Results 171 to 180 of about 77,986 (211)

Inhibition of Endogenous Phosphatase in a Postsynaptic Density Fraction Allows Extensive Phosphorylation of the Major Postsynaptic Density Protein

Journal of Neurochemistry, 1993
Abstract: The major postsynaptic density protein, proposed to be a calcium/calmodulin‐dependent protein kinase, becomes phosphorylated when a postsynaptic density preparation from rat cerebral cortex is incubated in medium containing calcium and calmodulin. Upon longer incubation, however, the level of phosphorylation declines, suggesting the presence
Ayse Dosemeci, Thomas S Reese
exaly   +3 more sources

Postmortem Accumulation of Tubulin in Postsynaptic Density Preparations

Journal of Neurochemistry, 1982
Abstract: Postsynaptic density (PSD) preparations isolated from canine cerebral cortex that had been left at 0–37°C for various times were found to become enriched in two bands in a time‐ but not temperature‐dependent manner. The two bands were identified as tubulin subunits by gel mobility and immunology.
R K Carlin, D J Grab, Philip Siekevitz
exaly   +3 more sources

Phosphoproteins in Postsynaptic Densities

1982
Publisher Summary The postsynaptic density (PSD) is a dense submembranous filamentous array located behind and in intimate contact with the postsynaptic membrane. PSDs have been isolated from synaptosomal plasma membranes and synaptosomes using various detergents.
R S, Cohen, R K, Carlin, D J, Grab, P, Siekevitz   +3 more
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The postsynaptic density

Cell and Tissue Research, 2006
Glutamatergic synapses in the central nervous system are characterized by an electron-dense web underneath the postsynaptic membrane; this web is called the postsynaptic density (PSD). PSDs are composed of a dense network of several hundred proteins, creating a macromolecular complex that serves a wide range of functions. Prominent PSD proteins such as
openaire   +2 more sources

Scaffold Proteins at the Postsynaptic Density

2012
Scaffold proteins are abundant and essential components of the postsynaptic density (PSD). They play a major role in many synaptic functions including the trafficking, anchoring, and clustering of glutamate receptors and adhesion molecules. Moreover, they link postsynaptic receptors with their downstream signaling proteins and regulate the dynamics of ...
Verpelli Chiara, Schmeisser Michael J, Sala Carlo, Boeckers Tobias Maria   +3 more
openaire   +3 more sources

The Effects of Detergents on the Composition of Postsynaptic Densities

Journal of Neurochemistry, 1984
Abstract: A method of purifying postsynaptic densities (PSD) of Cohen et al. (1977) has been modified, primarily by the substitution of octyl glucoside as the detergent used to solubilize synaptosomal fractions. Subsequent extraction with other detergents resulted in the selective removal of specific polypeptides.
R A, Somerville, P A, Merz, R I, Carp
openaire   +2 more sources

The postsynaptic density

Trends in Neurosciences, 1981
Abstract Synapses are not only sites of intense physiological activity, but also areas of complex and intriguing morphological specialization. Among the features seen with the electron microscope are a set of structures attached to the junctional membranes of brain synapses.
openaire   +1 more source

Building the Postsynaptic Density

Science's STKE, 2006
The postsynaptic density (PSD) is a large and dynamic protein complex on the postsynaptic side of neural synapses that helps to communicate incoming signals to cytoplasmic targets. Shank proteins are located deep in the PSD and may be involved in organizing the structure of the complex. Baron et al.
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The postsynaptic density at glutamatergic synapses

Trends in Neurosciences, 1997
The postsynaptic density (PSD) is a tiny, amorphous structure located beneath the postsynaptic membrane of synapses in the CNS. Until recently, the molecular composition and function of the PSD were mostly matters of speculation. With the advent of powerful new microchemical tools and molecular-genetic methods, three new classes of proteins have been ...
openaire   +3 more sources

In vivo phosphorylation of postsynaptic density proteins

Neuroscience, 1984
In vivo protein phosphorylation was examined in postsynaptic density-enriched fractions isolated from rat brain. In vivo phosphorylation was carried out by injecting rats intraventricularly with [32P]orthophosphate followed by isolation of postsynaptic densities from pooled cerebral cortices.
R F, Berman, J P, Hullihan, W J, Kinnier, J E, Wilson   +3 more
openaire   +2 more sources