Results 81 to 90 of about 41,962 (282)

Role of enhancer of zeste homolog 2 polycomb protein and its significance in tumor progression and cell differentiation [PDF]

, 2013
Epigenetics is a branch of genetics that focuses on the heritable changes of DNA or associated proteins, other than DNA sequence variations, which carry information content during cell division [1,2].
Bagella, Luigi Marco, Marchesi, Irene
core   +2 more sources

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

The role of histone post-translational modifications in cancer and cancer immunity: functions, mechanisms and therapeutic implications

Frontiers in Immunology
Histones play crucial roles in both promoting and repressing gene expression, primarily regulated through post-translational modifications (PTMs) at specific amino acid residues.
Xiaohong Duan, Xiaohong Duan, Xiaohong Duan, Zhiyao Xing, Zhiyao Xing, Zhiyao Xing, Lu Qiao, Shan Qin, Xuejing Zhao, Yanhua Gong, Yanhua Gong, Yanhua Gong, Xueren Li, Xueren Li   +13 more
doaj   +1 more source

Site-selective protein-modification chemistry for basic biology and drug development. [PDF]

, 2015
Nature has produced intricate machinery to covalently diversify the structure of proteins after their synthesis in the ribosome. In an attempt to mimic nature, chemists have developed a large set of reactions that enable post-expression modification of ...
A Perols, A Sachdeva, AJ Keefe, B Fierz, B-Q Shen, BM Zeglis, C Chatterjee, C Goodman, CD Spicer, CT Walsh, D Schumacher, DP Nguyen, E Arbely, EM Pelegri-O'Day, EM Sletten, F Casadio, F Li, F Tian, Filipa P. da Cruz, G Pasut, GJL Bernardes, Gonçalo J. L. Bernardes, H Cho, H Neumann, HF Gaertner, HP Hemantha, J Li, J Li, J Madrzak, J Xie, J-M Kee, JI MacDonald, JL Seitchik, JM Chalker, JM Chalker, JM Chalker, JM Gilmore, JR Junutula, JY Axup, K Lang, K Lang, K Wang, KJ Hamblett, KP Chooi, L Davis, LN Tumey, M Rashidian, M Steiner, M Yang, MD Simon, N Stephanopoulos, N Toda, Nikolaus Krall, NS Beckley, Omar Boutureira, P Agarwal, P Dawson, P Wang, PM Drake, PMSD Cal, R Huang, R Rossin, R Serwa, RM Versteegen, RP Lyon, RVJ Chari, RVJ Chari, S Arur, S Tyagi, S Virdee, S Virdee, S Zheng, SI van Kasteren, SNS Alconcel, T Burckstummer, T Schneider, TS Elliott, TW Muir, W Liu   +78 more
core   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks [PDF]

, 2018
Integrated multiomics network analysis reveals signaling profiles in lung cancer.
Clark, Neil R., Comb, Michael, Cook, William, Foltz, Lauren, Gaiser, Jeremiah, Grimes, Mark, Hall, Benjamin, Hornbeck, Peter, Lachmann, Alexander, Levy, Tyler, Ma’ayan, Avi, Rikova, Klarisa, Smirnova, Ekaterina, Wheeler, Travis, Zhang, Bin   +14 more
core   +1 more source

Mammalian Proteome Profiling Reveals Readers and Antireaders of Strand‐Symmetric and ‐Asymmetric 5‐Hydroxymethylcytosine‐Modifications in DNA

Advanced Science, EarlyView.
ABSTRACT The cytosine (C) modifications 5‐methylcytosine (mC) and 5‐hydroxymethylcytosine (hmC) are central regulatory elements of mammalian genomes. Both marks occur in double‐stranded DNA in either strand‐symmetric or ‐asymmetric fashion, but it is still poorly understood how this symmetry information is selectively read out by the nuclear proteome ...
Lena Engelhard, Zeyneb Vildan Cakil, Marlon S. Zambrano‐Mila, Simone Eppmann, Tye Gonzalez, Rasmus Linser, Petra Janning, Sidney Becker, Daniel Summerer   +8 more
wiley   +1 more source

Distinct types of protein modifications in diabetic endothelial dysfunction

Cardiovascular Diabetology
Diabetes mellitus is a metabolic disorder characterized by persistent hyperglycemia. Chronic diabetes mellitus may contribute to endothelial dysfunction and result in various conditions such as diabetic retinopathy, diabetic nephropathy, neuropathy ...
Qianyou Zhou, Xintong Ge, Zhaojing Chen, Danyi Cao, Yun Chen, Jiahai Shi, Guoliang Meng   +6 more
doaj   +1 more source

The novel E3 ligase of PPAR?? TRIM25 regulates adipocyte differentiation [PDF]

, 2018
Department of Biological SciencesPeroxisome proliferator-activated receptor ?? (PPAR??) is a ligand-dependent transcription factor which regulates glucose homeostasis and adipocyte differentiation.
Lee, Jae Min
core  

Conformational Dynamics and Thermal Cones of C-terminal Tubulin Tails in Neuronal Microtubules [PDF]

, 2007
In this paper we present a model for estimation of the C-terminal tubulin tail (CTT) dynamics in cytoskeletal microtubules of nerve cells. We show that the screened Coulomb interaction between a target CTT and the negatively charged microtubule surface ...
Georgiev, Danko, Glazebrook, James
core   +1 more source