Results 21 to 30 of about 143,385 (261)

XE991 Reverses Enhanced Short-Term Plasticity in Rat Epileptic CA1

Brain Sciences
Background/Objectives: Recent evidence has suggested a transcriptional reduction in Kv7 potassium channels in the CA1 area of acquired experimental epilepsy, but presynaptic Kv7 channels might be spared.
Emma Schnell, Steffen Müller, Rüdiger Köhling, Timo Kirschstein   +3 more
doaj   +1 more source

GABAergic synaptic transmission regulates calcium influx during spike-timing dependent plasticity

Frontiers in Synaptic Neuroscience, 2010
Coincident pre- and postsynaptic activity of hippocampal neurons alters the strength of gamma-aminobutyric acid (GABAA)-mediated inhibition through a Ca2+-dependent regulation of cation-chloride cotransporters.
Trevor Balena, Brooke A Acton, Melanie A Woodin   +2 more
doaj   +1 more source

Anterograde Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction. [PDF]

PLoS ONE, 2014
Members of the TGF-β superfamily play numerous roles in nervous system development and function. In Drosophila, retrograde BMP signaling at the neuromuscular junction (NMJ) is required presynaptically for proper synapse growth and neurotransmitter ...
Myung-Jun Kim, Michael B O'Connor
doaj   +1 more source

Human synapses show a wide temporal window for spike-timing-dependent plasticity

Frontiers in Synaptic Neuroscience, 2010
Throughout our lifetime, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience.
Guilherme T Silva, Matthijs B Verhoog, Natalia B Goriounova, Alex Loebel, Johannes Hjorth, Johannes C Baayen, Christiaan P J De Kock, Huibert D Mansvelder   +7 more
doaj   +1 more source

The role of selected postsynaptic scaffolding proteins at glutamatergic synapses in autism-related animal models

Journal of Integrative Neuroscience, 2021
Pathological changes in synapse formation, plasticity, and development are caused by altered trafficking and assembly of postsynaptic scaffolding proteins at sites of glutamatergic and gamma-aminobutyric acid (GABA)ergic synapses, suggesting their ...
Veronika Meliskova, Tomas Havranek, Zuzana Bacova, Jan Bakos   +3 more
doaj   +1 more source

Postsynaptic GABA(B) Receptors Contribute to the Termination of Giant Depolarizing Potentials in CA3 Neonatal Rat Hippocampus

Frontiers in Cellular Neuroscience, 2017
During development, hippocampal CA3 network generates recurrent population bursts, so-called Giant Depolarizing Potentials (GDPs). GDPs are characterized by synchronous depolarization and firing of CA3 pyramidal cells followed by afterhyperpolarization ...
Ilgam Khalilov, Ilgam Khalilov, Marat Minlebaev, Marat Minlebaev, Marat Mukhtarov, Elvira Juzekaeva, Roustem Khazipov, Roustem Khazipov   +7 more
doaj   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Preparation of Pre- and Post-synaptic Density Fraction from Mouse Cortex

Bio-Protocol, 2013
The understanding of the organization of postsynaptic signaling systems at excitatory synapses has been aided by the identification of proteins in the postsynaptic density (PSD) fraction, a subcellular fraction enriched in structures with the morphology ...
Chengyong Shen, Yong-Jun Chen
doaj   +1 more source

The Association of Amyloid‐β and Tau With Synaptic Dysfunction in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the relative contributions of amyloid and tau to synaptic dysfunction in Alzheimer's disease (AD). Methods We included 109 cognitively unimpaired and impaired individuals from the Geneva Memory Center with available CSF synaptic biomarkers (neurogranin, SNAP‐25, GAP‐43). Participants were stratified according to amyloid (A)
Fausto Roveta, Augusto J. Mendes, Valentina Garibotto, Cecilia Boccalini, Aurelien Lathuiliere, Innocenzo Rainero, Elisa Rubino, Henrik Zetterberg, Nicholas J. Ashton, Federica Ribaldi, Giovanni B. Frisoni, for the Alzheimer's Disease Neuroimaging Initiative   +11 more
wiley   +1 more source

Molecular investigation of ergot alkaloid ergotamine's modulatory effects on glycine receptors expressed in Xenopus oocytes

Computational and Structural Biotechnology Journal
The relationship between oxidative stress and glycine receptors is complex, involving multiple mechanisms through which reactive oxygen species can modify glycine receptor function. Understanding these interactions is essential for developing therapeutic
Sanung Eom, Minsu Pyeon, Myungmi Moon, Jeongyeon Yun, Jaehui Yang, Jihwon Yun, Hye Duck Yeom, Mee-Hyun Lee, Gihyun Lee, Junho H. Lee   +9 more
doaj   +1 more source