlüter, Hartmut, Sechi, Salvatore, Slavoff, Sarah A, Smith, Lloyd M, Snyder, Michael P, Thomas, Paul M, Uhlén, Mathias, Van Eyk, Jennifer E, Vidal, Marc, Walt, David R, White, Forest M, Williams, Evan R, Wohlschlager, Therese, Wysocki, Vicki H, Yates, Nathan A, Young, Nicolas L, Zhang, Bing   +52 more
core   +1 more source

Cysteine post-translational modifications: ten years from chemical proteomics to bioinformatics [PDF]

arXiv, 2021
As the only thiol-bearing amino acid, cysteine (Cys) residues in proteins have the reactive thiol side chain, which is susceptible to a series of post-translational modifications (PTMs). These PTMs participate in a wide range of biological activities including the alteration of enzymatic reactions, protein-protein interactions and protein stability ...
arxiv  

Quantifying homologous proteins and proteoforms [PDF]

Molecular & Cellular Proteomics, 2018, 2017
Many proteoforms - arising from alternative splicing, post-translational modifications (PTMs), or paralogous genes - have distinct biological functions, such as histone PTM proteoforms. However, their quantification by existing bottom-up mass-spectrometry (MS) methods is undermined by peptide-specific biases.
arxiv   +1 more source

Identifying Protein Interactions with Histone Peptides Using Bio-layer Interferometry

Bio-Protocol, 2018
Histone post-translational modifications (PTMs) regulate numerous cellular processes, including gene transcription, cell division, and DNA damage repair. Most histone PTMs affect the recruitment or exclusion of reader proteins from chromatin.
Bingbing Ren, Ahmed Sayed, Hwei Tan, Yu Mok, Ee Chen   +4 more
doaj   +1 more source

Identification of ultramodified proteins using top-down tandem mass spectra [PDF]

, 2013
Post-translational modifications (PTMs) play an important role in various biological processes through changing protein structure and function.
Hengel, Shawna, Liu, Xiaowen, Pasa-Tolić, Ljiljana, Pevzner, Pavel A., Tolić, Nikola, Wu, Si   +5 more
core   +1 more source

Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity

Nature Communications, 2016
Many biopharmaceuticals exhibit mixed heterogeneity in their post-translational modifications (PTMs) that are essential for their function. Here the authors use a combination of mass spectrometry techniques to analyse human erythropoietin (EPO) and ...
Yang Yang, Fan Liu, Vojtech Franc, Liem Andhyk Halim, Huub Schellekens, Albert J. R. Heck   +5 more
doaj   +1 more source