Functional maps of neocortical local circuitry
Frontiers in Neuroscience, 2007 This review aims to summarize data obtained with different techniques to provide a functional map of the local circuit connections made by neocortical neurones, a reference for those interested in cortical circuitry and the numerical information required
Alex M Thomson, Christophe Lamy
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Modeling Calcium Dynamics and Inhibition Based Synaptic Plasticity in Dendritic Spines
Mathematical Modelling and Analysis, 2014 Inhibitory synapses through GABAergic channels not only change spine's calcium dynamics but also modulate postsynaptic current mediated through glutamate receptors.
Muhammad Dur-e-Ahmad
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Brain Dystrophin in Duchenne Dystrophy
Pediatric Neurology Briefs, 1995 To define the potential pathogenic role of dystrophin deficiency in the cognitive impairment characteristic of Duchenne muscular dystrophy (DMD), the protein in brain cortical synapses of an 8-year-old patient examined at autopsy and an age-matched ...
J Gordon Millichap
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Retrograde Synaptic Signaling Mediated by K+ Efflux through Postsynaptic NMDA Receptors
Cell Reports, 2013 Synaptic NMDA receptors (NMDARs) carry inward Ca2+ current responsible for postsynaptic signaling and plasticity in dendritic spines. Whether the concurrent K+ efflux through the same receptors into the synaptic cleft has a physiological role is not ...
Pei-Yu Shih +7 more
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Impairment Mechanisms and Intervention Approaches for Aged Human Neuromuscular Junctions
Frontiers in Molecular Neuroscience, 2020 The neuromuscular junction (NMJ) is a chemical synapse formed between a presynaptic motor neuron and a postsynaptic muscle cell. NMJs in most vertebrate species share many essential features; however, some differences distinguish human NMJs from others ...
Yomna Badawi +2 more
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Entropy, 2019 The human postsynaptic density is an elaborate network comprising thousands of proteins, playing a vital role in the molecular events of learning and the formation of memory.
Annamária Kiss-Tóth +6 more
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Differential Effects of D-Cycloserine and ACBC at NMDA Receptors in the Rat Entorhinal Cortex Are Related to Efficacy at the Co-Agonist Binding Site. [PDF]
PLoS ONE, 2015 Partial agonists at the NMDA receptor co-agonist binding site may have potential therapeutic efficacy in a number of cognitive and neurological conditions. The entorhinal cortex is a key brain area in spatial memory and cognitive processing.
Alex M Lench +2 more
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GABAergic synaptic transmission regulates calcium influx during spike-timing dependent plasticity
Frontiers in Synaptic Neuroscience, 2010 Coincident pre- and postsynaptic activity of hippocampal neurons alters the strength of gamma-aminobutyric acid (GABAA)-mediated inhibition through a Ca2+-dependent regulation of cation-chloride cotransporters.
Trevor Balena +2 more
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Human synapses show a wide temporal window for spike-timing-dependent plasticity
Frontiers in Synaptic Neuroscience, 2010 Throughout our lifetime, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience.
Guilherme T Silva +7 more
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Neuromodulation of Chemical Synaptic Transmission Driven by THz Photons
Research, 2022 Postsynaptic currents of chemical synapse are modulated by multitudinous neurotransmitters, such as acetylcholine, dopamine, glutamate, and γ-aminobutyric acid, many of which have been used in the treatment of neurological diseases.
Xiaoxuan Tan +3 more
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