Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Background: This study aims to identify genes with a high likelihood of genetic variation, significant expression differences, and prognostic implications in colorectal cancer (CRC) patients. The research also seeks to investigate the role and mechanisms of key genes in CRC through the analysis of health information data and a combination of ...
Kaobin Ouyang +3 more
wiley +1 more source
Conformational Rearrangement of Fission DSPs
BioEssays, EarlyView.Assembly properties of fission DSPs. Fission DSPs exist in a dynamic equilibrium of oligomer states in the cytosol, where they must be activated by partner proteins or lipid to induce assembly, and upon GTP hydrolysis, constriction. ABSTRACT Dynamin superfamily proteins (DSPs) are large GTPases that play crucial roles in membrane remodeling processes ...
Anelise N. Hutson +2 more
wiley +1 more source
Impact of Dendritic Spine Loss on Excitability of Hippocampal CA1 Pyramidal Neurons: A Computational Study of Early Alzheimer Disease. [PDF]
HippocampusTian C, Reyes I, Johnson A, Masurkar AV.
europepmc +1 more source
Valerian Extract Ze 911 Inhibits Postsynaptic Potentials by Activation of Adenosine A1 Receptors in Rat Cortical Neurons [PDF]
, 2006 Z Vissiennon +4 more
openalex +1 more source
Fusion Pores as Regulators of Quantal Size and Cellular Physiology
BioEssays, EarlyView.During regulated exocytosis, membrane fusion regulatory factors act directly on SNAREs and membrane lipids to control fusion pore dynamics. This, in turn, leads to a differential amount of cargo release (referred to in this article as “quantal size”) across various cell types, thereby triggering distinct physiological cues.
Bhavya R. Bhaskar +3 more
wiley +1 more source
Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing. [PDF]
Nat NeurosciTriplett MA +5 more
europepmc +1 more source
Correlation transfer for integrate and fire models with finite postsynaptic potentials [PDF]
, 2010 Robert Rosenbaum, Krešimir Josić́
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Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives
BioEssays, EarlyView.Breathing is typically automatic, ensuring homeostasis, but it is also shaped by emotion, behavior, and volition. This review synthesizes our current understanding of the flexible neural mechanisms that enable multimodal control of breathing, emphasizing the role of pontomedullary circuits.
Nathan A. Baertsch +4 more
wiley +1 more source
Homeostatic synaptic plasticity of miniature excitatory postsynaptic currents in mouse cortical cultures requires neuronal <i>Rab3a</i>. [PDF]
ElifeKoesters AG, Rich MM, Engisch K.
europepmc +1 more source