Results 181 to 190 of about 77,986 (211)

Structural organization of filamentous proteins in postsynaptic density

Biochemistry, 1983
Actin is one of the major protein constituents of the postsynaptic density (PSD), a characteristic structural entity subjacent to the postsynaptic membrane in excitatory synapses of the vertebrate central nervous system. In isolated purified PSD preparations, it is present to the extent of 29 +/- 2 micrograms/mg of total protein, 90% of which is in the
N, Ratner, H R, Mahler
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SAP97 concentrates at the postsynaptic density in cerebral cortex

European Journal of Neuroscience, 2000
AbstractSAP97, a PDZ‐containing protein, is reported to concentrate in axon terminals, where its function remains unknown. Using highly specific new antibodies, we show that SAP97 in rat cerebral cortex is associated with heteromeric AMPA receptors via a selective biochemical interaction between SAP97 and the GluR1 subunit.
J G, Valtschanoff, A, Burette, M A, Davare, A S, Leonard, J W, Hell, R J, Weinberg   +5 more
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Effect of calpain on the composition and structure of postsynaptic densities

Synapse, 1995
AbstractEndogenous calcium‐activated proteases, the calpains, are thought to play a role in the regulation of postsynaptic function. Here we characterize some biochemical and morphological effects of calpain on isolated postsynaptic densities (PSDs). When a PSD preparation from rat forebrain was treated with exogenous calpain, many proteins, including ...
A, Dosemeci, T S, Reese
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Scaffold Proteins in the Postsynaptic Density

2008
Many intractable neurological and mental diseases, including epilepsy, depression, and schizophrenia, are believed to result, in part, from derangements of regulation of synaptic transmission in the brain. For this reason, much effort has been made to discover how the delicate mechanisms of signal transduction at synapses lead to modification of ...
Kennedy, Mary B., Marcora, Edoardo, Carlisle, Holly J.   +2 more
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Postsynaptic Density/Architecture at Excitatory Synapses

2009
At excitatory synapses of the central nervous system, the postsynaptic density (PSD), a specialized structure underneath the postsynaptic membrane, controls the reception and integration of synaptic signals. The PSD functions as an extended protein assembly connecting integral membrane proteins (e.g., glutamate-gated ion channels) with cytoskeletal ...
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Proteomic Analysis of the Postsynaptic Density

2010
The postsynaptic density (PSD) is a large protein complex lining the postsynaptic membrane with an average mass around 1 million KDa. The structure appears to be an organized array containing neurotransmitter receptors and signal transduction molecules held together by specialized scaffold proteins.
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Molecular characterization of the postsynaptic density

1996
The postsynaptic density (PSD) is an electron dense structure just beneath the postsynaptic membrane. Several functions have been proposed for the PSD including regulating receptor number and clustering, anchoring signal transduction molecules at the synapse and mediating adhesion between the presynaptic and postsynaptic membranes.
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THE PRESENCE AND FUNCTIONS OF CALMODULIN IN THE POSTSYNAPTIC DENSITY

Annals of the New York Academy of Sciences, 1980
D J, Grab, R K, Carlin, P, Siekevitz
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Reconstituted Postsynaptic Density as a Molecular Platform for Understanding Synapse Formation and Plasticity

Cell, 2018
Menglong Zeng, Xudong Chen, Dongshi Guan   +2 more
exaly  

Tissue-type plasminogen activator protects the postsynaptic density in the ischemic brain

Journal of Cerebral Blood Flow and Metabolism, 2018
Valerie Jeanneret, Juan Pablo Ospina, Ariel Diaz   +2 more
exaly