Results 221 to 230 of about 134,202 (290)

Serotonergic Signaling Rewired: A Lipid Raft-Controlled Model of Synaptic Transmission Grounded in the Fundamental Parameters of Biological Systems. [PDF]

Life (Basel)
Fantini J, Lefebvre M, Yahi N, Chahinian H.   +3 more
europepmc   +1 more source

Underlying Mechanisms of the Treatment Efficacy of (R, S)‐Ketamine for Post‐Traumatic Stress Disorder and Depression: A Review

Medicine Advances, EarlyView.
Research shows that (R, S)‐ketamine and its stereoisomers effectively reduce symptoms of post‐traumatic stress disorder (PTSD) and treatment‐resistant depression, with (R)‐ketamine offering similar benefits with fewer side effects. Evidence highlights specific neural circuits and regions, including the dentate gyrus, prefrontal cortex, vCA3, dorsal ...
Thomas Edward Cutting, Richard Evans Hartman   +1 more
wiley   +1 more source

Dlgap2 deficiency disrupts synaptic homeostasis by promoting ubiquitin-mediated Itsn1 degradation in a valproic acid-induced autism-like model. [PDF]

Sci Rep
Guo X, Zhang L, Zhuang K.
europepmc   +1 more source

Role of NMDA and Non-NMDA Receptors in Excitatory Postsynaptic Potentials in Rat Suprachiasmatic Nucleus Neurons.

, 1992
Shingo Shoji, Hiroshi Hasuo, Takashi Akasu, Masaru Ishimatsu   +3 more
openalex   +2 more sources

Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders

Neuroprotection, EarlyView.
The graphical abstract encapsulates the dual neuroprotective mechanisms of statins in neurodegenerative diseases, highlighting both cholesterol‐dependent and cholesterol‐independent pathways. By inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, statins reduce cholesterol synthesis, leading to altered lipid raft structures that ...
Jun Han Kuan, Roshan S. Raghavan, Dawn Li Wei Koh, Wing Yeng Tan, Igor Iezhitsa, Renu Agarwal   +5 more
wiley   +1 more source

Non-Synaptic Mechanism of Ocular Dominance Plasticity. [PDF]

ASN Neuro
Foote MK, Huffman WC, Santos EN, Lee PR, Jarnik M, Li W, Bonifacino JS, Fields RD.   +7 more
europepmc   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Research progress in <i>SYNGAP1</i>-related neurodevelopmental disorders: from pathogenesis to therapeutic strategies. [PDF]

Front Neurol
Zhang J, Xue G, Wang X, Rao X, Chen J, Fan L, Liu L, Gan J.   +7 more
europepmc   +1 more source

Bioinformatics‐Driven Design and Evaluation of Recombinant Multi‐Epitope Immunogens Derived From Snake Venom Toxins as Potential Antivenom Candidates

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley   +1 more source

When the saline hits your brain: effects of standard irrigation solutions on neural function. [PDF]

J Neurosurg
Carlson AP, Bennett MC, Provencio JJ, Shuttleworth CW.   +3 more
europepmc   +1 more source