Results 11 to 20 of about 143,385 (261)

AMPA Receptor Trafficking for Postsynaptic Potentiation [PDF]

open access: yesFrontiers in Cellular Neuroscience, 2018
Long-term potentiation (LTP) of excitatory synaptic strength, which has long been considered a synaptic correlate for learning and memory, requires a fast recruitment of additional α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors (AMPARs) to the postsynaptic sites.
Mikyoung Park, Mikyoung Park
openaire   +3 more sources

Brain Dystrophin in Duchenne Dystrophy

open access: yesPediatric Neurology Briefs, 1995
To define the potential pathogenic role of dystrophin deficiency in the cognitive impairment characteristic of Duchenne muscular dystrophy (DMD), the protein in brain cortical synapses of an 8-year-old patient examined at autopsy and an age-matched ...
J Gordon Millichap
doaj   +1 more source

Modeling Calcium Dynamics and Inhibition Based Synaptic Plasticity in Dendritic Spines

open access: yesMathematical Modelling and Analysis, 2014
Inhibitory synapses through GABAergic channels not only change spine's calcium dynamics but also modulate postsynaptic current mediated through glutamate receptors.
Muhammad Dur-e-Ahmad
doaj   +1 more source

Postsynaptic activity of inhibitory neurons evokes hemodynamic fMRI responses

open access: yesNeuroImage, 2021
Functional MRI responses are localized to the synaptic sites of evoked inhibitory neurons, but it is unknown whether, or by what mechanisms, these neurons initiate functional hyperemia.
Alexander John Poplawsky   +4 more
doaj   +1 more source

Acute application of Centella asiatica extract enhanced AMPAR-mediated postsynaptic currents in rat entorhinal cortex [PDF]

open access: yesJournal of Integrative Neuroscience, 2020
Centella asiatica is notable for its wide range of biological activities beneficial to human health, particularly its cognitive enhancement and neuroprotective effects.
Jia Hui Wong, Faruque Reza, Sangu Muthuraju, Huei Gau Chuang, Jingli Zhang, Mohd Harizal Senik, Siti Rafidah Yusof, Habsah Mohamad, Tengku Sifzizul Tengku Muhammad, Nor Hadiani Ismail, Jafri Malin Abdullah
doaj   +1 more source

Molecular model of postsynaptic potential. [PDF]

open access: yesProceedings of the National Academy of Sciences, 1975
A molecular model of the excitatory postsynaptic membrane is given in terms of two biochemical cycles intimately associated: an acetylcholine cycle and a calcium cycle. The acetylcholine controls the Na ionophores while calcium ions control the tk ionophore.
D M, Dubois, E, Schoffeniels
openaire   +2 more sources

Retrograde Synaptic Signaling Mediated by K+ Efflux through Postsynaptic NMDA Receptors

open access: yesCell Reports, 2013
Synaptic NMDA receptors (NMDARs) carry inward Ca2+ current responsible for postsynaptic signaling and plasticity in dendritic spines. Whether the concurrent K+ efflux through the same receptors into the synaptic cleft has a physiological role is not ...
Pei-Yu Shih   +7 more
doaj   +1 more source

Influence of Mpv17 on Hair-Cell Mitochondrial Homeostasis, Synapse Integrity, and Vulnerability to Damage in the Zebrafish Lateral Line

open access: yesFrontiers in Cellular Neuroscience, 2021
Noise exposure is particularly stressful to hair-cell mitochondria, which must produce enough energy to meet high metabolic demands as well as regulate local intracellular Ca2+ concentrations.
Melanie Holmgren   +2 more
doaj   +1 more source

Impairment Mechanisms and Intervention Approaches for Aged Human Neuromuscular Junctions

open access: yesFrontiers in Molecular Neuroscience, 2020
The neuromuscular junction (NMJ) is a chemical synapse formed between a presynaptic motor neuron and a postsynaptic muscle cell. NMJs in most vertebrate species share many essential features; however, some differences distinguish human NMJs from others ...
Yomna Badawi   +2 more
doaj   +1 more source

Occurrence of Ordered and Disordered Structural Elements in Postsynaptic Proteins Supports Optimization for Interaction Diversity

open access: yesEntropy, 2019
The human postsynaptic density is an elaborate network comprising thousands of proteins, playing a vital role in the molecular events of learning and the formation of memory.
Annamária Kiss-Tóth   +6 more
doaj   +1 more source

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