Results 31 to 40 of about 8,644,509 (305)

Convulsant actions of 4-aminopyridine on the guinea-pig olfactory cortex slice [PDF]

, 1982
The effects of bath-applied 4-aminopyridine on neurones and extracellular potassium and calcium concentrations were recorded in slices of guinea-pig olfactory cortex. Neurones were orthodromically activated by stimulating the lateral olfactory tract.
Ten Bruggencate, Gerrit, Galvan, Martin, Grafe, Peter   +2 more
core   +1 more source

Rethinking the Role of Normalization and Residual Blocks for Spiking Neural Networks

Sensors, 2022
Biologically inspired spiking neural networks (SNNs) are widely used to realize ultralow-power energy consumption. However, deep SNNs are not easy to train due to the excessive firing of spiking neurons in the hidden layers.
Shin-ichi Ikegawa, Ryuji Saiin, Yoshihide Sawada, Naotake Natori   +3 more
doaj   +1 more source

Variability of postsynaptic responses depends non-linearly on the number of synaptic inputs [PDF]

, 2003
Kretzberg J, Sejnowski T, Warzecha A-K, Egelhaaf M. Variability of postsynaptic responses depends non-linearly on the number of synaptic inputs. Neurocomputing.
Egelhaaf, Martin ; https://orcid.org/, Sejnowski, Terrence, Warzecha, Anne-Kathrin, Kretzberg, Jutta   +3 more
core   +1 more source

Preparation of Pre- and Post-synaptic Density Fraction from Mouse Cortex

Bio-Protocol, 2013
The understanding of the organization of postsynaptic signaling systems at excitatory synapses has been aided by the identification of proteins in the postsynaptic density (PSD) fraction, a subcellular fraction enriched in structures with the morphology ...
Chengyong Shen, Yong-Jun Chen
doaj   +1 more source

Targeting the post-synaptic proteome has therapeutic potential for psychosis in Alzheimer Disease

Communications Biology, 2023
Individuals with Alzheimer Disease who develop psychotic symptoms (AD + P) experience more rapid cognitive decline and have reduced indices of synaptic integrity relative to those without psychosis (AD-P).
J. M. Krivinko, M. R. DeChellis-Marks, L. Zeng, P. Fan, O. L. Lopez, Y. Ding, L. Wang, J. Kofler, M. L. MacDonald, R. A. Sweet   +9 more
doaj   +1 more source

Neuromodulation of Chemical Synaptic Transmission Driven by THz Photons

Research, 2022
Postsynaptic currents of chemical synapse are modulated by multitudinous neurotransmitters, such as acetylcholine, dopamine, glutamate, and γ-aminobutyric acid, many of which have been used in the treatment of neurological diseases.
Xiaoxuan Tan, Yuan Zhong, Ruijie Li, Chao Chang   +3 more
doaj   +1 more source

Molecular investigation of ergot alkaloid ergotamine's modulatory effects on glycine receptors expressed in Xenopus oocytes

Computational and Structural Biotechnology Journal
The relationship between oxidative stress and glycine receptors is complex, involving multiple mechanisms through which reactive oxygen species can modify glycine receptor function. Understanding these interactions is essential for developing therapeutic
Sanung Eom, Minsu Pyeon, Myungmi Moon, Jeongyeon Yun, Jaehui Yang, Jihwon Yun, Hye Duck Yeom, Mee-Hyun Lee, Gihyun Lee, Junho H. Lee   +9 more
doaj   +1 more source

Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex

eLife, 2020
In the cerebellar cortex, molecular layer interneurons use chemical and electrical synapses to form subnetworks that fine-tune the spiking output of the cerebellum.
Andreas Hoehne, Maureen H McFadden, David A DiGregorio   +2 more
doaj   +1 more source

Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins

Cell Reports, 2022
Summary: Neurexins (NRXNs) are key presynaptic cell adhesion molecules that regulate synapse formation and function via trans-synaptic interaction with postsynaptic ligands.
Takeshi Uemura, Emi Suzuki-Kouyama, Shiori Kawase, Taiga Kurihara, Misato Yasumura, Tomoyuki Yoshida, Shuya Fukai, Maya Yamazaki, Peng Fei, Manabu Abe, Masahiko Watanabe, Kenji Sakimura, Masayoshi Mishina, Katsuhiko Tabuchi   +13 more
doaj   +1 more source

Postsynaptic recordings at afferent dendrites contacting cochlear inner hair cells: Monitoring multivesicular release at a ribbon synapse [PDF]

, 2011
The afferent synapse between the inner hair cell (IHC) and the auditory nerve fiber provides an electrophysiologically accessible site for recording the postsynaptic activity of a single ribbon synapse.
Eunyoung Yi, Glowatzki, Elisabeth, Yi, Eunyoung, Elisabeth Glowatzki, Grant, Lisa, Lisa Grant, Juan D. Goutman, Goutman, Juan Diego   +7 more
core   +1 more source