Retrograde Synaptic Signaling Mediated by K+ Efflux through Postsynaptic NMDA Receptors
Synaptic NMDA receptors (NMDARs) carry inward Ca2+ current responsible for postsynaptic signaling and plasticity in dendritic spines. Whether the concurrent K+ efflux through the same receptors into the synaptic cleft has a physiological role is not ...
Pei-Yu Shih +7 more
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Impairment Mechanisms and Intervention Approaches for Aged Human Neuromuscular Junctions
The neuromuscular junction (NMJ) is a chemical synapse formed between a presynaptic motor neuron and a postsynaptic muscle cell. NMJs in most vertebrate species share many essential features; however, some differences distinguish human NMJs from others ...
Yomna Badawi +2 more
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Molecular model of postsynaptic potential. [PDF]
A molecular model of the excitatory postsynaptic membrane is given in terms of two biochemical cycles intimately associated: an acetylcholine cycle and a calcium cycle. The acetylcholine controls the Na ionophores while calcium ions control the tk ionophore.
D M, Dubois, E, Schoffeniels
openaire +2 more sources
Differential localization of glutamate receptor subunits at the drosophila neuromuscular junction [PDF]
The subunit composition of postsynaptic neurotransmitter receptors is a key determinant of synaptic physiology. Two glutamate receptor subunits, Drosophila glutamate receptor IIA (DGluRIIA) and DGluRIIB, are expressed at the Drosophila neuromuscular ...
Portman, Scott L. +5 more
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The human postsynaptic density is an elaborate network comprising thousands of proteins, playing a vital role in the molecular events of learning and the formation of memory.
Annamária Kiss-Tóth +6 more
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Synaptic transfer of dynamic motion information between identified neurons in the visual system of the blowfly [PDF]
Warzecha A-K, Kurtz R, Egelhaaf M. Synaptic transfer of dynamic motion information between identified neurons in the visual system of the blowfly. Neuroscience.
Egelhaaf, Martin ; https://orcid.org/ +2 more
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Antagonistic interactions between two Neuroligins coordinate pre- and postsynaptic assembly
As a result of developmental synapse formation, the presynaptic neurotransmitter release machinery becomes accurately matched with postsynaptic neurotransmitter receptors.
Escher, Marc J. F. +9 more
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GABAergic synaptic transmission regulates calcium influx during spike-timing dependent plasticity
Coincident pre- and postsynaptic activity of hippocampal neurons alters the strength of gamma-aminobutyric acid (GABAA)-mediated inhibition through a Ca2+-dependent regulation of cation-chloride cotransporters.
Trevor Balena +2 more
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Long-term potentiation through calcium-mediated N-Cadherin interaction is tightly controlled by the three-dimensional architecture of the synapse [PDF]
Poster presentation: Twenty Second Annual Computational Neuroscience Meeting: CNS*2013. Paris, France. 13-18 July 2013. The synaptic cleft is an extracellular domain that is capable of relaying a presynaptically received electrical signal by diffusive ...
Queisser, Sean Gillian +3 more
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Human synapses show a wide temporal window for spike-timing-dependent plasticity
Throughout our lifetime, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience.
Guilherme T Silva +7 more
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