Results 21 to 30 of about 10,704,455 (290)

Impairment Mechanisms and Intervention Approaches for Aged Human Neuromuscular Junctions

Frontiers in Molecular Neuroscience, 2020
The neuromuscular junction (NMJ) is a chemical synapse formed between a presynaptic motor neuron and a postsynaptic muscle cell. NMJs in most vertebrate species share many essential features; however, some differences distinguish human NMJs from others ...
Yomna Badawi, Hiroshi Nishimune, Hiroshi Nishimune   +2 more
doaj   +1 more source

Occurrence of Ordered and Disordered Structural Elements in Postsynaptic Proteins Supports Optimization for Interaction Diversity

Entropy, 2019
The human postsynaptic density is an elaborate network comprising thousands of proteins, playing a vital role in the molecular events of learning and the formation of memory.
Annamária Kiss-Tóth, Laszlo Dobson, Bálint Péterfia, Annamária F. Ángyán, Balázs Ligeti, Gergely Lukács, Zoltán Gáspári   +6 more
doaj   +1 more source

Differential Effects of D-Cycloserine and ACBC at NMDA Receptors in the Rat Entorhinal Cortex Are Related to Efficacy at the Co-Agonist Binding Site. [PDF]

PLoS ONE, 2015
Partial agonists at the NMDA receptor co-agonist binding site may have potential therapeutic efficacy in a number of cognitive and neurological conditions. The entorhinal cortex is a key brain area in spatial memory and cognitive processing.
Alex M Lench, Emma Robson, Roland S G Jones   +2 more
doaj   +1 more source

GABAergic synaptic transmission regulates calcium influx during spike-timing dependent plasticity

Frontiers in Synaptic Neuroscience, 2010
Coincident pre- and postsynaptic activity of hippocampal neurons alters the strength of gamma-aminobutyric acid (GABAA)-mediated inhibition through a Ca2+-dependent regulation of cation-chloride cotransporters.
Trevor Balena, Brooke A Acton, Melanie A Woodin   +2 more
doaj   +1 more source

Rethinking the Role of Normalization and Residual Blocks for Spiking Neural Networks

Sensors, 2022
Biologically inspired spiking neural networks (SNNs) are widely used to realize ultralow-power energy consumption. However, deep SNNs are not easy to train due to the excessive firing of spiking neurons in the hidden layers.
Shin-ichi Ikegawa, Ryuji Saiin, Yoshihide Sawada, Naotake Natori   +3 more
doaj   +1 more source

Human synapses show a wide temporal window for spike-timing-dependent plasticity

Frontiers in Synaptic Neuroscience, 2010
Throughout our lifetime, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience.
Guilherme T Silva, Matthijs B Verhoog, Natalia B Goriounova, Alex Loebel, Johannes Hjorth, Johannes C Baayen, Christiaan P J De Kock, Huibert D Mansvelder   +7 more
doaj   +1 more source

Neuromodulation of Chemical Synaptic Transmission Driven by THz Photons

Research, 2022
Postsynaptic currents of chemical synapse are modulated by multitudinous neurotransmitters, such as acetylcholine, dopamine, glutamate, and γ-aminobutyric acid, many of which have been used in the treatment of neurological diseases.
Xiaoxuan Tan, Yuan Zhong, Ruijie Li, Chao Chang   +3 more
doaj   +1 more source

Preparation of Pre- and Post-synaptic Density Fraction from Mouse Cortex

Bio-Protocol, 2013
The understanding of the organization of postsynaptic signaling systems at excitatory synapses has been aided by the identification of proteins in the postsynaptic density (PSD) fraction, a subcellular fraction enriched in structures with the morphology ...
Chengyong Shen, Yong-Jun Chen
doaj   +1 more source

Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins

Cell Reports, 2022
Summary: Neurexins (NRXNs) are key presynaptic cell adhesion molecules that regulate synapse formation and function via trans-synaptic interaction with postsynaptic ligands.
Takeshi Uemura, Emi Suzuki-Kouyama, Shiori Kawase, Taiga Kurihara, Misato Yasumura, Tomoyuki Yoshida, Shuya Fukai, Maya Yamazaki, Peng Fei, Manabu Abe, Masahiko Watanabe, Kenji Sakimura, Masayoshi Mishina, Katsuhiko Tabuchi   +13 more
doaj   +1 more source

Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex

eLife, 2020
In the cerebellar cortex, molecular layer interneurons use chemical and electrical synapses to form subnetworks that fine-tune the spiking output of the cerebellum.
Andreas Hoehne, Maureen H McFadden, David A DiGregorio   +2 more
doaj   +1 more source